Designing Low Carb diets for Heart Health | Dr. Ethan Weiss Nutrition Made Simple! 2022-11-07 | Low Carb doesn't have to equal high cholesterol and heart disease risk. Low Carb cardiologist Dr. Ethan Weiss shares his heart-healthy Low Carb diet.Dr. Ethan Weiss, cardiologist and Prof. of Medicine at UCSF and low carb dieter for ~5ylast week’s video on cholesterol and saturated fat on low carb + low carb diet by a professional in heart health ApoB. fats like cholesterol and triglycerides travel in our blood in lipoproteins lipoproteins can enter artery wall and cause plaque. ApoB is a blood test that gives us a count of the number of those problem lipoproteinsis high cholesterol a problem on low carb? Dr. Weiss goes by ApoB given its implication in cardiovascular diseaseis high cholesterol ok as long as HDL-c is also high and triglycerides are low? what’s your ApoB? HDL-c is a good marker of risk but probably not a mediator, not a cause triglycerides appear to be mainly a reflection of the lipoproteins that carry them, ApoBnew trial: lowering triglycerides without changing ApoB didnt affect cardiovascular risk, targeting triglycerides per se may not be very useful for heart disease, the goal is to get the lipoproteins, the ApoB, in the healthy rangesaturated fat and low carb: saturated fat raises ApoB, so Dr. Weiss looks at ApoBcalcium score: CAC=0 more meaningful in an older person. a young person with a high calcium score is a concerncalcium is not a good test of whether exposure to high cholesterol for a few years raises risk. statins raise calcium score while lowering cardiovascular risk. Statins have a plaque-stabilizing effect, the calcification may be related to thisare LDL particles harmless if not oxidized? Dr. Weiss considers measuring oxidized particles in circulation and trying to change that value a distraction, best evidence hasn’t shown an effect on cardiovascular risk. apoB in the healthy range is likely to get oxidized anywaypractical ideas on how to eat low carb while minding heart health. low carb doesn't have to mean high cholesterol, we’re not forced to choose between diabetes & high cholesterolSubscribe for more free nutrition and health tips: bit.ly/2toMJ9uConnect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1-ncbi.nlm.nih.gov/pmc/articles/PMC41035142-jamanetwork.com/journals/jama/article-abstract/27227703-nejm.org/doi/full/10.1056/NEJMoa22106454-jacc.org/doi/abs/10.1016/j.jacc.2015.01.036Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Intro0:30 ApoB1:03 Recap: Cholesterol and saturated fat on low carb diets4:00 Recap: the calcium score (CAC) and statins5:30 Recap: oxidized lipoproteins6:34 Dr. Weiss´ diet: Low carb for heart health12:11 Fat types: oil & butter14:10 Salt15:18 Risk factors & importance of not settling
COVID, RFK Jr and the Crisis of Scientific Trust Nutrition Made Simple! 2023-07-03 | Many have lost trust in science and scientific institutions and have turned to figures seen as "anti-establishment" like Joe Rogan and RFK Jr. What does this reveal about our society and how do we move forward?Connect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaDisclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 A Crisis of Scientific Trust0:51 A Rift2:00 Anti-establishment figures4:48 A Clash5:28 Battles vs Science7:46 My contribution10:00 Access is power
Cholesterol & Risk of Death | New Evidence Emerges Nutrition Made Simple! 2023-06-26 | Are low cholesterol levels dangerous? Do they raise risk of death? A look at the evidence and its significance.Connect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1.nature.com/articles/s41598-018-38461-y2. bmj.com/content/371/bmj.m42663. sciencedirect.com/science/article/pii/S00029165230502444.cardiab.biomedcentral.com/articles/10.1186/s12933-015-0179-2/figures/4nature.com/articles/s41591-020-0785-85. sciencedirect.com/science/article/pii/S10501738193006846. jacc.org/doi/full/10.1016/j.jacc.2008.06.0367. journals.lww.com/co-lipidology/Abstract/2018/08000/Acquired_low_cholesterol__diagnosis_and_relevance.8.aspx8. cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011737.pub3/full9. ncbi.nlm.nih.gov/pmc/articles/PMC343797210. academic.oup.com/ije/article/44/2/604/75317111. sciencedirect.com/science/article/abs/pii/S146238890500108012. aspenjournals.onlinelibrary.wiley.com/doi/abs/10.1177/01154265060210016813. onlinelibrary.wiley.com/doi/full/10.1111/jdi.1269814. sciencedirect.com/science/article/abs/pii/S147020450570170415. sciencedirect.com/science/article/abs/pii/S1525861017306746Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Low cholesterol raises risk of death?1:12 The U curve2:20 BMI3:09 Blood pressure3:43 HbA1c4:23 Disease lowers cholesterol6:49 U curves are common7:52 A thought experiment
Are the Dietary Guidelines making us all fat and sick?! Nutrition Made Simple! 2023-06-19 | We have an epidemic of obesity and type 2 diabetes on our hands. Are the Dietary Guidelines responsible? Is it time to try something else? What needs to change to address this urgent problem?Subscribe for more free nutrition and health tips: bit.ly/2toMJ9uConnect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1-niddk.nih.gov/health-information/health-statistics/overweight-obesity2-cdc.gov/diabetes/statistics/slides/long_term_trends.pdf3-ncbi.nlm.nih.gov/pmc/articles/PMC52201634-cdc.gov/mmwr/preview/mmwrhtml/mm5837a9.htm death 5-prb.org/resources/u-s-trends-in-heart-disease-cancer-and-stroke6-dietaryguidelines.gov/sites/default/files/2021-03/Dietary_Guidelines_for_Americans-2020-2025.pdf7-ncbi.nlm.nih.gov/pmc/articles/PMC58551728-nature.com/articles/16019899-sciencedirect.com/science/article/pii/S002231662200909910-sciencedirect.com/science/article/pii/S221226722031157611-sciencedirect.com/science/article/abs/pii/S221226721500387112-mdpi.com/2072-6643/14/8/154513-ahajournals.org/doi/full/10.1161/HYPERTENSIONAHA.109.13123514-sciencedirect.com/science/article/pii/S000291652202934315-liebertpub.com/doi/abs/10.1089/met.2014.011216-sciencedirect.com/science/article/pii/S093947532100453117-ncbi.nlm.nih.gov/pmc/articles/PMC885512118-academic.oup.com/ajcn/article/101/5/922/4577558jacc.org/doi/full/10.1016/j.jacc.2016.10.08919-healthland.time.com/2011/06/02/the-usda-ditches-the-food-pyramid-and-offers-a-plateDisclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 An epidemic of obesity1:55 Is everyone getting sicker?3:00 Do people follow the guidelines?4:58 Are the guidelines health-promoting?8:55 Time to ditch the guidelines?10:10 What the guidelines get wrong10:58 Does one size fit all?
How he lost 58lbs eating *ONLY* McDonald´s | The power of Anecdotes Nutrition Made Simple! 2023-06-12 | Is it possible to lose 58lbs by eating ONLY McDonald´s food? A man proved it possible and generated a media storm. What does this tell us about food & health? Are anecdotes reliable? Are they useful? Should we simply ignore them all?Connect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1-ahajournals.org/doi/10.1161/HYPERTENSIONAHA.114.039462-jamanetwork.com/journals/jamainternalmedicine/article-abstract/5828483-pubmed.ncbi.nlm.nih.gov/12007264-acpjournals.org/doi/epdf/10.7326/0003-4819-31-5-8215-sciencedirect.com/science/article/abs/pii/S0022073614001654Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Losing weight at MdDonald´s0:56 The problem with anecdotes3:03 The Rice Diet4:50 Our emotions blind us6:25 Usefulness & danger of anecdotes
Dont be fooled by RATIOS like Triglycerides:HDL-C Nutrition Made Simple! 2023-06-05 | Are ratios like triglycerides:HDL-C or total cholesterol:HDL-C a reliable measure of our risk of heart disease? We cover the good, the bad and the ugly about cholesterol ratios and common misunderstandings.Connect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1-frontiersin.org/articles/10.3389/fcvm.2021.718604/full2-europepmc.org/article/med/103222523-ahajournals.org/doi/full/10.1161/01.ATV.16.12.1509 TG & bmi4-pubmed.ncbi.nlm.nih.gov/21291667 hdl & multi5-nejm.org/doi/full/10.1056/NEJMoa2210645 tg lowering n.s.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.119.041998 tg RCTs6-jamanetwork.com/journals/jama/article-abstract/2722770 ference mr7-ncbi.nlm.nih.gov/pmc/articles/PMC4103514 hdl meta8-journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003062 Korpela mr9-pubmed.ncbi.nlm.nih.gov/33870931 update on apoB, goes over MR10-jamanetwork.com/journals/jama/fullarticle/2749533 bp mr11-academic.oup.com/eurheartj/article/41/35/3304/5821049?login=false tobacco mr12-sciencedirect.com/science/article/abs/pii/S0002870305008707Past videos covering ApoB and correlation vs causation:youtu.be/ntD4eN-9t-Qyoutu.be/-B8ybQ-L264Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Cohlesterol ratios correlate with risk1:10 Correlation vs causation3:49 Hearing from the EAS President4:31 Population vs individual8:17 Take-home message8:28 ApoA-I
Scientist shares TOP10 Nutrition Sources Online Nutrition Made Simple! 2023-05-29 | My TOP10 online sources on nutrition. Youtube channels, podcasts, Twitter accounts, blogs etc. These resources will revolutionize your knowledge of nutrition and health.Subscribe for more free nutrition and health tips: bit.ly/2toMJ9uConnect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaLinks:1-redpenreviews.org2-peterattiamd.com/podcast3-drguess.substack.comtwitter.com/Dr__Guess4-twitter.com/Drlipid5-youtube.com/@biolayne16-youtube.com/@DrBradStanfield7-twitter.com/KevinH_PhD8-twitter.com/deirdre_tobias9-theproof.com/podcast10-sigmanutrition.comDisclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho
Overcoming IBS (Irritable Bowel) & conquering Gut Health | Dr. William Chey, MD Nutrition Made Simple! 2023-05-22 | A complete look at causes, diagnosis and treatment of IBS by one of the leading world experts. Gastroenterologist Dr. William Chey takes us through what causes Irritable Bowel (IBS), how to distinguish it from other similar diseases and how to treat it. The role of diet, medication, behavioral therapy, probiotics and acupuncture in IBS.Follow Dr. Chey on Twitter: @umfoodocConnect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1-jamanetwork.com/journals/jama/article-abstract/21740342-europepmc.org/article/med/344630823-sciencedirect.com/science/article/abs/pii/S00165085060051294-sciencedirect.com/science/article/abs/pii/S15216918070003395-ncbi.nlm.nih.gov/pmc/articles/PMC81326736-sciencedirect.com/science/article/pii/S154235652030433X7-onlinelibrary.wiley.com/doi/full/10.1111/jgh.137018-onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2982.2005.00627.x9-ncbi.nlm.nih.gov/pmc/articles/PMC538311010-ncbi.nlm.nih.gov/pmc/articles/PMC538311011-sciencedirect.com/science/article/pii/S000292700204270312-gut.bmj.com/content/early/2023/03/14/gutjnl-2023-329714.abstract13-sciencedirect.com/science/article/abs/pii/S001650850900361814-ncbi.nlm.nih.gov/pmc/articles/PMC817119615-onlinelibrary.wiley.com/doi/abs/10.1111/apt.1658216-pubmed.ncbi.nlm.nih.gov/3318918117-link.springer.com/article/10.1007/s00406-014-0502-z18-ncbi.nlm.nih.gov/pmc/articles/PMC4632879gastrojournal.org/article/S0016-5085(11)00087-4/fulltext19-ncbi.nlm.nih.gov/pmc/articles/PMC436720920-bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-020-02654-5?tandfonline.com/doi/full/10.2147/NDT.S24355121-liebertpub.com/doi/abs/10.1089/acm.2016.0023link.springer.com/article/10.1007/s40139-018-0160-322-ncbi.nlm.nih.gov/books/NBK8476323-pubmed.ncbi.nlm.nih.gov/2859244224-sciencedirect.com/science/article/abs/pii/S246812532030215625-acpjournals.org/doi/abs/10.7326/m15-311826-sciencedirect.com/science/article/pii/S002561962030151827-hindawi.com/journals/prm/2019/287150528-worldscientific.com/doi/abs/10.1142/S0192415X9600024429-pubmed.ncbi.nlm.nih.gov/3331559130-pubmed.ncbi.nlm.nih.gov/2573241931-guysandstthomas.nhs.uk/health-information/sehcat-study32-pubmed.ncbi.nlm.nih.gov/3115233233-journals.sagepub.com/doi/pdf/10.1177/205064061982641934-onlinelibrary.wiley.com/doi/full/10.1111/apt.1357335-youtube.com/watch?v=uEM2iDT-VAk36-pubmed.ncbi.nlm.nih.gov/2364495537-pubmed.ncbi.nlm.nih.gov/3242692238-sciencedirect.com/science/article/abs/pii/S159086582100247439-monashfodmap.com/ibs-central/i-have-ibs/starting-the-low-fodmap-dietmonashfodmap.com/3_step_fodmap_diet40-ncbi.nlm.nih.gov/pmc/articles/PMC9169754/#R5841-sciencedirect.com/science/article/pii/S221287781600038742-ncbi.nlm.nih.gov/pmc/articles/PMC484887043-onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2036.1995.tb00433.x44-spandidos-publications.com/10.3892/ijmm.2017.307245-sciencedirect.com/science/article/pii/S001650852200391246-pubmed.ncbi.nlm.nih.gov/1686356447-sciencedirect.com/science/article/abs/pii/S001650850402155948-onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2982.2005.00695.x49-sciencedirect.com/science/article/abs/pii/S138917231100534250-sciencedirect.com/science/article/abs/pii/S0016508517355579Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Highlights0:12 Intro1:24 What is IBS?10:59 What causes IBS?24:50 Multipronged therapy32:27 Diagnostic tests41:00 Wheat intolerance & SIBO48:03 Histamine intolerance51:06 Low FODMAP & other diets1:04:10 Fiber1:08:07 Probiotics1:13:35 Summary & Takeaways
New Diet Trial Cuts Diabetes in Half! Nutrition Made Simple! 2023-05-15 | Can we reverse diabetes with diet only? A brand new trial reports impressive results using a dietary tweak. Approximately half of diabetic participants achieved remission and got off their diabetes meds. Connect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1-academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgac661/68880052-https://apps.who.int/iris/bitstream/handle/10665/206936/0957708211_eng.pdf3-pubmed.ncbi.nlm.nih.gov/344598984-pubmed.ncbi.nlm.nih.gov/292216455-pubmed.ncbi.nlm.nih.gov/308521326-frontiersin.org/articles/10.3389/fendo.2019.00348/fullDisclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 New diabetes trial2:08 The results3:41 Follow-up6:33 Results at 1 year8:15 2 Takeaways10:06 Context: DiRECT and Virta
