Uploaded November 2025 | Updated September 2026, 2 weeks ago
Today’s guests are *Priscilla Chan* and *Mark Zuckerberg,* co-founders of Biohub (fka Chan Zuckerberg Initiative). They are one of the leading institutes for AI x Bio and open science research with projects like CELLxGENE (https://cellxgene.cziscience.com), rbio1 (biorxiv.org/content/10.1101/2025.08.18.670981v2), VariantFormer (biorxiv.org/content/10.1101/2025.10.31.685862v1), and many more. We talked about the evolution from a broad philanthropic institute to specializing in frontier AI + bio, why they are building 12ft tall microscopes to gather better data, and how building a virtual cell model + virtual immune system could potentially help us cure all diseases.
00:00:00 Introduction and CZI's 10-Year Anniversary
00:00:56 Learning from Bill Gates
00:04:05 Science vs Translation
00:10:45 The Power of Physical Proximity in Science
00:13:55 Building the Virtual Cell: From Data to Models
00:15:51 Microscopes, Imaging, and Converting Atoms to Bits
00:23:18 AI Meets Biology: The Frontier Lab Concept
00:27:25 How Models Can Enable More Ambitious Research
00:30:15 Precision Medicine and Clinical Impact
00:45:17 The Virtual Immune System and Cellular Engineering
00:48:27 Accelerating the Timeline: What It Takes to Cure All Disease
00:28:45 Joining Forces with Evolutionary Scale
Today’s guests are *Priscilla Chan* and *Mark Zuckerberg,* co-founders of Biohub (fka Chan Zuckerberg Initiative). They are one of the leading institutes for AI x Bio and open science research with projects like CELLxGENE (https://cellxgene.cziscience.com), rbio1 (biorxiv.org/content/10.1101/2025.08.18.670981v2), VariantFormer (biorxiv.org/content/10.1101/2025.10.31.685862v1), and many more. We talked about the evolution from a broad philanthropic institute to specializing in frontier AI + bio, why they are building 12ft tall microscopes to gather better data, and how building a virtual cell model + virtual immune system could potentially help us cure all diseases.
00:00:00 Introduction and CZI's 10-Year Anniversary
00:00:56 Learning from Bill Gates
00:04:05 Science vs Translation
00:10:45 The Power of Physical Proximity in Science
00:13:55 Building the Virtual Cell: From Data to Models
00:15:51 Microscopes, Imaging, and Converting Atoms to Bits
00:23:18 AI Meets Biology: The Frontier Lab Concept
00:27:25 How Models Can Enable More Ambitious Research
00:30:15 Precision Medicine and Clinical Impact
00:45:17 The Virtual Immune System and Cellular Engineering
00:48:27 Accelerating the Timeline: What It Takes to Cure All Disease
00:28:45 Joining Forces with Evolutionary Scale
