Resident Evil 5 Special Weapons: Handcannon (S&W M500 vs All Bosses) @joeekennedy
Resident Evil 5 Special Weapons: Handcannon (S&W M500 vs All Bosses)  @joeekennedy
Uploaded August 2017 | Updated September 2026, 2 days ago
This video is part of a series for Resident Evil 5. In this video I discuss the S&W M500 (Handcannon) how to unlock it, and how it stacks up against all of the bosses and sub-bosses in the game.

The S&W M500 is an extremely powerful Magnum appearing in Resident Evil 5. The M500 can only be purchased for 30,000 gold after fully upgrading the S&W M29, but completing the game is not required.

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Resident Evil 5 Special Weapons: Handcannon (S&W M500 vs All Bosses)

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