Is Inflammation the real cause of Heart Disease? | Prof. Kausik Ray Nutrition Made Simple! 2023-05-08 | What role does inflammation play in heart disease, plaque growth and risk of heart attacks? If we keep inflammation in check, is that enough to keep our heart disease risk down? Is inflammation the "real cause" of heart disease or one factor among many?Subscribe for more free nutrition and health tips: bit.ly/2toMJ9uFollow Prof. Ray on Twitter:@ProfKausikRayConnect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1-academic.oup.com/eurheartj/article/41/24/2313/57352212-atherosclerosis-journal.com/article/S0021-9150(23)00154-5/fulltext3-jrheum.org/content/32/7/1219.short4-sciencedirect.com/science/article/pii/S01406736106217455-nejm.org/doi/full/10.1056/NEJMoa17079146-jacc.org/doi/epdf/10.1016/j.jacc.2019.08.0127-sciencedirect.com/science/article/abs/pii/S00029149030063378-ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.118.034032#sciencedirect.com/science/article/pii/S266666772030091X9-thelancet.com/journals/lancet/article/PIIS0140-6736(23)00215-5/fulltext10-nejm.org/doi/full/10.1056/NEJMoa042378Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Intro1:10 Is inflammation necessary for Heart Disease?2:45 Can we stop inflammation?4:00 Do statins work by reducing inflammation?5:19 Summary and Takeaways
You NEED 8 glasses of water a day!: MYTH or FACT?! Nutrition Made Simple! 2023-05-01 | We've all heard the recommendation to drink 8 glasses of water a day. But is it based on sound science?Do we really need or 8 glasses of water a day? We’ve all heard this advice but I’ve never seen any evidence so I decided to dig around.I found a lot of interesting research on hydration but nothing pointing to 8 glasses specifically.There’s mixed evidence on heart disease and cancer and nothing about the 8 glass range.The evidence on skin health suggests that for someone who drinks very little and is dehydrated, increasing water intake may improve some skin properties.Several experts recommend just trusting your thirst, drinking when ur thirsty and not obsessing over drinking more water or a specific amount. Special situations where it may make sense to try to drink more:If you exercise you lose more water so you need to increase intake; if you live somewhere warm; If out working or exercising in the sun you’ll lose water very fast so it’s a good idea to hydrate in advance even before thirst hits; pregnant or breast-feeding; in children and older people sometimes thirst alone isnt effective. E.g. the thirst reflex goes down with age; If you have kidney stones or a family history, you definitely want to drink more water; extra hydration can help prevent UTIs and it can help with chronic constipation as wellWhat about weight loss? Can drinking more water help us lose weight? Our energy expenditure goes up right after we drink water. Drinking water before meals can help us eat less and lose weight.Connect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1-academic.oup.com/aje/article/155/9/827/582242-pubmed.ncbi.nlm.nih.gov/204568123-www.nejm.org/doi/full/10.1056/NEJM1999050634018034-www.nature.com/articles/16019035-journals.physiology.org/doi/full/10.1152/ajpregu.00365.20026-pubmed.ncbi.nlm.nih.gov/168276957-www.tandfonline.com/doi/pdf/10.2147/CCID.S868228-www.mcgill.ca/oss/article/health-nutrition/water-myth9-journals.physiology.org/doi/epdf/10.1152/ajpregu.00365.200210-www.tandfonline.com/doi/abs/10.1080/07315724.2007.1071966611-www.ncbi.nlm.nih.gov/books/NBK234935/?report=reader#!po=4.5454512-www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD009647.pub2/full13-academic.oup.com/biomedgerontology/article/55/7/M361/2948068 14-pubmed.ncbi.nlm.nih.gov/1932125315-www.sciencedirect.com/science/article/pii/S215717161532146816-www.sciencedirect.com/science/article/abs/pii/S0270929508000508onlinelibrary.wiley.com/doi/full/10.1111/joim.1265417-journals.sagepub.com/doi/pdf/10.1258/00045630778164603018-www.science.org/doi/10.1126/science.abm866819-www.ncbi.nlm.nih.gov/pmc/articles/PMC658432320-europepmc.org/article/med/968412321-academic.oup.com/jcem/article/92/8/3334/259868122-www.ncbi.nlm.nih.gov/pmc/articles/PMC6209729 23-onlinelibrary.wiley.com/doi/pdf/10.1038/oby.2009.235www.ncbi.nlm.nih.gov/pmc/articles/PMC3809630www.ncbi.nlm.nih.gov/pmc/articles/PMC4121911 24-academic.oup.com/jn/article/144/11/1742/459006725-publications.aap.org/pediatrics/article-abstract/123/4/e661/71356/Promotion-and-Provision-of-Drinking-Water-in26-pubmed.ncbi.nlm.nih.gov/1612887427-www.ncbi.nlm.nih.gov/books/NBK23493528-www.mdpi.com/1648-9144/55/9/53729-www2.hcmuaf.edu.vn/data/lhquang/file/Coffee/Caffeine%20ingestion.pdf30-journals.plos.org/plosone/article?id=10.1371/journal.pone.008415431-www.mdpi.com/2072-6643/9/7/66032-www.sciencedirect.com/science/article/abs/pii/003193848490154933-journals.physiology.org/doi/epdf/10.1152/ajpregu.00365.200234-pubmed.ncbi.nlm.nih.gov/3065683935-https://dspace.gipe.ac.in/xmlui/bitstream/handle/10973/36074/GIPE-031998.pdf36-www.ncbi.nlm.nih.gov/pmc/articles/PMC7692653Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 8 glasses a day0:27 Water & Heart Disease 1:02 Water & Cancer 2:03 Water & Skin5:20 Special situations8:36 Water & Weight Loss12:08 Water & Migraine12:47 Replacement13:11 Risks of drinking more water14:02 Water in food14:25 Coffe, alcohol & (de)hydration15:58 Does thirst mean dehydration?16:44 Urine color & dehydration17:58 A nephrologist speaks19:43 Origins of "8 glasses"20:36 Takeaways
Intermittent Fasting for Fatty Liver | New clinical trial Nutrition Made Simple! 2023-04-24 | New trial looks at Intermittent Fasting for fatty liver disease. Does fasting help reduce fatty liver more than just cutting calories? A look at the effect of Time Restricted Eating in fatty liver disease.Connect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1jamanetwork.com/journals/jamanetworkopen/fullarticle/28025532-www.nature.com/articles/s41467-022-28662-53-cell.com/current-biology/fulltext/S0960-9822(20)31669-9Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 What is fatty liver?0:25 New trial2:17 Results4:54 Caloric intake6:14 Main takeaway7:11 Time of eating and metabolism8:11 Should we all fast?8:36 Main dietary factors for health
How to *GAIN* Weight in a Healthy Way! | Dr. Spencer Nadolsky Nutrition Made Simple! 2023-04-17 | Everyone talks about weight LOSS but what about people who want to GAIN some weight in a healthy way? Without fad diets or jeopardizing their health? We cover 6 tips for gaining weight in a healthy way, from food to exercise and FAQs.Connect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1-link.springer.com/article/10.1007/s00125-020-05104-92-faseb.onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fj.13-2302273-tandfonline.com/doi/full/10.1186/s12970-018-0215-14-link.springer.com/article/10.1007/s11932-002-0017-75-faseb.onlinelibrary.wiley.com/doi/abs/10.1096/fj.202200398RRlink.springer.com/article/10.1007/s40279-016-0496-y6-onlinelibrary.wiley.com/doi/10.1002/jcsm.12922Resistance training program for beginners: muscleandstrength.com/workouts/3day-beginners-workout.htmlDisclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Caloric balance1:34 Diet tips for healthy weight gain3:37 Exercise5:58 Recap8:16 Example foods10:37 Additional exercise tips
What do those Dates on our food REALLY mean?! Nutrition Made Simple! 2023-04-09 | Many people assume date labels mean food goes bad after that day. The reality is quite different and can help save money and time.Subscribe for more free nutrition and health tips: bit.ly/2toMJ9uConnect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaLinks:www.fsis.usda.gov/food-safety/safe-food-handling-and-preparation/food-safety-basics/food-product-datingwww.eufic.org/en/food-safety/article/best-before-use-by-and-sell-by-dates-explainedDisclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Different labels0:27 "Best by" and "Use by"0:51 "Sell by"1:31 One Exception2:32 Europe2:59 Recap
Dr Sten Ekberg gets fact-checked by MD PhD Doctor Nutrition Made Simple! 2023-04-03 | Dr. Sten Ekberg´s video "Your doctor is wrong about cholesterol" analyzed and commented. Dr. Ekberg´s claims compared to the available scientific evidence. Do Dr. Sten Ekberg´s ideas stand up to scrutiny?Connect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3original video:www.youtube.com/watch?v=sY48qLl9ZzEReferences (copy/paste onto your browser):1-shorturl.at/opxGL2-jacc.org/doi/10.1016/j.jacc.2019.03.0103-shorturl.at/fyN124-europepmc.org/articles/pmc2988224/bin/mmc1.pdf5-shorturl.at/biqM06-nejm.org/doi/full/10.1056/NEJM1998110533919027-shorturl.at/bzACN8-nejm.org/doi/full/10.1056/nejm1995111633320019-nejm.org/doi/full/10.1056/NEJMoa080764610-shorturl.at/dmBP211-shorturl.at/isNWZ12-shorturl.at/hjlINbmj.com/content/306/6882/890.short13-link.springer.com/article/10.1007/s00508-019-01544-5tandfonline.com/doi/abs/10.1080/03610739824430014-shorturl.at/BFZ16degruyter.com/document/doi/10.1515/hsz-2014-0194/htmleuropepmc.org/article/med/320288415-bmj.com/content/371/bmj.m426616-nature.com/articles/s41598-018-38461-y17-shorturl.at/IRTY518-sciencedirect.com/science/article/pii/S0735109719349319shorturl.at/nsuQ3academic.oup.com/ije/article/44/2/604/75317119-nejm.org/doi/full/10.1056/NEJMoa070662820-academic.oup.com/eurheartj/article/39/14/1172/456249321-nejm.org/doi/pdf/10.1056/nejmoa221502422-shorturl.at/ekxzU23-shorturl.at/cpxzRjamanetwork.com/journals/jama/article-abstract/19911824-shorturl.at/rwCPU25-link.springer.com/chapter/10.1007/978-3-030-56514-5_2926-shorturl.at/aiGYZ27-sciencedirect.com/science/article/pii/S0735109717412320jamanetwork.com/journals/jama/fullarticle/274953328-nejm.org/doi/full/10.1056/NEJMoa170791429-shorturl.at/psxEO30-shorturl.at/owyzE31-pubmed.ncbi.nlm.nih.gov/2545865132-sciencedirect.com/science/article/pii/S016882270900433133-link.springer.com/chapter/10.1007/3-540-32232-9_234-sciencedirect.com/science/article/abs/pii/000293439290620Q35-ncbi.nlm.nih.gov/pmc/articles/PMC502369936-shorturl.at/sxBQ337-sciencedirect.com/science/article/pii/009174358490037938-pubmed.ncbi.nlm.nih.gov/1694948939-jacc.org/doi/10.1016/j.jacc.2006.06.00140-pubmed.ncbi.nlm.nih.gov/3388372841-jacc.org/doi/abs/10.1016/j.jacc.2020.10.04842-jacc.org/doi/10.1016/j.jacc.2022.10.01143-jacc.org/doi/full/10.1016/j.jcmg.2014.06.02144-pubmed.ncbi.nlm.nih.gov/2747240945-shorturl.at/elzNO46-shorturl.at/mCFO647-shorturl.at/csJKY48-shorturl.at/ejCZ249-ncbi.nlm.nih.gov/pmc/articles/PMC410351450-europepmc.org/article/med/1032225251-onlinelibrary.wiley.com/doi/full/10.1111/jch.1275852-shorturl.at/cmnyG53-shorturl.at/cdxC854-pubmed.ncbi.nlm.nih.gov/2436235655-onlinelibrary.wiley.com/doi/full/10.1111/joim.1261456-ncbi.nlm.nih.gov/pmc/articles/PMC292481257-jlr.org/article/S0022-2275(20)30768-9/fulltext58-journals.physiology.org/doi/abs/10.1152/ajpgi.00215.201059-pubmed.ncbi.nlm.nih.gov/1536178560-ncbi.nlm.nih.gov/pmc/articles/PMC292481261-shorturl.at/bsHS562-shorturl.at/cxV3663-ncbi.nlm.nih.gov/sites/books/NBK30589664-lipidjournal.com/article/S1933-2874(21)00248-8/fulltext65-academic.oup.com/jcem/article/88/10/4525/284568166-link.springer.com/article/10.1007/s11883-004-0050-567-shorturl.at/hmGU568-link.springer.com/book/10.1007/978-1-59745-533-669-jamanetwork.com/journals/jama/article-abstract/272277070-shorturl.at/otAM071-shorturl.at/kxSZ172-ahajournals.org/doi/10.1161/circheartfailure.114.00173073-link.springer.com/article/10.1186/1749-8090-4-61 74-ncbi.nlm.nih.gov/pmc/articles/PMC665271375-jamanetwork.com/journals/jama/article-abstract/219099476-ahajournals.org/doi/epdf/10.1161/ATV.000000000000007377-jacc.org/doi/10.1016/j.jacc.2021.07.02278-shorturl.at/rER0679-sciencedirect.com/science/article/pii/S016752731632483480-nejm.org/doi/full/10.1056/NEJMoa221502481-shorturl.at/ghpyQ82-shorturl.at/lJX3483-shorturl.at/joxBQ84-shorturl.at/eprH785-shorturl.at/fqJT186-thelancet.com/article/S0140-6736(16)31357-5/fulltext87-ncbi.nlm.nih.gov/pmc/articles/PMC377402288-shorturl.at/kuOZ989-ncbi.nlm.nih.gov/pmc/articles/PMC4593072Disclaimer: Contents are for informational purposes only, and not meant as medical advice. Always seek the advice of your physician. Never disregard medical advice.#NutritionMadeSimple #GilCarvalho0:00 Intro1:19 Cholesterol4:03 COIs4:25 Statins5:02 Statins & heart disease6:56 Cholesterol & mortality10:35 Why are statins prescribed12:38 Funding15:24 Relative & Absolute risk19:10 Correlation vs causation24:08 The basics of Heart Disease28:07 Inflammation29:00 Insulin Resistance30:25 Oxidative Stress36:48 HDL-C37:54 Ratios40:19 Cholesterol in blood vs whole body42:16 oxLDL clearance46:17 Artery damage & retention52:28 LDL number & size59:44 Statins & LDL1:03:53 Statin side effects1:04:48 Cardiomegaly1:08:05 Statins & muscle1:11:29 Liver1:11:52 Brain1:15:11 Statins & diabetes1:17:35 Sugar & diet1:19:11 Final remarks
