Uploaded January 2026 | Updated September 2026, 2 weeks ago
Welcome to another compelling episode of #ExpertTalk by EverythingALS.
In this session, we are joined by Dr. Stephen J. Kolb, Director of the ALS and Motor Neuron Disease Multidisciplinary Clinic and Research Program at The Ohio State University Wexner Medical Center, and Professor of Neurology and Biological Chemistry and Pharmacology at Ohio State.
Dr. Kolb shares insights from the front lines of ALS research and clinical care, focusing on how advances in molecular biology and gene therapy are shaping the future of treatment for people living with ALS. Drawing from both his laboratory and clinical experience, he explores how understanding the genetic and cellular mechanisms of motor neuron disease is opening new pathways for targeted therapies.
This talk highlights the evolving role of precision medicine in ALS, the importance of patient-derived models, and the challenges and opportunities involved in translating research discoveries into real-world clinical care.
In this talk, we cover:
• How molecular and genetic research is advancing our understanding of ALS
• The role of patient-derived models in studying motor neuron disease
• Progress and challenges in developing targeted gene therapies
• What it takes to move discoveries from the lab to the clinic
• How clinical trials are shaping the future of ALS treatment
This session offers a powerful look at how science, medicine, and patient-centered research come together to drive innovation and hope in the ALS community.
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#ExpertTalk #EverythingALS #ALSResearch #GeneTherapy #PrecisionMedicine #ALSCommunity #MotorNeuronDisease #ALSScience #ALSAdvocacy #ALSAwareness #ALSUpdates #ALSExperts #CollaborativeScience
🔔 If you are passionate about advancing ALS research and understanding, like, subscribe, and turn on notifications.
Sharing this episode helps expand awareness and keeps important scientific conversations moving forward.
Welcome to another compelling episode of #ExpertTalk by EverythingALS.
In this session, we are joined by Dr. Stephen J. Kolb, Director of the ALS and Motor Neuron Disease Multidisciplinary Clinic and Research Program at The Ohio State University Wexner Medical Center, and Professor of Neurology and Biological Chemistry and Pharmacology at Ohio State.
Dr. Kolb shares insights from the front lines of ALS research and clinical care, focusing on how advances in molecular biology and gene therapy are shaping the future of treatment for people living with ALS. Drawing from both his laboratory and clinical experience, he explores how understanding the genetic and cellular mechanisms of motor neuron disease is opening new pathways for targeted therapies.
This talk highlights the evolving role of precision medicine in ALS, the importance of patient-derived models, and the challenges and opportunities involved in translating research discoveries into real-world clinical care.
In this talk, we cover:
• How molecular and genetic research is advancing our understanding of ALS
• The role of patient-derived models in studying motor neuron disease
• Progress and challenges in developing targeted gene therapies
• What it takes to move discoveries from the lab to the clinic
• How clinical trials are shaping the future of ALS treatment
This session offers a powerful look at how science, medicine, and patient-centered research come together to drive innovation and hope in the ALS community.
📲 Download the EverythingALS App
• Google Play: bit.ly/4nXqIYy
• App Store: bit.ly/42tPBmh
Follow EverythingALS:
► Website: everythingals.org
► X: https://x.com/everything_als
► LinkedIn: linkedin.com/everythingals
► Facebook: facebook.com/EverythingALS
► Subscribe for more Expert Talks: youtube.com/c/everythingals
#ExpertTalk #EverythingALS #ALSResearch #GeneTherapy #PrecisionMedicine #ALSCommunity #MotorNeuronDisease #ALSScience #ALSAdvocacy #ALSAwareness #ALSUpdates #ALSExperts #CollaborativeScience
🔔 If you are passionate about advancing ALS research and understanding, like, subscribe, and turn on notifications.
Sharing this episode helps expand awareness and keeps important scientific conversations moving forward.




![Three Molecular Subtypes of ALS: #ExpertTalk with Dr. Molly Gale Hammell
In this episode of the EverythingALS Expert Talk Series, Dr. Molly Gale Hammell, Associate Professor at the Institute for Systems Genetics, NYU Langone Medical Center, explores the three molecular subtypes of ALS — stress, inflammation, and TDP-43 pathology. She shares insights into how these distinct pathways contribute to ALS progression and potential avenues for targeted treatments.
⏱ Timestamps:
00:00 - Introduction
02:15 - Understanding ALS at a molecular level
05:40 - The role of cellular stress in ALS
12:20 - Inflammation and its impact on disease progression
18:45 - TDP-43 pathology: Key mechanisms and implications
25:10 - Potential therapeutic strategies
30:00 - Q&A and audience discussion
About EverythingALS:
EverythingALS is a patient-focused nonprofit organization dedicated to accelerating the discovery of treatments and a cure for ALS through collaboration, innovation, and empowering patients and researchers.
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#ALS #MolecularSubtypes #TDP43 #Neurodegeneration #EverythingALS #ExpertTalk Three Molecular Subtypes of ALS: #ExpertTalk with Dr. Molly Gale Hammell](https://i.ytimg.com/vi/b8gFKRtmvqc/mqdefault.jpg)





