Skraup Quinoline Synthesis Mechanism | Organic Chemistry @OrganicMechanismsChannel

Uploaded November 2021 | Updated September 2026, 1 week ago

The mechanism for a Skraup reaction which involves the synthesis of a quinoline from the reaction of an aniline and glycerol in the presence of a strong acid and an oxidant. Mechanistic studies suggest that the reaction involves the reversible formation of diazetidinium ions and their irreversible cyclization to quinolines.

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