Climate Change and our Food Choices | Dr. Matthew Hayek Nutrition Made Simple! 2023-03-27 | Follow Dr. Hayek:Twitter: @matthewhayekhttps://as.nyu.edu/faculty/matthew-hayek.htmlhttp://www.matthewhayek.comConnect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Links:1-journaljsrr.com/index.php/JSRR/article/view/8302-agupubs.onlinelibrary.wiley.com/doi/abs/10.1029/99EO003253-www.metoffice.gov.uk/hadobs/hadcrut54-www.nature.com/articles/s41586-020-2591-35-www.nature.com/articles/s41598-017-14828-56-www.carbonbrief.org/analysis-why-scientists-think-100-of-global-warming-is-due-to-humans7-www.epa.gov/climatechange-science/causes-climate-change8-www.ipcc.ch/site/assets/uploads/2018/02/ar4_syr_full_report.pdf9-www.methanelevels.org10-berkeleyearth.org/dv/10000-years-of-carbon-dioxide11-www.ncbi.nlm.nih.gov/pmc/articles/PMC775724512-www.nature.com/articles/s41561-019-0394-713-science2017.globalchange.gov/downloads/CSSR2017_FullReport.pdf14-https://climate.ec.europa.eu/climate-change/consequences-climate-change_en15-link.springer.com/article/10.1007/s42398-019-00078-w16-www.nature.com/articles/nature1130017-science2017.globalchange.gov/downloads/CSSR2017_FullReport.pdf18-onlinelibrary.wiley.com/doi/abs/10.1111/j.1539-6924.2005.00694.x19-www.nber.org/system/files/working_papers/w26167/w26167.pdf20-www.science.org/doi/full/10.1126/sciadv.aba455121-www.nature.com/articles/nature1979822-www.sciencedirect.com/science/article/abs/pii/S001282522100002723-www.nature.com/articles/s41598-022-12842-w24-www.mdpi.com/2075-4450/12/8/68825-www.cabdirect.org/cabdirect/abstract/2011319039026-https://unfccc.int/process-and-meetings/the-paris-agreement/the-paris-agreement27-www.nature.com/articles/nclimate309628-agupubs.onlinelibrary.wiley.com/doi/abs/10.1002/2017GL07622229-www.science.org/doi/abs/10.1126/science.abn795030-www.ipcc.ch/sr15/faq/faq-chapter-1/31-time.com/6213489/remove-carbon-emissions-from-air32-https://climate.mit.edu/ask-mit/which-parts-planet-are-warming-fastest-and-why33-www.nature.com/articles/s41598-022-21060-334-www.sciencedirect.com/science/article/pii/B978044453301200007535-www.sciencedirect.com/science/article/pii/B978012821575300015336-www.nature.com/articles/s41579-019-0222-537-https://climate.ec.europa.eu/climate-change/consequences-climate-change_en38-www.nature.com/articles/s41558-018-0315-639-www.nature.com/articles/ncomms965740-pubs.acs.org/doi/full/10.1021/bk-2011-1089.ch00141-www.usda.gov/media/blog/2019/07/29/corn-americas-largest-crop-201942-https://cropwatch.unl.edu/2019/how-extended-high-heat-disrupts-corn-pollination43-www.sciencedirect.com/science/article/abs/pii/S016819232100061744-www.pnas.org/doi/10.1073/pnas.201017911745-www.jrf.org.uk/sites/default/files/jrf/migrated/files/climate-change-social-justice-summary.pdf46-www.tandfonline.com/doi/abs/10.1080/0894192050051925547-link.springer.com/article/10.1007/s10708-022-10768-448-www.emerald.com/insight/content/doi/10.1016/S0196-1152(07)15005-5/full/html49-www.bbc.com/news/world-asia-6283077150-https://unfccc.int/sites/default/files/NDC/2022-06/Pakistan%20Updated%20NDC%202021.pdf51-www.nytimes.com/2022/08/01/climate/wildfire-risk-california-west.html52-http://surl.li/fbwgo53-http://surl.li/fbwgu54-http://surl.li/fbwgr55-agupubs.onlinelibrary.wiley.com/doi/pdf/10.1029/2018EF00092256-www.congress.gov/bill/117th-congress/house-bill/5376/text57-content.rewiringamerica.org/reports/Clean%20Energy%20Provisions.pdf58-http://surl.li/fbwhc59-productiongap.org/wp-content/uploads/2019/11/Production-Gap-Report-2019.pdf60-www.science.org/doi/abs/10.1126/science.aaq021661-iopscience.iop.org/article/10.1088/1748-9326/ac018e/meta62-www.fao.org/3/cb3808en/cb3808en.pdf63-science.sciencemag.org/content/370/6517/70564-pubs.acs.org/doi/10.1021/es702969f65-iopscience.iop.org/article/10.1088/1748-9326/aa6cd5/pdf66-https://rb.gy/8zlrcl67-www.ncbi.nlm.nih.gov/pmc/articles/PMC261425568-link.springer.com/article/10.1007/s10021-022-00776-369-www.nature.com/articles/s43247-020-00017-270-www.mdpi.com/2076-2615/11/4/95171-iopscience.iop.org/article/10.1088/1748-9326/abf9c8/meta72-http://surl.li/fbwgy73-www.edf.org/climate/methane-crucial-opportunity-climate-fightDisclaimer: The contents are for informational purposes only. Always seek the advice of your physician or qualified health provider.#NutritionMadeSimple #GilCarvalho0:00 Intro1:08 What is climate change4:31 Isn't climate variation normal?8:20 Climate goals12:00 Do a couple degrees really matter?16:00 Expected consequences19:30 Climate injustice21:45 Is there still time?22:38 Is it all a hoax?24:43 What causes climate change? Agriculture vs fossil fuels32:34 Climate impact of different foods35:58 Methane37:22 Conclusion
The New Weight Loss Drugs OZEMPIC, MOUNJARO (semaglutide, tirzepatide) | Dr. Spencer Nadolsky Nutrition Made Simple! 2023-03-20 | Weight loss drugs Ozempic, Wegovy and Mounjaro have been all over the headlines. What do they do, how do they work and are they safe? A look at Ozempic, Wegovy and Mounjaro (Semaglutide & tirzepatide, GLP-1 mimetics) for obesity and weight loss.Dr. Nadolsky:Twitter: twitter.com/DrNadolskydrspencer.comIG: @drnadolskyConnect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1-sciencedirect.com/science/article/abs/pii/S22138587150048292-journals.physiology.org/doi/full/10.1152/ajpendo.1997.273.5.E9813-link.springer.com/article/10.1007/s11154-014-9289-54-nature.com/articles/nrd18285-nejm.org/doi/full/10.1056/NEJMoa2032183nejm.org/doi/full/10.1056/NEJMoa22060386-jamanetwork.com/journals/jama/article-abstract/27879077-sciencedirect.com/science/article/pii/S10432760203004858-hindawi.com/journals/jdr/2012/7640179-dom-pubs.onlinelibrary.wiley.com/doi/full/10.1111/dom.1455110-frontiersin.org/articles/10.3389/fphar.2018.00576/full11-journals.sagepub.com/doi/pdf/10.1177/019262331247240212-frontiersin.org/articles/10.3389/fendo.2021.645563/full13-nejm.org/doi/full/10.1056/NEJMoa203218314-ncbi.nlm.nih.gov/pmc/articles/PMC808928715-dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.1472516-nature.com/articles/s41591-022-02026-4Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Intro0:26 COIs3:14 New weight loss drugs9.32 Efficacy11:06 Dual effect of tirzepatide13:49 What patients report17:30 Stigma and perception22:34 Obesity and the brain23:46 Side effects34:45 Fat mass vs lean mass41:24 Do you have to take them forever?
Oxalates & Kidney stones | Dr. David Goldfarb, MD Nutrition Made Simple! 2023-03-13 | Nephrologist Dr. David Goldfarb, MD goes over the science on kidney stones and oxalates.Dr. Goldfarb on Twitter: @weddelliteConnect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3References:1-www.sciencedirect.com/science/article/pii/S15485595120022122-www.ncbi.nlm.nih.gov/pmc/articles/PMC29312863-europepmc.org/article/NBK/nbk2790694-www.ncbi.nlm.nih.gov/pmc/articles/PMC5685519www.ncbi.nlm.nih.gov/pmc/articles/PMC72651845-jamanetwork.com/journals/jama/article-abstract/2002486-academic.oup.com/advances/article-abstract/13/3/821/6530640link.springer.com/article/10.1186/1479-5876-11-1097-www.sciencedirect.com/science/article/pii/S15485595120022128-www.sciencedirect.com/science/article/pii/S008525381554739Xeuropepmc.org/article/med/111320329-www.ncbi.nlm.nih.gov/pmc/articles/PMC735373610-www.mdpi.com/2072-6643/11/5/118211-link.springer.com/article/10.1007/s00125-015-3650-412-pubmed.ncbi.nlm.nih.gov/2343937613-pubmed.ncbi.nlm.nih.gov/2451878914-link.springer.com/article/10.1007/s10654-014-9904-515-pubmed.ncbi.nlm.nih.gov/858358816-pubmed.ncbi.nlm.nih.gov/1515356717-pubmed.ncbi.nlm.nih.gov/1256362218-www.nejm.org/doi/full/10.1056/NEJM19930325328120319-www.nejm.org/doi/10.1056/NEJMoa01036920-academic.oup.com/ajcn/article-abstract/62/4/740/4651100europepmc.org/article/med/1096868320*-jamanetwork.com/journals/jama/article-abstract/200248link.springer.com/article/10.1007/s10654-018-0426-421-jamanetwork.com/journals/jama/article-abstract/170050122-pubmed.ncbi.nlm.nih.gov/3189516223-www.sciencedirect.com/science/article/abs/pii/S0272638612806251www.sciencedirect.com/science/article/pii/S0085253815474629www.mdpi.com/2072-6643/12/3/779/htm#B54-nutrients-12-0077924-www.sciencedirect.com/science/article/pii/S0085253815518838www.sciencedirect.com/science/article/pii/S008525381547723325-aspenjournals.onlinelibrary.wiley.com/doi/abs/10.1002/ncp.1011326-www.auajournals.org/doi/abs/10.1016/j.juro.2009.02.02927-www.sciencedirect.com/science/article/pii/S246802492031537028-www.sciencedirect.com/science/article/pii/S008525381531205929-pubmed.ncbi.nlm.nih.gov/3428195830-nutritionj.biomedcentral.com/articles/10.1186/s12937-022-00773-131-pubmed.ncbi.nlm.nih.gov/3083016732-pubmed.ncbi.nlm.nih.gov/2974832933-www.liebertpub.com/doi/abs/10.1089/end.2011.024334-academic.oup.com/ndt/article/26/11/3609/182994335-link.springer.com/article/10.1007/s00467-022-05591-536-pubmed.ncbi.nlm.nih.gov/1769949137-www.ncbi.nlm.nih.gov/pmc/articles/PMC321043238-www.auajournals.org/doi/abs/10.1097/JU.0000000000002010.07moonstonenutrition.com/pages/meet-the-team39-www.sciencedirect.com/science/article/abs/pii/S1051227621000935www.sciencedirect.com/science/article/pii/S002253471303862740-www.sciencedirect.com/science/article/pii/S008525381551883841-www.mdpi.com/2072-6643/13/2/528#B13-nutrients-13-00528www.sciencedirect.com/science/article/abs/pii/S009042951630501542-www.sciencedirect.com/science/article/pii/S008525381547723343-academic.oup.com/jcem/article-abstract/66/1/140/2651755academic.oup.com/aje/article/143/5/472/8571244-onlinelibrary.wiley.com/doi/abs/10.1002/art.2076145-www.cmaj.ca/content/174/10/1407.short46-www.sciencedirect.com/science/article/pii/S008525381549720046*-pubmed.ncbi.nlm.nih.gov/1557952647-pubmed.ncbi.nlm.nih.gov/1967967248-pubmed.ncbi.nlm.nih.gov/779781049-www.karger.com/Article/Abstract/356559www.sciencedirect.com/science/article/pii/S027263862100712550-link.springer.com/article/10.1007/s00345-020-03561-w51-journals.lww.com/cjasn/pages/articleviewer.aspxwww.sciencedirect.com/science/article/abs/pii/S089990072200331852-www.sciencedirect.com/science/article/pii/S154855951200221253-www.sciencedirect.com/science/article/abs/pii/S002253470561684954-onlinelibrary.wiley.com/doi/abs/10.1111/j.1530-0277.1995.tb01579.x55-www.mdpi.com/2072-6643/12/5/144256-www.mdpi.com/2072-6643/13/1/6257-www.auajournals.org/doi/abs/10.1016/S0022-5347%2805%2966142-358-pubmed.ncbi.nlm.nih.gov/3203268759-pubmed.ncbi.nlm.nih.gov/1075188960-link.springer.com/article/10.1007/BF0026234961-www.ncbi.nlm.nih.gov/pmc/articles/PMC388308262-pubmed.ncbi.nlm.nih.gov/229971263-www.ncbi.nlm.nih.gov/pmc/articles/PMC9267091pubmed.ncbi.nlm.nih.gov/3298103264-www.ncbi.nlm.nih.gov/pmc/articles/PMC221388965-pubmed.ncbi.nlm.nih.gov/17094744Disclaimer: The contents are for informational purposes only, not intended as medical advice nor to replace medical care. Never disregard medical advice because of information in Nutrition Made Simple.#NutritionMadeSimple #GilCarvalho0:00 Intro2:02 Why do kidney stones form?14:57 Age of onset & symptoms20:02 Oxalate sources27:04 Oxalate conditions35:02 Oxalates & the microbiome40:33 Citrate & calcium45:15 Animal protein50:53 Diet for kidney stone prevention57:38 Supplements1:04:49 What to do if you're passing a kidney stone
Bempedoic Acid (Nexletol) reduces Heart Attacks | New trial Nutrition Made Simple! 2023-03-06 | A new trial reports Bempedoic Acid (Nexletol) reduces heart attacks by 23%. Let's take a look at the study and the pros and cons of Bempedoic Acid (Nexletol). Will Bempedoic Acid (Nexletol) replace statins for cardiovascular disease and heart disease management?Connect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1-nejm.org/doi/full/10.1056/NEJMe23007932-nejm.org/doi/full/10.1056/NEJMc20311733-nejm.org/doi/full/10.1056/NEJMoa22150244-nejm.org/doi/full/10.1056/NEJMoa22150245-europepmc.org/articles/pmc2988224/bin/mmc1.pdf6-nejm.org/doi/full/10.1056/NEJMoa18067477-europepmc.org/articles/pmc2988224/bin/mmc1.pdfDisclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 New trial0:20 What is bempedoic acid?2:17 How was the study done?4:36 Results6:40 What the results mean9:24 Side effects11:05 Mortality12:12 Funding14:38 My COIs15:25 Summary and implications
Does the sweetener Erythritol cause Heart Disease?? | New study Nutrition Made Simple! 2023-03-02 | Does erythritol cause heart disease? A new study suggests a link between the low-calorie sweetener erythritol and cardiovascular risk and it generated a media storm. Let's take a look at the study and what we know about erythritol and its safety.Subscribe for more free nutrition and health tips: bit.ly/2toMJ9uConnect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1-nature.com/articles/s41591-023-02223-92-tandfonline.com/doi/pdf/10.1080/07388551.2017.13805983-pubmed.ncbi.nlm.nih.gov/32412980also: frontiersin.org/articles/10.3389/fnut.2022.953056/full4-ahajournals.org/doi/full/10.1161/ATVBAHA.118.3122365-ahajournals.org/doi/full/10.1161/ATVBAHA.118.3122366-mdpi.com/2072-6643/15/1/204#B74-nutrients-15-002047-sciencedirect.com/science/article/pii/S08999007090022758-clinicaltrials.gov/ct2/show/NCT047313639-sciencedirect.com/science/article/abs/pii/S0273230096901129 10-ncbi.nlm.nih.gov/pmc/articles/PMC4037362Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Intro0:43 New study5:18 Erythritol and clotting8:09 Social media reaction12:21 Take-home message
Should you wear a Continuous Glucose Monitor (CGM)? Nutrition Made Simple! 2023-02-27 | Should healthy people use CGMs? What about people with diabetes or pre diabetes? A look at the pros and cons of CGMs in each case.1st video with Dr. Guess: youtu.be/gdWe87YfFFcA continuous glucose monitor is a small device you can wear on your arm or belly and it measures your glucose levels continuously so you can see the change in real time after a meal for example.I discussed CGMs with with Dr. Nicola Guess, who received her PhD from Imperial College London for work in diabetes prevention and is currently Res Program Manager at Oxford Univ where she studies approaches for diabetes remission.In people with T2d there’s a role for CGMs. They can give immediate feedback and motivation. Always coupled with healthy diet. Be wary of exclusive focus on glucose. Just because a food flattens glucose doesn´t mean its health-promoting. Shoot for a holistic approachWith pre-diabetes: CGMs can help distinguish WHEN glucose is high. fasting vs post-prandialFor people with high fasting glucose but good post-prandia valuesl, dr. Guess mentions vigorous physical activity and high fiber dietsFor people with high post-prandial glucose (after meals), emphasizing protein and moderating carbs is one approach she utilizes routinely. Amino acids stimulate the pancreas to produce more insulin which helps control postprandial glucoseFor those without prediabetes or diabetes, the concern with generalized CGM use is excessive focus on glucose and the misunderstanding that glucose excursions are perniciousIt’s completely normal for glucose level to rise after a meal as long as it comes back down again. What’s unnatural is for it to stay high for a long period of time, suggesting the body struggles to process glucose normallySo it´s less about whether the CGM is good or bad and more about how we use the information.Connect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1-https://www.biomed.cas.cz/physiolres/pdf/62/62_163.pdf2-journals.humankinetics.com/view/journals/jpah/14/9/article-p745.xml3-academic.oup.com/ajcn/article-abstract/47/5/852/46946694-diabetesjournals.org/diabetes/article/39/4/501/7365/Effects-of-Prolonged-Pulsatile-Hyperinsulinemia-inDisclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 What is a CGM?0:48 CGMs for type 2 diabetics3:25 CGMs for prediabetics4:40 CGMs for healthy people7:46 Glucose in endurance athletes11:21 Summary
Red meat vs imitation meat, which is healthier? | Dr. Christopher Gardner, PhD Nutrition Made Simple! 2023-02-20 | Plant-based imitation meats have become a reality. What scientific evidence do we have on them? A look at the data on the health effect of plant-based imitation meats compared to red meat.Connect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1-pubmed.ncbi.nlm.nih.gov/327807942-cell.com/cell-metabolism/fulltext/S1550-4131(19)30248-73-nature.com/articles/nm.3145?ct=400124-diabetesjournals.org/diabetes/article/68/9/1747/39628/Assessment-of-Causal-Direction-Between-Gut5-nutritionj.biomedcentral.com/articles/10.1186/s12937-022-00820-x6-nutritionj.biomedcentral.com/articles/10.1186/1475-2891-12-867-jissn.biomedcentral.com/articles/10.1186/s12970-014-0064-58-pubmed.ncbi.nlm.nih.gov/331725069-mdpi.com/1660-4601/17/11/3871/htm10-frontiersin.org/articles/10.3389/fnut.2022.934438/fullDisclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Highlights0:10 Meat alternatives are now a reality1:12 The SWAP-MEAT trial6:34 Results8:56 TMAO11:34 Weight loss14:10 The SWAP-MEAT Athlete trial
Scientist tests ChatGPT on nutrition & health Nutrition Made Simple! 2023-02-13 | ChatGPT, OpenAI´s new chatbot, has exploded in popularity lately. How reliable is it when it comes to science, nutrition and health? I tested ChatGPT´s knowledge of nutrition and different medical issues.Connect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:openai.com/blog/chatgptDisclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Intro0:23 Best diet1:55 Eggs4:24 Dietary fats5:49 Curveball7:13 Diabetes8:21 HDL-C11:08 Myths12:48 Lectins15:13 Creativity16:04 Overall assessment
10 Nutrition MYTHS Experts Wish Would Die Nutrition Made Simple! 2023-02-06 | 10 common nutrition myths, from soy to plant milk to calories & weight loss.Connect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1-nytimes.com/2023/01/19/well/eat/nutrition-myths.html2-sciencedirect.com/science/article/abs/pii/S08891575173004183-cell.com/cell-metabolism/pdf/S1550-4131(19)30248-7.pdf4-bmj.com/content/347/bmj.f50015-ncbi.nlm.nih.gov/pmc/articles/PMC78848956-nutritionj.biomedcentral.com/articles/10.1186/1475-2891-12-297-pubs.rsc.org/en/content/articlelanding/2019/fo/c9fo01426h/unauth8-onlinelibrary.wiley.com/doi/abs/10.1002/ptr.71359-ncbi.nlm.nih.gov/pmc/articles/PMC8281151/#!po=38.888910-frontiersin.org/articles/10.3389/fnut.2022.988707/full#h911-ncbi.nlm.nih.gov/pmc/articles/PMC5486204/pdf/ajcn154872.pdf12-journals.plos.org/plosone/article?id=10.1371/journal.pone.021634813-link.springer.com/article/10.1007/s00394-018-1774-214-nejm.org/doi/10.1056/NEJMoa141485015-niaid.nih.gov/sites/default/files/addendum-peanut-allergy-prevention-guidelines.pdf16-onlinelibrary.wiley.com/doi/10.1111/all.1532417-https://www.mcri.edu.au/news-stories/researchers-discover-immune-system-changes-support-peanut-allergy-remission-children18-link.springer.com/article/10.1007/s40279-021-01434-919-pubmed.ncbi.nlm.nih.gov/3317250620-tandfonline.com/doi/full/10.1186/s12970-014-0064-521-iv.iiarjournals.org/content/invivo/36/2/556.full.pdf22-sciencedirect.com/science/article/abs/pii/S221226721930362423-https://koreascience.kr/article/JAKO201321251180903.pdf24-karger.com/Article/Pdf/44473525-ncbi.nlm.nih.gov/pmc/articles/PMC3192476Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Intro0:16 Frozen fruit & veg1:39 Dietary fat3:28 Calories & weight loss5:08 Type 2 diabetes and fruit10:08 Cow milk vs plant milk12:57 White potatoes14:07 Peanut allergies15:33 Plant protein16:39 Soy & breast cancer18:25 Nutrition keeps changing
Best Diet(s) for Type 2 Diabetes | Dr. Nicola Guess Nutrition Made Simple! 2023-01-30 | People report overcoming diabetes with completely different diets. Low carb, low fat, intermittent fasting etc. Can science explain this? A look at dietary approaches to prevention and remission of type 2 diabetes.Dr. Guess on social media:Twitter: @Dr__Guessphc.ox.ac.uk/team/nicola-guessdrguess.substack.comReferences:1-pubmed.ncbi.nlm.nih.gov/292216452-link.springer.com/article/10.1007/s13300-022-01220-43-nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-3-164-academic.oup.com/ajcn/article-abstract/32/11/2312/46921165-academic.oup.com/ajcn/article/101/6/1320S/45644926-portlandpress.com/biochemsoctrans/article-abstract/35/5/1180/85658/Amino-acid-metabolism-insulin-secretion-and7-sciencedirect.com/science/article/abs/pii/S074937971100465X8-link.springer.com/article/10.1007/s13300-018-0373-99-diabetesjournals.org/diabetes/article/51/3/599/34454/Mechanism-of-Amino-Acid-Induced-Skeletal-Muscle10-link.springer.com/article/10.1007/s11892-003-0034-911-ncbi.nlm.nih.gov/pmc/articles/PMC459860412-academic.oup.com/jcem/article/89/4/1641/284424113-academic.oup.com/jcem/article-abstract/52/1/34/267807614-academic.oup.com/ajcn/article-abstract/52/3/524/465082415-mdpi.com/2072-6643/7/11/5454Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Highlights0:21 Intro1:01 Clarifying diabetes3:11 Protein, insulin and diabetes11:28 Protein sources12:52 Individual variation15:30 Choosing the right diet20:10 Prevention vs management24:19 Insulin Resistance26:00 Low carb diets27:21 High carb diets29:00 Fat quality29:43 Conclusion & take-home messages
New Study Crushes “One Size Fits All” Diet? Nutrition Made Simple! 2023-01-23 | New diet trial looks at precision nutrition, the right diet for each person.Many diets can provide benefits. E.g. trials on low fat vs low carb show similar weight loss and metabolic improvements over the long run. Why do some people do better on diet A and others on diet B?Overweight volunteers split randomly between 2 diets with same amount of calories but differing in fat content. 34% of calories from fat vs 28%fat was replaced with protein. nutrition trials often try to keep protein constant because it affects satiation and intake. many nutrients affect satiation. Fat, fiber etc.Fiber: in the higher fat diet was a bit under 30g fiber a day and the lower fat diet was a bit over 30g. supplement of B-glucan (fiber in oats and barley).Other than that, carbs were kept constant. ~44% of calories from carb in both groupsthe fat they added was monounsaturated fat. PUFAs and SFA were kept constant at ~8% of calories eachthe higher fat diet had more olive oil and olives. the lower fat diet had more low fat dairy like low fat yogurt and cheese.They were on the diets for 3 monthsThey looked for improvements in metabolic parameters like fasting insulin, glucose & insulin after a meal, triglycerides and markers of inflammationSome people improved on the lower fat diet, some on the higher fat diet.Insulin resistance= when organs don´t respond normally to insulin so they resist taking up glucose from circulationYou can have insulin resistance in the liver while muscles are still more insulin sensitive. they estimated Insulin resistance in liver and muscle. people with Insulin resistance in the liver predominantly did better on the higher fat diet. metabolic parameters improved. on the lower fat diet there was no significant change. with muscle Insulin resistance they saw improvement on the lower fat diet, no significant change on higher fatchanges in the microbiome? unsaturated fat improves liver function so its good for liver Insulin resistance?caloriess didnt differ significantly. changes didn´t seem to be explained by overall weight loss. there was a small weight loss of ~2% in all groups, weight loss per se didn´t explain it. Fat loss trended. Visceral fat didnt appear differentgynoid fat, fat accumulated in the hips, thighs and breasts, differed significantly. muscle Insulin resistance lost more gynoid fat on lower fat diet and saw metabolic improvements on that diet. liver Insulin resistance= less gynoid fat and better metabolic markers on higher fatprecision nutrition is in its infancyConnect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1-jamanetwork.com/journals/jama/fullarticle/26731502- the new trial cell.com/cell-metabolism/fulltext/S1550-4131(22)00539-33-vox.com/2016/11/2/13453434/personalized-diet-nutrition-dna4-pubmed.ncbi.nlm.nih.gov/24439821Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 What is Precision Nutrition?1:09 New trial4:08 The results6:05 Body weight and body fat7:40 What does it mean?8:26 Is Precision Nutrition ready for the limelight?10:00 Best of both worlds
Fiber vs Fermented Foods, which is healthier? | Dr. Christopher Gardner Nutrition Made Simple! 2023-01-16 | Why do some people have difficulty digesting fiber-rich foods? Are fermented foods easier on the stomach? A recent trial compares fiber-rich to fermented foods. We go over the findings and discuss strategies to address fiber intolerance.Connect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1- cell.com/cell/fulltext/S0092-8674(21)00754-6Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Highlights0:15 Fiber intolerance, a seminal study4:06 The surprising effect of fermented foods4:54 Fiber tolerant vs fiber intolerant6:23 Strategies for gut health and fiber intolerance7:22 Inflammation8:44 How to (re)introduce fiber
Should we eat like our ancestors? | Dr. Peter Ungar, PhD Nutrition Made Simple! 2023-01-09 | Ancestral diets have become popular, but are they healthy? Should we try to eat like our prehistoric ancestors? A look at the science behind ancestral diets.Follow Dr. Ungar:https://ungarlab.uark.edu/twitter.com/PeterSUngarfacebook.com/profile.php?id=20618583Connect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1-researchgate.net/profile/Tatiana-Giraud/publication/259107570_The_domestication_and_evolutionary_ecology_of_apples/links/5d7e286f92851c87c389f347/The-domestication-and-evolutionary-ecology-of-apples.pdf2-bsapubs.onlinelibrary.wiley.com/doi/full/10.3732/ajb.10005223-sciencedirect.com/science/article/abs/pii/B97804444270385001784-pnas.org/doi/full/10.1073/pnas.11020011085-smithsonianmag.com/arts-culture/taming-the-wild-banana-339851036-scientificamerican.com/article/cooking-up-bigger-brains7-sciencedirect.com/science/article/abs/pii/S030162269800147X8-pnas.org/doi/full/10.1073/pnas.21219781199-smithsonianmag.com/smart-news/researchers-pinpoint-date-when-chickens-were-first-domesticated-18098021210-nature.com/articles/s41598-021-81589-7royalsocietypublishing.org/doi/10.1098/rspb.2021.039211-sciencedirect.com/science/article/pii/S003257911938550512-ncbi.nlm.nih.gov/pmc/articles/PMC630469413-https://www.publish.csiro.au/ebook/chapter/9781486301614_Chapter314-mdpi.com/1424-2818/6/4/70515-ncbi.nlm.nih.gov/books/NBK21652816-frontiersin.org/articles/10.3389/fgene.2022.841252/full17-onlinelibrary.wiley.com/doi/abs/10.1046/j.1467-3010.2000.00019.x18-papers.ssrn.com/sol3/papers.cfm?abstract_id=56374119-europepmc.org/article/med/727199820-bbc.com/future/article/20181002-how-long-did-ancient-people-live-life-span-versus-longevity21-pnas.org/doi/abs/10.1073/pnas.040285710122-tandfonline.com/doi/abs/10.3109/03014460.2015.104648823-sciencedirect.com/science/article/abs/pii/S004724841300225X24-science.org/doi/abs/10.1126/science.123848425-anatomypubs.onlinelibrary.wiley.com/doi/full/10.1002/ar.a.2037926-pnas.org/doi/pdf/10.1073/pnas.090261410627-https://humanorigins.si.edu/evidence/human-fossils/fossils/shanidar-128-link.springer.com/article/10.1007/s00239-019-09923-229-aafp.org/pubs/afp/issues/2002/0501/p1845.html?ref=Guzels.TV30-https://www.journals.uchicago.edu/doi/abs/10.1086/20435031-science.org/doi/abs/10.1126/science.123682832-https://www.journals.uchicago.edu/doi/abs/10.1086/68258733-science.org/doi/full/10.1126/science.283.5410.200434-ncbi.nlm.nih.gov/pmc/articles/PMC12489535-https://www.scielo.br/j/bjg/a/FxXZ7LPBDmZxjKKVbPym4Vb/abstract/?lang=en36-royalsocietypublishing.org/doi/full/10.1098/rspb.2021.274737-newscientist.com/article/2350008-homo-naledi-may-have-used-fire-to-cook-and-navigate-230000-years-ago38-nature.com/articles/s41559-022-01910-z39-nature.com/articles/nature.2012.1037240-https://www.journals.uchicago.edu/doi/full/10.1086/69253041-scientificamerican.com/article/ancient-cutmarks-reveal-butchery42-nature.com/articles/news.2010.39943-science.org/cms/asset/8a46c64c-1c86-4079-a4f5-ea4f27654feb/pap.pdf44-science.org/doi/abs/10.1126/science.114546345-sciencedaily.com/releases/2002/07/020705090840.htm46-onlinelibrary.wiley.com/doi/am-pdf/10.1002/ajpa.2375947-onlinelibrary.wiley.com/doi/full/10.1002/ajpa.1039948-royalsocietypublishing.org/doi/full/10.1098/rspb.2013.033849-science.org/content/article/ancient-tools-may-shed-light-mysterious-hobbit50-science.org/doi/full/10.1126/science.306.5697.78951-nature.com/articles/459041a52-nature.com/articles/nature0884453-nature.com/articles/s41598-022-23310-wDisclaimer: Contents are for informational purposes only and not intended as medical advice nor to replace medical care. The information is accurate and conforms to available scientific evidence to the best of the author's knowledge at the time of posting. Never disregard professional medical advice or delay seeking it.#NutritionMadeSimple #GilCarvalho0:00 Highlights0:32 Intro1:58 Which foods are "ancestral"?5:19 Did all our ancestors die young?8:54 Are ancestral foods healthy?13:25 Antagonistic pleiotropy14:38 The evolution of human brains18:42 The discovery of fire19:40 Meat and brains21:24 Brain size & intelligence23:04 Paleoanthropology and nutrition27:14 Recap & Conclusion29:05 Should we eat "ancestral" foods?
What our ancestors ate (and how we know it) | Dr. Peter Ungar, PhD Nutrition Made Simple! 2023-01-02 | So-called "ancestral diets" have become popular, but what did our prehistoric ancestors actually eat? Paleoanthropology researcher Dr. Peter Ungar takes us on a journey through the origins of our species and how scientists decipher the diets of our distant ancestors.Dr. Ungar´s Social Media links:https://ungarlab.uark.edu/twitter.com/PeterSUngarfacebook.com/profile.php?id=20618583Connect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1-degruyter.com/document/doi/10.7312/hard92188/html2-onlinelibrary.wiley.com/doi/full/10.1002/ece3.50493-pnas.org/doi/full/10.1073/pnas.13058271104-scientificamerican.com/article/the-real-paleo-diet5-nature.com/articles/s41598-019-41033-36-pnas.org/doi/10.1073/pnas.16078721137-science.sciencemag.org/content/326/5960/1680.full8-blogs.scientificamerican.com/observations/humans-feasting-on-grains-for-at-least-100000-years9-pnas.org/content/112/39/12075.abstract10-nationalgeographic.com/culture/article/ancient-oat-discovery-may-poke-more-holes-in-paleo-diet11-science.sciencemag.org/content/367/6473/8712-nature.com/articles/d41586-021-01681-w13-cambridge.org/core/journals/antiquity/article/cooking-in-caves-palaeolithic-carbonised-plant-food-remains-from-franchthi-and-shanidar/0CB510C9E528CD7AD923469D78E14E4214-edition.cnn.com/2022/11/22/world/prehistoric-diets-plants-neanderthals-scn15-https://insider.si.edu/2011/01/starch-grains-found-on-neandertal-teeth-helps-debunk-theory-their-extinction-was-caused-by-dietary-deficiencies/16-pnas.org/doi/10.1073/pnas.101686810817-pnas.org/doi/full/10.1073/pnas.202165511818-science.org/content/article/neanderthals-carb-loaded-helping-grow-their-big-brains19-sciencedirect.com/science/article/abs/pii/S004724841500165720-journals.plos.org/plosone/article?id=10.1371/journal.pone.020436821-pnas.org/doi/full/10.1073/pnas.100599210722-sciencedirect.com/science/article/pii/S004724840800156523-scientificamerican.com/article/the-real-paleo-diet24-reuters.com/article/us-science-neanderthals-idUSKBN16F2LK25-nature.com/articles/nature21674?dom=pscau&src=syn26-pnas.org/doi/10.1073/pnas.130730811027-journals.sagepub.com/doi/abs/10.1177/002203451882298128-sciencedirect.com/science/article/pii/S003101820600235529-journals.plos.org/plosone/article?id=10.1371/journal.pone.000204430-pnas.org/doi/10.1073/pnas.180943911531-blogs.scientificamerican.com/guest-blog/the-true-human-diet32-bbc.com/news/science-environment-2798170233-journals.plos.org/plosone/article?id=10.1371/journal.pone.010104534-nature.com/articles/s41586-021-03675-035-cambridge.org/core/journals/antiquity/article/abs/new-evidence-for-the-processing-of-wild-cereal-grains-at-ohalo-ii-a-23-000yearold-campsite-on-the-shore-of-the-sea-of-galilee-israel/3F1C519692D8923D4FD321001CB8735936-sciencedirect.com/science/article/abs/pii/S004724848471043837-link.springer.com/article/10.1007/s11434-011-4718-238-sciencedirect.com/science/article/pii/S030544038471080639-sciencedirect.com/science/article/abs/pii/030544038790004540-amazon.com/Edible-Insects-Human-Evolution-Lesnik/dp/081305699341-academic.oup.com/ae/article/64/4/261/523271142-pnas.org/doi/10.1073/pnas.98.4.1358Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Highlights0:25 What did our ancestors eat?2:15 Is there ONE ancestral diet?5:47 Diversity & uncertainty9:01 Did Neanderthals eat whole grains?10:34 Bone marks, teeth and DNA17:27 The chemical signature of diet19:45 Tooth microwear21:00 Putting the evidence together29:53 Patterns in human diet evolution35:19 Fossilized feces36:25 Omnivores, carnivores or herbivores?40:08 Hunting vs scavenging44:31 Eating insects46:05 Recap & Conclusion
Whats the BEST diet for humans? | Dr. Christopher Gardner, PhD Nutrition Made Simple! 2022-12-26 | What's the healthiest diet for humans? Why does this question seem so controversial and difficult to answer? Stanford researcher Dr. Christopher Gardner addresses his findings, sources of variability and conclusions of a 20+ year career studying human nutrition.Connect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1-jamanetwork.com/journals/jama/fullarticle/2673150?redirect=true2-jamanetwork.com/journals/jama/fullarticle/27517193-nejm.org/doi/full/10.1056/NEJMoa08047484-ahajournals.org/doi/full/10.1161/01.cir.0000437739.71477.ee5-sciencedirect.com/science/article/pii/S2666379122004347Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Highlights0:21 Is there a best diet for humans?1:04 The foundational diet7:33 Carbs, fat & protein12:17 Why is it so hard to stick to a diet??21:11 Human variability in nutrition24:50 Additional factors for success27:35 Insulin and hunger
What Your TRIGLYCERIDE Levels Mean | New Trial Nutrition Made Simple! 2022-12-19 | Triglycerides are often misunderstood. We look at new evidence on triglyceride lowering and heart disease. An overview of the value and caveats of trigliceryde levels New trial on triglyceride lowering. triglyceride-lowering drug vs placebo. participants: high triglycerides, low HDL-cholesterol. LDL-cholesterol was low, only triglycerides were highfibrate reduced triglycerides. HDL-cholesterol went up by 5%no significant change in risk of cardiovascular events (heart attack, stroke or death). why wasn’t risk lower if triglycerides came down?Lipids like triglycerides and cholesterol are carried in our bloodstream in lipoproteins like LDL and VLDL. VLDLs carry mostly triglycerides, LDLs carry mostly cholesterol. in cardiovascular research risk follows number of lipoproteins, not lipid level. so cholesterol and triglycerides are markersusually the higher the cholesterol and triglycerides, the more lipoproteins. VLDLs and LDLs are cousins. VLDLs can turn into LDLs. both carry ApoBthe fibrate didn't reduce apoB so risk didnt go down, regardless of what happens to triglycerides or cholesterol. fibrates lower VLDLs (which carry mostly TGs). So both triglycerides and their carriers go down. But it raises large LDLsVLDLs were reduced by being converted into LDLs. Reducing triglycerides by transforming one ApoB lipoprotein, VLDLs, into another, LDLs, is not helpfulOther trials: lowering triglycerides without lowering apoB doesnt helpgenetics: triglyceride levels have little if any effect on cardiovascular risk when we account for ApoBraising HDL-cholesterol doesn´t help; triglycerides and HDL-cholesterol combined play small if any role in cardiovascular risk accounting for apoB; people with good triglycerides and HDL-cholesterol can still have plaque in their arteriestriglycerides associate with risk at population level; higher triglycerides associate with higher risk; lowering them doesn’t necessarily lower risk high triglycerides reflect overweight, diabetes etc. changing triglycerides directly doesnt necessarily do muchmarkers vs makers. triglycerides, HDL-cholesterol (tracks well with risk but changing HDL-c directly makes little difference), LDL-cholesteroltriglycerides/HDL-cholesterol, total cholesterol/HDL-cholesterol, reflect obesity, diabetes but higher HDL-cholesterol genetically doesn´t affect risktriglycerides can come down without change to apoBhigh triglycerides: chances are i´m overweight or diabetic; if triglycerides come down due to weight loss, they reflect positive changevery high triglycerides can be bad news besides heart disease. pancreatitis and fatty liver. don´t ignore high triglycerides. but don’t assume lower triglycerides mean lower heart disease risk; also can’t assume low triglycerides mean safety. could still have determinants of cardiovascular risk out of whack, like high blood pressure or high ApoBfibrates reduce triglycerides and VLDLs yet risk wasn´t lowerConnect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1-nejm.org/doi/full/10.1056/NEJMoa22106452-jamanetwork.com/journals/jamacardiology/article-abstract/27863343-jamanetwork.com/journals/jama/article-abstract/27688504-jamanetwork.com/journals/jama/article-abstract/27227705-nejm.org/doi/full/10.1056/NEJMe22132086-pubmed.ncbi.nlm.nih.gov/338709317-link.springer.com/book/10.1007/978-1-59745-533-68-elifesciences.org/articles/58361#s39-ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.119.04199810-jamanetwork.com/journals/jama/article-abstract/272277011-journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.100306212-ncbi.nlm.nih.gov/pmc/articles/PMC410351413-academic.oup.com/ije/article/50/3/893/594881914-sciencedirect.com/science/article/pii/S073510971741232015-academic.oup.com/eurheartj/article/41/1/111/555635316-academic.oup.com/eurheartj/article/42/47/4791/6362485Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 New trial on Triglyceride lowering1:21 Triglycerides vs Lipoproteins3:55 Conclusion of the trial5:24 LDL particle size6:30 Big picture7:50 Markers vs Makers10:27 Ratios11:36 Value of Triglycerides13:02 Improving health as a whole
Seed Oils and Heart Disease Risk | Kevin Maki, PhD Nutrition Made Simple! 2022-12-12 | Do seeds oils and omega-6 fats affect heart disease risk? A look at the evidence on cardiovascular disease and omega-6, omega-3 and saturated fats.After our recent video on seed oils and inflammation, viewers have been asking about cardiovascular disease. Do omega 6 fats and seed oils affect heart disease and cardiovascular disease?Dr. Kevin Maki is the president of the American National Lipid Association. He has published hundreds of studies on lipid biology, including omega6s, saturated fat and cardiovascular disease.We covered the evidence on omega-6s and CVD, omega 3s and saturated fat and the Minnesota and Sydney trials.Connect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1. Lyon: ahajournals.org/doi/pdf/10.1161/01.cir.99.6.7792. PREDIMED: nejm.org/doi/full/10.1056/nejmoa18003893. CORDIOPREV: www.sciencedirect.com/science/article/pii/S01406736220012224.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011737.pub3/full5.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.114.0102366.sciencedirect.com/science/article/pii/S07351097150469147.jamanetwork.com/journals/jamainternalmedicine/fullarticle/25309028.sciencedirect.com/science/article/pii/S07351097150469149. ahajournals.org/doi/full/10.1161/CIR.000000000000051010.https://apps.who.int/iris/bitstream/handle/10665/246104/9789241565349-eng.pdf11.https://www.sciencedirect.com/science/article/pii/S193328741400344412.https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.118.03890813. REDUCE-IT: nejm.org/doi/full/10.1056/nejmoa181279214. Overview: amjmed.com/action/showPdf?pii=S0002-9343(21)00227-815. JELIS: sciencedirect.com/science/article/abs/pii/S014067360760527316. RESPECT-EPA: acc.org/Latest-in-Cardiology/Clinical-Trials/2022/11/05/03/10/respect-epa17. academic.oup.com/eurheartj/article/42/47/4807/635847818. Minnesota: ahajournals.org/doi/pdf/10.1161/01.ATV.9.1.12919. Minnesota recovered: bmj.com/content/353/bmj.i1246.full.pdf+html20. Sydney: bmj.com/content/346/bmj.e8707Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Seed oils & Heart Disease with Dr. Maki1:23 Fat types and Heart Disease6:45 Serum biomarkers9:45 Conclusion10:10 Omega-3s12:43 Minnesota & Sydney16:32 Sydney & trans fats18:00 Future clinical trials
Dr. Michael Greger gets fact-checked by MD PhD doctor (debate) Nutrition Made Simple! 2022-12-05 | Do Dr. Michael Greger´s views on diet and health match the science? A TV debate with Dr. Michael Greger covers heart disease reversal, animal and plant protein, diabetes etc. A critique of Dr. Greger´s claims.We got a ton requests from you to comment on Dr. Michael Greger. This week viewers sent us a new video with dr. Greger, let’s take a lookIt´s a tv show, Greger is in a debate. Greger will argue the vegetarian diet. Reversal of heart disease. Dr. Esselstyn and the Ornish trial. Ornish trial: diet, stopping smoking, stress management (meditation etc), exerciseMany diets “reverse” diabetes, normalize glucose. low fat diets can reverse diabetes, low carb diets can reverse diabetes. elimination diets cut junk food, weight loss improves glucoseovert deficiency of protein or kwashiorkor virtually nonexistent in the west. we can avoid overt deficiency and not be at optimal level. true: main threats are diseases of excess. Heart disease, obesity, diabetes, even cancer: diseases of eating too many calories, too much of the wrong foodsRed meat intake reduced, diabetes went up. People eating more calories and more junk food. red meat not the cause of this rise in diabetes but red meat could raise risk of diabetes. reduction of red meat and even bigger increase of refined carbohydrates, overall more calories, risk of diabetes goes up but in theory both foods could be diabetogenicdoes not imply more diabetes due to less meatConnect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1-academic.oup.com/ajcn/article/108/2/405/5042716?login=true2-link.springer.com/article/10.1007/s12603-019-1174-13-sciencedirect.com/science/article/pii/B97801280396870003564-onlinelibrary.wiley.com/doi/epdf/10.1002/fsn3.18095-mdpi.com/2072-6643/11/11/2661/htm6-link.springer.com/article/10.1007/s40279-021-01434-97-pubmed.ncbi.nlm.nih.gov/335970568-frontiersin.org/articles/10.3389/fnut.2022.934438/full9-nutritionj.biomedcentral.com/articles/10.1186/1475-2891-12-8610-jissn.biomedcentral.com/articles/10.1186/s12970-014-0064-511-pubmed.ncbi.nlm.nih.gov/3317250612-cdn.mdedge.com/files/s3fs-public/Document/September-2017/JFP_06307_Article1.pdf13-1 year: chrisjbradshaw.com/wp-content/uploads/2016/01/Can-lifestyle-changes-reverse-coronary-heart-disease-Ornish-Lancet-1990.pdf5 year: jamanetwork.com/journals/jama/article-abstract/18827414-ahajournals.org/doi/full/10.1161/STROKEAHA.120.03321415-pubmed.ncbi.nlm.nih.gov/2922164516-pubmed.ncbi.nlm.nih.gov/3085213217-sciencedirect.com/science/article/pii/S073510971741232018-sciencedirect.com/science/article/abs/pii/S016882270900433119-Dr. Greger´s content on olive oil:nutritionfacts.org/topics/olive-oilnutritionfacts.org/video/olive-oil-and-artery-functionour content going over the evidence:youtu.be/bN6JJZw3m0Ayoutu.be/Jv4vjHrpaKo20-nature.com/articles/s41591-022-01968-z21-bmj.com/content/371/bmj.m414122-ncbi.nlm.nih.gov/pmc/articles/PMC459307223-bmj.com/content/371/bmj.m414124-scientificamerican.com/article/new-system-ranks-evidence-for-health-risks-of-eating-red-meat-smoking-and-more-but-critics-say-its-overly-simplisticOther videos:Dr. Greger & fish: youtu.be/s7QRLZp63Eoour red meat video: youtu.be/mQ56uOkjccgour fish video: youtu.be/QKfU6dBB764 Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 New video with Dr. Greger1:20 Do Americans get enough protein?5:25 Bioavailability of animal & plant protein6:33 Developing world and animal foods7:49 Polarized Debates9:18 Plant-based diets & supplements10:11 Dr. Greger & reversal of heart disease14:21 Reversing Diabetes16:06 Deficiencies vs excess17:45 The Ornish trial21:34 Red meat and diabetes24:43 Heart disease & insulin resistance26:36 Vegetarian diet and risk of disease29:03 The debate heats up30:22 Ecological data & hierarchy of evidence32:39 Red meat and health risk38:02 Scams, superfoods & ancestor diets39:33 My conclusion of the debate40:18 My views on Dr. Michael Greger41:39 The main lesson from all this!
5 Myths about the Coronary Calcium Score (CAC) | Tom Dayspring, MD Nutrition Made Simple! 2022-11-28 | The Coronary Calcium Score can be useful, but several myths surround it. We cover 5 misconceptions regarding the calcium score and how to interpret a calcium score to lower our heart disease risk.Let’s talk calcium scan or calcium score. The calcium scan shows calcification in coronary arteriesmyth: “CAC score of 0 means no plaque”a CAC score of 0 doesnt mean no plaqueCAC doesnt measure plaque. Measures calcification. Calcification happens late in plaque formation process.you can have a CAC of 0 and have soft plaque. Non calcified.study: people with lots of plaque, 14% had CAC of zero. most young people with obstructive CAD had a CAC of zero“diagnostic value of a CAC score of 0 small in the young"advanced coronary disease: ~30% of heart attacks or death in people with CAC of zeroif CAC is zero odds are low you have obstructive CAD. but doesnt rule it outeven with a lot of plaque, calcification may not have developedCAC =0 is good news, it’s a marker of lower risk, but it doesn´t mean immunitywe can have plaque in other places besides coronariesCAC=0: 54% had plaque in the legs or the carotidsCAC of zero is desirable, but far from perfectCAC=marker of advanced disease. CAC=0 may mean no plaque. or maybe there is. CAC doesnt rule that outCAC=0 doesnt mean zero calcification. just detectable calcification scan picks up calcification above certain size, not small calcium spots. ~4% with CAC=0 had calcification myth: CAC=0 means zero risk"LDLc or apoB is high but CAC=0 so I´m safe"“score of zero does not imply risk is zero (heart attack, stroke etc) or zero atherosclerosis (plaque)”“CAC of zero may provide false sense of security”CAC of zero indicates low 5-10y risk value of CAC score depends on ageCAC=0 is the norm in young“CAC of zero in the young is normal, more power at older age. value of a CAC of zero increases with age”myth: "if CAC goes up, i´ll make changes"calcification=advanced plaquereal power is in preventing plaque“Plaque calcification is a late event, not for pre-plaque detection (goal = prevent plaque)”some methods measure soft plaque. angiography.calcium not the cause of risk. marker of riskThe more plaque, the more likely there’s calcification. calcification isn’t the problem. Calcification is part of the scarring of the artery, can make artery less likely to rupture“plaque disruption and thrombosis not in calcified segments; calcium not the cause”in general more calcium means higher risk, it´s a marker of more plaque and more advanced plaque, but something could increase calcium and not raise riskstatins can increase CAC but risk goes down. statins stabilize plaque, including calcificationCAC can refine risk. young with CAC that is NOT zero; older with a score of zero; borderline case with some risk factors but not clear if statin is appropriate, CAC can help decideConnect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1-One page primer: jamanetwork.com/journals/jamacardiology/fullarticle/27956712-obstructive CAD: jamanetwork.com/journals/jamacardiology/fullarticle/27855863-plaque in other territories even with CAC=0ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.114.0143104-calcification even with CAC=0europepmc.org/articles/pmc9612790/bin/jeab135_supplementary_data.docxatherosclerosis-journal.com/article/S0021-9150(20)30378-6/fulltext5-CAC=0 desirable but imperfectahajournals.org/doi/epub/10.1161/CIRCULATIONAHA.119.0450266-low 10y risk with CAC=0sciencedirect.com/science/article/pii/S2666667722000551?via%3Dihub7-prevalence of CAC=0jamanetwork.com/journals/jamacardiology/fullarticle/26010718-calcium is not the cause: jacc.org/doi/10.1016/j.jacc.2021.12.018Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 What is the calcium score?0:53 Plaque with CAC=03:53 Calcification with CAC=04:32 CAC=0 and Risk8:01 Calcium score and Age9:33 Window of opportunity10:47 More sensitive tests12:17 Calcium is not the cause13:32 Statins and Calcium15:25 Take-aways and strategy16:50 Additional Resources
Fraud & Deception in Science | Elisabeth Bik, PhD Nutrition Made Simple! 2022-11-21 | Science fraud detective Elisabeth Bik explains how she spots scientific misconduct and the incredible aftermath of uncovering fraud in science.Support Dr. Bik on Patreon: Patreon.com/elisabethbikFollow her on Twitter: @MicrobiomDigestHer blog: scienceintegritydigest.com/aboutConnect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1-nytimes.com/interactive/2022/10/29/opinion/science-fraud-image-manipulation-photoshop.html2-journals.asm.org/doi/epub/10.1128/mBio.00809-163- (in French) https://www.francetvinfo.fr/replay-magazine/france-2/complement-d-enquete/complement-d-enquete-du-jeudi-17-novembre-2022_5444497.html4-pubpeer.com/static/extensions5-sciencedirect.com/science/article/pii/S0924857920300996Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Meet a science fraud detective1:38 From plagiarism to image duplications5:29 Spotting scientific fraud8:39 Error & manipulation16:22 Why some scientists commit fraud23:17 Fighting Institutional Inertia and Ego32:09 Fraud factories34:30 The shockwaves of fraud36:44 Preventing fraud39:06 Robust science41:37 Silver Linings
Does Red Yeast Rice work? | Cholesterol-lowering supplements Nutrition Made Simple! 2022-11-14 | Do cholesterol-lowering supplements like red yeast rice and phytosterols work? Are they safe? Little-known aspects of supplements, doses and safety concerns.A new trial compared a statin to several supplements. Rosuvastatin vs phytosterols vs red yeast ricelow dose of statin, 5mg. 1.6mg sterols, 2.4mg red yeast rice.the active ingredients in red yeast rice are called monacolins, the main one being monacolin K.analysis of trials using red yeast rice. lowered LDLcholesterol by 40pts. red yeast rice not significantly different from statinnot all trials report amount of monacolin K in the supplements. effect of supplements varies depending on where we get our bottle. phytosterols: analysis of trials shows phytosterols lowers LDLc by ~8-10% So phytosterols probably do have a cholesterol-lowering effect its just mildQuick caveat regarding phytosterols: some people are sterol hyperabsorbers in the intestine, and for those people, phytosterol supplements are not a good idea. Another option is a stanol, which also lowers cholesterol and doesnt get absorbedcaveat with supplements: safety. Most available data with red yeast rice suggests low side effects. trial for red yeast rice looked at risk.Connect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1-jacc.org/doi/epdf/10.1016/j.jacc.2022.10.0132jamanetwork.com/journals/jamainternalmedicine/fullarticle/2261093-ncbi.nlm.nih.gov/pmc/articles/PMC56134794-sciencedirect.com/science/article/pii/S00219150150022215-link.springer.com/article/10.1186/1749-8546-1-46-sciencedirect.com/science/article/pii/S00219150130048757-agsjournals.onlinelibrary.wiley.com/doi/full/10.1111/j.1532-5415.2007.01230.x8-https://ir.nctu.edu.tw/bitstream/11536/8558/1/000257721400029.pdfacademic.oup.com/eurheartjsupp/article/21/Supplement_B/B71/5422925Position paper: academic.oup.com/nutritionreviews/article/75/9/731/4065280Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 New trial: cholesterol-lowering supplements1:12 Big Pharma funding?2:22 Do supplements work?3:08 Can we trust supplements labels?4:30 Red Yeast Rice6:37 Phytosterols7:51 Safety8:20 Cardiovascular Risk9:44 Legal Battles10:35 My approach to cholesterol-lowering
Low Carb Cardiologist on Saturated Fat, Cholesterol & ApoB | Dr. Ethan Weiss Nutrition Made Simple! 2022-10-31 | Is high cholesterol harmful on a low carb diet? What about saturated fat?Does high HDL-C and low triglycerides eliminate risk? How about a calcium score of zero? Low Carb Cardiologist Dr. Ethan Weiss addresses common low carb FAQs.ApoB & ASCVD risk. you can predict per milligram per deciliter reduction in LDL-cholesterol or apoB you'll see a specific reduction in riskthe simplest answer: what's your ApoB? the role of HDL in atherosclerotic coronary disease is fascinating. triglycerides: it's the apoB component of triglycerides probably that contributes to risk, so the simplest way to think about this is what´s your apoB. statins are not LDL-reducing drugs, or apoB reducing drugs, they're heart attack risk-reducing drugs, they happen to also reduce LDL. high ApoB and a high HDL-cholesterol.calcium scoring. the power of zero is much more impactful in an older person. if you have calcium in your arteries at 20 you got a problem. having zero calcium score after three or four or five years of having hypercholesterolemia or high apoB doesn't necessarily tell us much, you could be growing soft plaque. statins can raise calcium score at the same time as they lower risk. statins increase deposition of calcium but they reduce risk.is it the saturated fat itself or is it the carbs, if I'm on a low carb diet maybe that eliminates the risk? high saturated fat confers high apoB. if your ApoB is still good, from a coronary perspective it's hard for me to go beyond the ApoB. for me it's all driven by ApoB.oxidized or modified LDL or ApoB. drugs to specifically modulate oxidized LDL independent of overall LDL have all failed. if you have less residence time, if your LDL receptors are upregulated, it's less likely to be modified. monoclonal antibodies against oxidized LDL failed. next week: low carb diets to maximize cardiovascular healthSubscribe for more free nutrition and health tips: bit.ly/2toMJ9uConnect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1-pubmed.ncbi.nlm.nih.gov/33870931ahajournals.org/doi/full/10.1161/JAHA.113.000759#d3e9172- sciencedirect.com/science/article/abs/pii/S19332874130024933-jamanetwork.com/journals/jama/article-abstract/27227704-sciencedirect.com/science/article/abs/pii/S00219150193000245-ncbi.nlm.nih.gov/pmc/articles/PMC41035146-europepmc.org/articles/pmc2988224/bin/mmc1.pdf7-jamanetwork.com/journals/jamacardiology/fullarticle/27855868-academic.oup.com/jcem/article/105/12/dgaa674/59091619-sciencedirect.com/science/article/pii/S002191502101416710-https://apps.who.int/iris/bitstream/handle/10665/246104/9789241565349-eng.pdf11-academic.oup.com/jn/article/135/9/2075/4664084?login=false12-jacc.org/doi/full/10.1016/j.jcmg.2014.06.021Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Intro0:52 How Dr. Weiss got into low carb diets2:20 High cholesterol on low carb7:15 HDL-C and triglycerides10:57 Calcium score14:22 Saturated fat on low carb17:07 LDL modification (oxidation etc)
Low Carb vs Fasting. Which is better? | Brand New Trial Nutrition Made Simple! 2022-10-24 | A new trial compares a Low Carb diet to Fasting for weight loss and metabolic improvements. ~50 participants each were asked to eat low carb or fast for 3 months. Which program delivered the largest benefits?Low carb or fasting? Which is better for weight loss and health in general? 150 men and women with Metabolic Syndrome (metabolic disturbance with ≥3 of high glycemia, high blood pressure, low HDL-C, high triglycerides, obesityLooking for weight loss and improvement in metabolic parametersparticipants randomized onto low carb, fasting or bothlow carb: under 130g of carbs a day (26% of calories); very low carb: 20-50g or under 10%. fasting: participants chose early TRE or late TREBody weight reduced on all 3 groups for the 1st 2 months. during 3rd month, only combo group continued to lose weight, the other 2 plateaued after 3 months combo group had lost the most. fasting TRE lost more than low carbindicators of fat loss: waist circumference, hip circumference, body fat. all 3 groups reduced those. waist to hip ratio (indicator of abdominal obesity) lower on fasting group, outperformed even combohealth is about a lot more than just weight loss. types of fat. subcutaneous fat vs visceral fat inside body cavity around and inside the organs. All 3 groups lost subcutaneous fat but only the 2 fasting groups lost visceral fat. not low carb aloneother metabolic parameters beyond weight and fat: glucose, lipids or blood pressure. Glucose was surprising. Only the 2 fasting groups improved fasting blood glucose. Low carb alone did not. Uric acid was similar, only the 2 fasting groups saw an improvement. HbA1c, glycated Hb, only combo group saw an improvement. all groups saw a reduction in fasting insulin and insulin resistance.Only the 2 fasting groups lowered triglycerides and only the combo raised HDL-cLDL-c was raised on low carb.“low carb” definition. low carb group ate less than half the carbs of the fasting group. reduced rice, flour, whole grains, potatoes, refined carbs average carb intake 140-150g/d. so not low carb diet, maybe moderate carb diet Not specific to low carb, we see this in low fat trials too.ketosis, in very low carb settings. trial compared ketogenic diet to a low carb but not ketogenic diet matched for calories. 5 and 15% calories from carb respectively. ketones can help suppress appetiteSubscribe for more free nutrition and health tips: bit.ly/2toMJ9uConnect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1-cell.com/cell-reports-medicine/fulltext/S2666-3791(22)00332-92-sciencedirect.com/science/article/pii/S08999007140033233-sciencedirect.com/science/article/abs/pii/S02615614210011634-lipidjournal.com/article/S1933-2874(19)30267-3/fulltextDisclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 New trial compares Low Carb vs Fasting3:48 Weight Loss5:45 Types of fat6:52 Lipids, Glucose, Insulin9:02 What does it mean11:45 Was it "low carb"?13:24 A key threshold for carbs?
Are Seed Oils Inflammatory?! (The *Evidence* No One Shows) Nutrition Made Simple! 2022-10-17 | "Seed oils are inflammatory!" according to every blog and podcast. But what does the science say? The evidence on 9 different seed oils, heated seed oils and genetic variability. A complete look at seed oils & inflammation and all the evidence you were never shown.Are seed oils inflammatory?1. seed oil on inflammation2. Heated seed oilvegetable oil is inflammatory? Only seed oils are inflammatory? Depends on omega6s, Linoleic acid?flaxseed oil not inflammatory. omega3 rich, can be anti-inflammatorycanola oil: CRP didn't changesaturated fat vs omega 6s. replaced saturated fat with unsaturated fats (canola and sunflower). no change in inflammatory markers one trial compared canola to olive oil, found a reduction in CRP on both canola and olive oilsimilar to flaxseed oil. anti-inflammatory?~1tbsp sunflower oil daily. refined oil, treated with chemicals and heated, not cold-pressed. no significant change to CRP“n-6 PUFA may act as anti-inflammatory”Connect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:mdpi.com/2072-6643/8/3/136/htmsciencedirect.com/science/article/abs/pii/S2405457720302047link.springer.com/article/10.1007/s00394-007-0668-5ncbi.nlm.nih.gov/pmc/articles/PMC4050683pubmed.ncbi.nlm.nih.gov/27737722ncbi.nlm.nih.gov/pmc/articles/PMC6405399/pdf/40200_2018_Article_343.pdfsciencedirect.com/science/article/abs/pii/S0939475320302349sciencedirect.com/science/article/pii/S0278691513008612nature.com/articles/s41430-019-0438-5academic.oup.com/ajcn/article/95/5/1003/4576714pubs.rsc.org/en/content/articlehtml/2017/fo/c7fo00433hacademic.oup.com/eurjpc/article/20/2/202/5927989ncbi.nlm.nih.gov/labs/pmc/articles/PMC5587404pubmed.ncbi.nlm.nih.gov/16351767academic.oup.com/jn/article/141/12/2166/4689010reader.elsevier.com/reader/sd/pii/S0899900721002057academic.oup.com/jn/article/148/10/1556/5094775pubmed.ncbi.nlm.nih.gov/19234585lipidworld.biomedcentral.com/articles/10.1186/1476-511X-13-196tandfonline.com/doi/abs/10.1080/07315724.2008.10719674pubmed.ncbi.nlm.nih.gov/23506314sciencedirect.com/science/article/pii/S0021915002004276link.springer.com/article/10.1007/BF00262088sciencedirect.com/science/article/pii/S0021915004000711ncbi.nlm.nih.gov/pmc/articles/PMC3115398/pdf/nihms271497.pdflink.springer.com/article/10.1007/s00394-007-0668-5pubs.rsc.org/en/content/articlehtml/2017/fo/c7fo00433hthieme-connect.com/products/ejournals/html/10.1055/s-0037-1615680academic.oup.com/ajcn/article/112/1/150/5727348sciencedirect.com/science/article/abs/pii/S0021915019315758onlinelibrary.wiley.com/doi/pdf/10.1002/mnfr.201400446academic.oup.com/ajcn/article/89/1/248/4598248sciencedirect.com/science/article/abs/pii/S0939475310002978sciencedirect.com/science/article/abs/pii/S1043466619303515pubs.rsc.org/en/content/articlelanding/2020/fo/d0fo00875c/unauthsciencedirect.com/science/article/pii/S0019483215008299tandfonline.com/doi/abs/10.1080/07315724.2011.10719940sciencedirect.com/science/article/pii/S0271531707000899onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.201100533academic.oup.com/advances/article/9/6/688/5090303ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.108.191627pubmed.ncbi.nlm.nih.gov/21663641ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.114.012534academic.oup.com/ajcn/article/109/1/165/5280796?login=falseDisclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Are seed oils inflammatory? Intro1:36 Schools of thought2:06 Flaxseed Oil3:35 Science, Variability & Perception6:00 Canola Oil8:02 Sunflower Seed Oil10:36 Sesame Oil11:14 Soybean Oil12:52 Corn Oil14:00 Hempseed and Grapeseed Oil14:31 Safflower Oil15:42 Dose16:52 Time18:36 Acute changes in gene expression19:45 Whole sources of fat20:33 Heated Seed Oils24:51 Summary25:38 Seed Oil vs Junk Food26:03 Funding28:01 Biochemical mechanisms30:42 Genetic variation31:28 Dietary choices and emotion
Debunking the TOP 3 Weight Loss MYTHS Nutrition Made Simple! 2022-10-10 | Is my weight genetically determined or can I change it? Do I need to lose a LOT of weight to experience benefits? Should I focus on weight loss or weight maintenance? TOP 3 weight loss myths debunked3 common myths that complicate weight loss.Most people focus on their end goal. I want to lose 20lbs. I want to lose 100lbs.large weight losses are popular but even small weight loss can deliver a lot of health benefits. improving glucose metabolism and ttriglycerides, mood, mobility, pain relief and mortality risk So even a modest weight loss achievable in a couple weeks delivers significant benefits.Diabetic patients on weight loss diets can normalize blood glucose levels after 8 days. plenty to look forward to at that early stage of weight loss"If only I can lose this weight, then my work is done". losing weight is the easy part. common to see weight loss in many studies. cutting back on ultraprocessed stuff brings down weight. but after initial drop, weight loss stops or even bounces back. yo-yo, lose weight but put it back on. when we lose weight our body starts using less energy. energy needed to keep the body running at rest goes down with weight loss. "I ate the same but I stopped losing weight so calories dont matter"focusing less on weight loss itself and more on the key habits.are we genetically set for a certain weight? physiological resistance to weight loss, body works against us when it comes to losing weight and “helps” when it comes to regaining weightFinding a satiating diet without going overboard on calories. Carbs? Fat? cutting carbs or fat is about equally effective for weight loss calorie for calorie. vegan diets & animal keto diets can all work for weight loss, but junk food induces overeatinglow carb junk or low fat junk: if it´s calorically concentrated it’s going to push you to overconsumelow calorie soda helps with weight loss When we lose weight our body produces less satiety hormones and more hunger hormones so we’re hungrier. calories vs hormones. they work together. finding healthier meals & healthier snacks that fill us up with less calories.people with more intense brain responses to food pictures are at higher risk of weight gainpeople who are sleep deprived for only 5 days can gain 2lbs, mainly by eating more and more caloric foodsConnect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences: 1-sciencedirect.com/science/article/pii/S26673681220000922-link.springer.com/article/10.1007/s00125-011-2204-73-jamanetwork.com/journals/jama/fullarticle/1816054-academic.oup.com/ajcn/article-abstract/49/1/93/47162825-sciencedirect.com/science/article/pii/S26673681220002506-pubmed.ncbi.nlm.nih.gov/296770137-tandfonline.com/doi/full/10.1080/07315724.2020.1869625link.springer.com/article/10.1007/s11892-018-1103-48-cell.com/cell-metabolism/fulltext/S1550-4131(19)30248-79-onlinelibrary.wiley.com/doi/pdfdirect/10.1111/obr.1302010-academic.oup.com/jcem/article/83/1/214/2865196nejm.org/doi/full/10.1056/nejmoa01290811-pubmed.ncbi.nlm.nih.gov/2251431612-pnas.org/doi/abs/10.1073/pnas.1216951110Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Weight loss Myths0:39 Even modest weight loss has large benefits2:12 Weight loss vs weight maintenance4:11 Is there a "set point" for body weight?4:50 Key factors for weight loss: nutrition7:48 Weight Loss and the Brain8:35 The role of Sleep9:07 Life "hacks"
The Truth about Saturated Fat | New Narrative Review Nutrition Made Simple! 2022-10-03 | A new Review proposes Saturated Fat is harmless and unfairly demonized. Does this reflect the scientific evidence? A look at the science of saturated fat, safe ranges and controversies.Saturated fat: villain and bogeyman in cardiovascular disease? Saturated fat is an emotional topic. Saturated fat raises cardiovascular disease if it's too high.Saturated fat isn’t bad. Health-promoting foods have Saturated fat. Replacing Saturated fat replaced with refined carbs doesn't help. Whole grains lower risk. Unsaturated fats also. PUFA, the lowest. Source of saturated fat matters. fish has saturated fat but also PUFAs. Dark chocolate is high in Saturated fat but its stearic acid which. we see benefit of saturated fat moderation in RCTs, usually PUFA is best. MUFA or carb, less consistent.UK Biobank: no evidence that saturated fat intake was associated with CVD, cardiovascular disease. Replacing saturated fat with MUFA or protein was associated with lower risk of death and CVD.Replacing saturated fat with starch or sugar (refined carbs) was associated with lower total death.PUFAs can come in fatty fish, nuts, seeds, vegetable oil, or in junk foods that contain PUFA oils. Saturated fat was associated with lower ischemic heart disease.saturated fat replaced with PUFA benefits CVD. PUFA consumption in place of saturated fat would reduce CHD.Linoleic acid replacing saturated fat associated with lower CHD and. Replacing saturated fat with polyunsaturated fat prevents CHDConnect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:1-academic.oup.com/eurjpc/advance-article-abstract/doi/10.1093/eurjpc/zwac194/66918212-2015 edition: pubmed.ncbi.nlm.nih.gov/260689592020 edition: cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011737.pub3/full3-sciencedirect.com/science/article/pii/S07351097150469144-ahajournals.org/doi/full/10.1161/CIR.00000000000005105-academic.oup.com/ajcn/article/91/3/535/4597110%206-acpjournals.org/doi/abs/10.7326/m13-17887-www.lipidjournal.com/article/S1933-2874(09)00332-8/abstractlipidjournal.com/article/S1933-2874(21)00248-8/fulltext8-mdpi.com/2227-9032/5/2/29/htm9-ahajournals.org/doi/full/10.1161/JAHA.120.01981410-lipidjournal.com/article/S1933-2874(21)00248-8/fulltext11-sciencedirect.com/science/article/abs/pii/S014067361732252312-bmj.com/content/368/bmj.m68813-mdpi.com/2072-6643/14/17/3603/htm14-academic.oup.com/ajcn/article/103/2/356/456475415-nejm.org/doi/full/10.1056/nejmoa180038916-pubmed.ncbi.nlm.nih.gov/2951101917-pubmed.ncbi.nlm.nih.gov/2754347218-pubmed.ncbi.nlm.nih.gov/2516104519-journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.100025220-pubmed.ncbi.nlm.nih.gov/2812580221-pubmed.ncbi.nlm.nih.gov/2674617822-bmj.com/content/346/bmj.e870723-bmj.com/content/353/bmj.i124624-pubmed.ncbi.nlm.nih.gov/2852602525-bmj.com/content/351/bmj.h3978.long26-foodandnutritionresearch.net/index.php/fnr/article/view/68027-nmcd-journal.com/article/S0939-4753(17)30237-5/fulltext28-pubmed.ncbi.nlm.nih.gov/3230719729-clinicalnutritionjournal.com/article/S0261-5614(20)30355-1/fulltext30-jacc.org/doi/abs/10.1016/j.jacc.2020.05.07731-lipidjournal.com/article/S1933-2874(21)00248-8/fulltext32-link.springer.com/article/10.1007/BF0253585633-food-guide.canada.ca/en/guidelinesDisclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 New Review0:47 Dose2:49 Replacement6:42 Source8:10 Standing questions9:25 Rationale10:00 Epidemiology21:36 RCTs23:05 Meta-analyses etc28:08 The final analysis32:35 Conclusion of the Review34:03 Skepticism34:54 Anatomy of Confusion36:40 Scientific communication38:24 The cycle of social media40:21 Evolution41:34 Saturated Fat: harmful or neutral?42:10 Take-home message
The effect of dietary cholesterol on blood cholesterol & individual variability | Dr. Tom Dayspring Nutrition Made Simple! 2022-09-26 | Does eating cholesterol raise our blood cholesterol levels? Why does this vary from person to person? How can you test where YOU fall on the spectrum? All your questions on dietary cholesterol answered.The usual extremes, “cholesterol is poison everyone should eat zero cholesterol" vs “cholesterol is always harmless”. We cover cholesterol absorption in the intestine, the effect on serum cholesterol, tests of absorption status, and actionable advice to lower risk.Subscribe for more free nutrition and health tips: bit.ly/2toMJ9uConnect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:link.springer.com/chapter/10.1007/978-3-030-56514-5_13sciencedirect.com/science/article/pii/S0022227520401099ncbi.nlm.nih.gov/pmc/articles/PMC3965667nejm.org/doi/full/10.1056/NEJMoa1405386https://boris.unibe.ch/64847/1/NEJMc1500124.pdfacademic.oup.com/eurheartj/article/41/28/2618/5875424academic.oup.com/ajcn/article/109/1/7/5266898onlinelibrary.wiley.com/doi/abs/10.1111/jfbc.13263gastrojournal.org/article/S0016-5085(04)02028-1/fulltextDisclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Introduction2:09 How the body regulates cholesterol levels3:28 Intestinal absorption6:17 Esterified vs free cholesterol13:14 The Niemann-Pick, an intestinal cholesterol gateway16:46 Individual variability20:10 What happens to cholesterol after absorption30:18 The microbiome & cholesterol31:58 Phytosterols & other supplements35:48 Testing your cholesterol absorption40:27 Pharmacological Management 43:45 Recap
Health effects of eating fish and safety concerns (mercury, PCBs, dioxins) Nutrition Made Simple! 2022-09-19 | Is fish health-promoting or toxic? Is it better to avoid fish and eat only plants? What about contaminants like mercury, PCBs or dioxins?Connect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:10 vegan myths full video:youtube.com/watch?v=e8Vf9Aixn5Asciencedirect.com/science/article/abs/pii/S0924224419310532academic.oup.com/ajcn/article/105/6/1462/4569801?login=falsejamanetwork.com/journals/jamainternalmedicine/fullarticle/2540540academic.oup.com/ije/article/50/1/223/6067620?login=falsenature.com/articles/s41430-018-0310-zjamanetwork.com/journals/jama/fullarticle/203640Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Introduction0:50 Is eating fish unhealthy?2:30 Are plants more health-promoting than fish?3:48 Vegans vs Pescaterians4:55 Reconciling environmental concerns and health data6:30 What about the saturated fat?6:41 Contaminants (mercury, PCBs, dioxins)
Statins & Diabetes. A Step-by-Step Guide Nutrition Made Simple! 2022-09-12 | Do Statins cause Diabetes? What factors determine diabetes risk on a statin and how can we avoid it? A step-by-step guide to statin use and diabetes riskPart II of the statin series focuses on diabetes.In some trials statins raise risk of diabetes, in others statins have no significant effect, in others statins lower risk of diabetes.some meta-analyses find statins raise risk of diabetes, others find no significant effect of statins on risk of diabetes.risk of diabetes on a statin are determined by diabetes risk factors, statin dose and statin type. people with risk factors for diabetes (obesity, Metabolic syndrome, pre diabetes; fasting glucose or glycated hemoglobin above normal but not in diabetic range), statins reduce cardiovascular risk (heart attacks, strokes) but increase risk of diabetes. For people without diabetes risk factors, statin reduces cardiovascular outcomes with no significant increase in diabetes riskrisk of diabetes on a statin mainly a concern for people already at risk of diabetes; both with and without diabetes risk factors the benefits of the statin outweigh the risks“cardiovascular and mortality benefits of statin exceed diabetes hazard, including among those at higher risk for developing diabetes”absolute terms: 2 cardiovascular events avoided per new case of diabetes, in people at higher risk of diabetesSome statins raise diabetes risk, some don't. e.g. Pravastatin and pitavastatintalking to a cardiologist I would factor in diabetes risk factors, consider lower dose or a statin that doesn´t raise risk and follow fasting glucose and HbA1c, glycated hemoglobinwhy do some statins raise risk of diabetes? they may raise BMI which raises insulin resistance & diabetes. maintaining healthy body weight via diet and exercise while on a statin may lower riskSometimes people claim statins double risk of diabetes based on observational studies. when adjusted, the effect is cut in half and fasting blood glucose becomes non significant. Also, the effect differed by statin type, it was strongest with atorvastatin and not significant with most other statins like pravastatin or pitavastatinmost long observational studies show a diabetes risk of atorvastatin and rosuvastatin, while pravastatin and pitavastatin show no significant effectbased on this, I would assess diabetes risk factors, obesity, pre-diabetes, i´d lean toward statins that don´t increase risk, e.g. pravastatin or pitavastatin, If we need atorvastatin or rosuvastatin, i´d favor moderate dose. If it doesnt bring cholesterol down enough, i´d rather add ezetimibe or pcsk9 inhibitors rather than crank up statin dose. and keep an eye on glycemia and keep lifestyle healthyConnect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences: nejm.org/doi/full/10.1056/NEJMoa0807646diabetesjournals.org/care/article/26/10/2713/26138/Secondary-Prevention-of-Cardiovascular-Events-Withahajournals.org/doi/full/10.1161/01.CIR.103.3.357onlinelibrary.wiley.com/doi/pdf/10.1002/pds.4020http://plaza.umin.ac.jp/~juku-PT/pharmacother/lancet2010.pdfbmj.com/content/bmj/374/bmj.n1537.full.pdfjamanetwork.com/journals/jama/fullarticle/2795522ncbi.nlm.nih.gov/pmc/articles/PMC3774022ncbi.nlm.nih.gov/pmc/articles/PMC6047411/pdf/ehy182.pdfsciencedirect.com/science/article/abs/pii/S0140673616313575jamanetwork.com/journals/jama/article-abstract/646699thelancet.com/journals/lancet/article/PIIS0140-6736(22)00916-3/fulltextahajournals.org/doi/epdf/10.1161/CIRCULATIONAHA.122.061620sciencedirect.com/science/article/abs/pii/S0021915015013519care.diabetesjournals.org/content/early/2021/11/16/dc21-1284.abstractlink.springer.com/article/10.1007/s00125-015-3528-5cardiab.biomedcentral.com/articles/10.1186/s12933-022-01524-6academic.oup.com/eurheartj/article/37/11/908/2398344Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Introduction0:52 Disclaimer1:20 The setup3:12 Statins & Diabetes risk5:24 Diabetes risk factors10:39 Statin dose12:53 Statin types15:24 Putting them together16:46 Mechanisms17:20 Observational evidence20:08 Funding20:52 Summary22:24 Importance of information quality
Can a Vegan diet REVERSE Heart Disease?! Nutrition Made Simple! 2022-09-05 | It´s often claimed a vegan diet reverses heart disease. A bold claim, but is it accurate? Did Drs. Ornish and Esselstyn prove a vegan diet reverses heart disease?Subscribe for more free nutrition and health tips: bit.ly/2toMJ9uConnect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:sciencedirect.com/science/article/abs/pii/014067369091656Ucdn.mdedge.com/files/s3fs-public/Document/September-2017/JFP_06307_Article1.pdfacpjournals.org/doi/10.7326/0003-4819-121-5-199409010-00007ahajournals.org/doi/10.1161/circulationaha.108.773747ahajournals.org/doi/full/10.1161/STROKEAHA.120.033214sciencedirect.com/science/article/abs/pii/S0140673622001222Full 1h30min video: www.youtube.com/watch?v=e8Vf9Aixn5ADisclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Introduction1:08 The Esselstyn report3:21 The Ornish trial7:29 Mediterranean diet & Plaque reversal9:39 The bottom line
Saturated fat & Controversies Online | ft. Dr Brad Stanfield Nutrition Made Simple! 2022-08-29 | Why does saturated fat appear so controversial on the internet? Does this reflect the science on saturated fat? Do saturated fat recommendations differ from country to country?Connect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011737.pub3/fulllipidjournal.com/article/S1933-2874(21)00248-8/fulltextDisclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Introduction0:33 Saturated Fat & science communication3:19 Controversial topics7:09 Information sources8:54 Cultivating Healthy Skepticism
Everything you need to know about Lp(a) | ft. Dr. Tom Dayspring Nutrition Made Simple! 2022-08-22 | Lipoprotein(a) or Lp(a) raises risk of heart disease in 1 out of 5 people, yet few have heard of it. We cover all you need to know about Lp(a). Today we take a look at lp(a). Dr. Tom Dayspring goes over what is lp(a) and why it raises cardiovascular risk.Cholesterol travels in lipoproteins. LDL and HDL. low density lipoprotein and HDL high density lipoprotein LDLs carry ApoB, a protein that wraps around the LDL. we can measure ApoB, it equals number of lipoproteins in that familyWe can measure the content of lipoproteins, lipid panel contains LDL-cholesterol=how much cholesterol is carried in LDL lipoproteinslp(a) is a type of LDL. lp(a) is an exception. most ApoB-carrying lipoproteins are equally atherogenic. Small LDLs, large LDLs, VLDLs. lp(a) is an outliermost of us have low lp(a). genetically determined. ~20% have high lp(a)tests of lp(a). we can measure number of lp(a) lipoproteins (nmol/L) or mass (in mg/dL)Everyone should measure lp(a) once. lp(a) raises cardiovascular riskhigh lp(a): managing other risk factors: healthy diet, physical activity, body weight, not smoking, blood pressure, diabetes and apoB 70% lower risk in people with high lp(a) when lifestyle and risk factors under controlstatins dont lower lp(a) but statins lower risk in people with high lp(a)PCSK9 inhibitors lower lp(a) by 25-30% New meds in development. Reduce lp(a) by 80% saturated fat lowers lp(a) but raises ApoB. other studies show reduction of lp(a) on lower saturated fat dietsTrans fats increase lp(a) but most are banned from the market in the USno diet demonstrated for lp(a) specifically but diet can help with risk factors like ApoB and BPSummary: measure lp(a) onceReferences:jamanetwork.com/journals/jama/article-abstract/2790914pubmed.ncbi.nlm.nih.gov/31147269sciencedirect.com/science/article/pii/S0021915016314782academic.oup.com/eurheartj/article/34/13/982/484905atherosclerosis-journal.com/article/S0021-9150(22)00183-6/fulltextsciencedirect.com/science/article/abs/pii/S002604951100240Xncbi.nlm.nih.gov/pmc/articles/PMC6489854Peter Attia´s podcast: www.youtube.com/watch?v=4H0mVPKsGG8Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Introduction1:51 Overview. Lipoproteins & lp(a)3:10 What is lp(a)4:26 lp(a) raises cardiovascular risk6:41 How to measure lp(a)11:17 Other risks12:45 Management20:02 Nutrition21:40 Summary and resources
NEW Intermittent Fasting trial: Calories & Autophagy Nutrition Made Simple! 2022-08-15 | A new Intermittent Fasting study shows more weight loss but the role of calories in Intermittent Fasting remains mysterious. We also take a look at autophagy in the context of Intermittent Fasting. New Intermittent Fasting study. Intermittent Fasting=restricting eating to specific time windows. 16:8=eating in 8h window, fasting for remaining 16hfasting involves 2 factors. Not eating for blocks of time can help reduce total calories if we dont completely compensate during the eating windows. and depending what time of day we eat there may be a circadian effect so that eating the same food at different times may have a different physiological impact. eating earlier in the day seems physiologically better than eating laternew trial looks at 16:8 earlier in the day1) does eating earlier in the day without cutting calories have a benefit?2) Does 16:8 give you additional benefit on top of cutting calories? New trial looked at 16:8 on top of restricting caloriesvolunteers restricted calories (500 calories less) and half ate their food only during an 8h window early in the day, the other half ate in a wider window. the goal was to have them eat same foods, same calories, just eaten at different timesBoth groups lost weight (both cut calories). the group on 16:8 lost more.Does that mean fasting wins? we can lose weight by losing muscle. or fat. both groups lost fat. 16:8 completers lost more fat. \Does 16:8 deliver other benefits beyond weight loss? 16:8 also lowered diastolic blood pressure and improved mood. 41% of 16:8 completers plan to continue with 16:8 early in the dayauthors suspect 16:8 reduced energy intake more. stronger caloric deficit on 16:8?additional benefits due to eating less calories? are there extra benefits of circadian effect we can’t get just by controlling calories?previous study on intermittent fasting, also 16:8 + calorie restriction, no added benefit of 16:8. 16:8 might have an effect in some contexts.Headlines: 16:8 protocol provides no benefit vs 16:8 bolster weight lossbigger weight loss may have masked effect of 16:8? contrast between eating window of control group and 16:8 group?If true, eating in 10h window vs 8 may not provide much benefit16:8 or any type of fasting can help restrict calories. there may be a circadian effect on top. TBDWhat about autophagy? Even when we talk about autophagy, viewers want more on autophagy. Let´s talk autophagywhat’s autophagy? autophagy is removal of damaged components in the cell. like the housekeeping and renovation of the cellin mice the benefits of fasting depend on autophagy, when you inhibit autophagy, the benefits are lost. does that mean everybody should fast because of autophagy?several things activate autophagy. Fasting, Exercise, eating less calories, oxidative stress. so its not exclusive to fastingnot as simple as autophagy=good. autophagy is thought to play many beneficial roles but In some diseases autophagy may have both beneficial & harmful effects. so roles of autophagy not entirely clearwe should focus on health benefits whether they work thought autophagy or notFasting is a valid way to control calories. eating earlier may or may not have additional circadian effect independent from caloriesWhether fast or do 16:8 or not, key is food quality and total caloriesWhatever helps you achieve that. fasting or not. 16:8 or notConnect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:jamanetwork.com/journals/jamainternalmedicine/fullarticle/2794819jamanetwork.com/journals/jamainternalmedicine/fullarticle/2794822edhub.ama-assn.org/jn-learning/audio-player/18714204nejm.org/doi/full/10.1056/NEJMoa2114833tandfonline.com/doi/full/10.4161/auto.21327sciencedirect.com/science/article/pii/S1568163718301478?mdpi.com/1422-0067/21/9/3289/htmsciencedirect.com/science/article/pii/S0092867407016856aacrjournals.org/cancerres/article/66/19/9349/526257/Autophagy-in-Cancer-Good-Bad-or-BothDisclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Intermittent Fasting and 16:81:26 The new trial. Results and implications5:39 Context of previous findings8:26 Summary8:42 Autophagy11:41 The Bottomline
Are artificial sweeteners safe? Nutrition Made Simple! 2022-08-08 | Do artificial sweeteners help us cut calories and lose weight? Are they safe? A look at Splenda, Sweet´n Low, Equal, Stevia and other artificial, low-calorie or no-calorie sweeteners. Are they healthier than regular sugar? Are they more effective? Is one brand better?A new study looked at health consequences of consuming artificial sweeteners.They focused on soda which is the #1 source of added sugars in many western countries. Prior studies found people who consume more diet soda tend to have higher risk of weight gain, diabetes, cardiovascular disease, even risk of dying.This doesn’t tell us if drinking diet soda causes these problems. People most likely to consume a lot of diet soda are the ones worried about their weight, who are already obese, with a history of struggling with weight.The new analysis tries to increase chance of looking at actual effect of diet soda on health.Looked diet soda vs regular soda, water vs regular soda and diet soda vs water.Diet soda outperformed regular soda. Lower body weight, BMI, risk of deathWater outperformed regular soda. Lower body weight, body fat, BMI, risk of diabeteswater vs diet soda, they didn’t find any significant differences in body weight, BMI, diabetes, strokemeta of RCTs found sweetners helped reduce weight/BMI compared to regular sugar. one found sweetners reduced energy intake compared to regular sucrose and reduced BMIDo they raise glucose or cholesterol?In that same trial there was no significant effect of sweetners on HbA1c, insulin resistance, cholesterol or triglyceridesanother one looked at stevia. it reduced diastolic blood pressure and fasting glucose. no significant effect on blood lipids, cholesterol and triglyceridesone looked at saccharin (Sweet n low). no effect on glucose metabolism. glucose and insulin response to a meal unchangedone saw no effect of sweeteners on triglycerides or cholesterol; In ppl with normal LDL-cholesterol, small increasesucralose (Splenda): no change in fasting glucose, HbA1c, insulin, triglycerides and cholesterol. postprandial glucose and insulin a little higheroverall sweeteners help with weight loss compared to sugarartificial sweetners are extremely sweet, hundreds of times sweeter than sugar. aspartame is 200x sweeter than sugar and Sucralose in Splenda is 600 times sweeter than regular sugar. Stevia is intermediate, 200-400x sweeter1 study: artificial sweeteners, especially aspartame and acesulfame-K, associated with cancerstudy: changes in microbiome of mice taking artificial sweeteners. saccharin in humans changed microbiome. larger trial: saccharin did not change microbiomeif sweetners help cut back on sugar, data indicates Sweeteners trump sugar. cut back on artificial sweetners? avoid relapse to sugar. better off with artificial sweetnerConnect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:diabetesjournals.org/care/article/45/8/1917/147303onlinelibrary.wiley.com/doi/pdfdirect/10.1111/obr.13020link.springer.com/article/10.1186/1741-7015-9-123nature.com/articles/s41366-020-00704-2academic.oup.com/eurjpc/article/22/12/1575/5926348microbiomejournal.biomedcentral.com/articles/10.1186/s40168-020-00976-w mdpi.com/2076-2607/10/2/434/htmjournals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.0040005fda.gov/food/food-additives-petitions/additional-information-about-high-intensity-sweeteners-permitted-use-food-united-statesnhs.uk/conditions/phenylketonuriapubmed.ncbi.nlm.nih.gov/23909813journals.plos.org/Plosmedicine/article?id=10.1371/journal.pmed.1003950sciencedirect.com/science/article/abs/pii/S027869151300495Xnature.com/articles/nature13793microbiomejournal.biomedcentral.com/articles/10.1186/s40168-020-00976-wmdpi.com/2076-2607/10/2/434/htmDisclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho0:00 Introduction0:44 Prior concerns with Artificial Sweeteners2:34 New study3:53 Uncertainty in science4:32 Randomized trials7:34 Funding10:49 Animal data11:35 Specific conditions11:58 Artificial Sweeteners & Cancer12:42 Artificial Sweeteners & the microbiome14:02 The bottomline16:17 Practical strategies
Fiber Intolerance: Causes & Solutions Nutrition Made Simple! 2022-08-01 | Why do some people thrive on high fiber while others experience intolerance, bloating, pain and other devastating symptoms? A recent clinical trial may finally shed light on the cause and point to strategies to reverse the issue.Connect with Prof. Jacka:https://www.deakin.edu.au/about-deakin/people/felice-jackahttps://foodandmoodcentre.com.au/team/felice-jacka/twitter.com/FeliceJackainstagram.com/proffelicejacka/?hl=enConnect with me:Facebook: facebook.com/DrGilCarvalhoTwitter: twitter.com/NutritionMadeS3Animations: Even Topland @toplandmediaReferences:mdpi.com/2072-6643/12/3/859cell.com/cell/fulltext/S0092-8674(16)30592-Xtranslational-medicine.biomedcentral.com/articles/10.1186/s12967-017-1175-ynature.com/articles/nature11234sciencedirect.com/science/article/abs/pii/S1043276016000357frontiersin.org/articles/10.3389/fimmu.2017.00548/fullsciencedirect.com/science/article/abs/pii/S0092867421007546onlinelibrary.wiley.com/doi/full/10.1111/jgh.13688onlinelibrary.wiley.com/doi/full/10.1111/jgh.13686https://www.mcri.edu.au/news-stories/researchers-discover-immune-system-changes-support-peanut-allergy-remission-childrenonlinelibrary.wiley.com/doi/10.1111/all.15324Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.#NutritionMadeSimple #GilCarvalho #FeliceJacka #FiberIntolerance0:00 Introduction1:09 The microbiome & fiber2:00 Microbiome Diversity3:19 Fermented foods vs fiber6:00 Low FODMAP diets8:08 Re-introduction and desensitization
