Sulfenyl Nitrenes, Cyclopropenyl Benziodoxoles & B3H7 (Important Papers) That Chemist 2025-07-10 | Sometimes chemistry gives us the gift of crazy bonds which break the mold of what we normally think is possible. Sometimes these unusual modes of bonding enable transformations which are actually synthetically useful, as in the case of heptahydrotriborane, Ph3SN, and benziodoxoles.Support the Channel on Patreon - patreon.com/thatchemistImportant Papers Playlist - youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4References: Activating Pyridines Using B3H7 - doi.org/10.1039/d4sc03109aPreparation of KB3H8 - doi.org/10.1002/anie.201812795Functionalization of Quinolines - doi.org/10.1021/acs.orglett.4c04713Coupling Cyclopropenes - doi.org/10.1021/jacs.4c10996Sulfenyl Nitrenes/skeletal editing - doi.org/10.1126/science.adp0974deprotection of N-Ts - doi.org/10.1021/jo00872a013Selectfluor S-F - doi.org/10.1016/S0040-4039(03)01547-8PhLi - doi.org/10.1021/jo9703919NH to NBr - doi.org/10.1016/0040-4020(77)80226-3TBAF - doi.org/10.1246/cl.1992.1433Hey you read this - that means you are now obligated to have a great day!
Hypervalent Iodonium Reagents (Important Papers) That Chemist 2025-06-25 | Hypervalent iodine reagents are some powerful contemporary tools for the synthetic chemist, especially at a research level. In this video, I discuss some of the most relevant hypervalent iodine reagents for organic synthesis.Interested in synthetic consulting? Get in touch! More info at the end of the video. Interested sponsors (especially chemistry companies doing interesting chemistry) are encouraged to reach out. I am at capacity for consulting clients at the moment, but if you have an organic synthesis project which you deem as interesting, still reach out - I wanna hear about it.Important Papers covers various chemical reactions, mechanisms, and research papers in the field of organic chemistry, providing examples and explanations for each research paper.Support the Channel on Patreon - patreon.com/thatchemistImportant Papers Playlist - youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4References: Arylation of Thioethers - doi.org/10.1002/047084289X.rn01349ϐ-Arylation of Ketones - doi.org/10.1039/C5SC01636CStang’s Reagent Reacts with Tin - doi.org/10.1002/047084289X.rn00823Dearomatization, transmetallation, etc. - doi.org/10.1002/047084289X.rd005m.pub2metal free cyclopropanation - doi.org/10.1002/anie.201908994epoxidation of aldehydes - doi.org/10.1002/047084289X.rn01249nitrene precursor iodonium - doi.org/10.1002/047084289X.rt139alkynylation of nucleophilic alpha centers, alkynyl ethers, azidation, etc - doi.org/10.1002/anie.199202741Hey you read this - that means you are now obligated to have a great day!
Specialized Reagents for Carbon-Nitrogen Chemistry (Important Papers) That Chemist 2025-05-20 | TosMIC, Bredereck's Reagent, Eschenmoser's salt, and N-hydroxymethyl phthalimide - what do all of these reagents have in common? They are all able to do some powerful carbon-nitrogen chemistry. In this video, I discuss some of the most relevant reagents for carbon-nitrogen chemistry.Interested in synthetic consulting? Get in touch! More info at the end of the video. Interested sponsors are also encouraged to reach out. I am basically at capacity for consulting clients at the moment, but if you have a project which you deem as interesting, still reach out - I wanna hear about it.Important Papers covers various chemical reactions, mechanisms, and research papers in the field of organic chemistry, providing examples and explanations for each research paper.Support the Channel on Patreon - patreon.com/thatchemistImportant Papers Playlist - youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4References: TosMIC synthesis: doi.org/10.1021/acs.joc.1c01529TosMIC Eeros: doi.org/10.1002/047084289X.rt150.pub2Eschenmoser's Salt Synthesis: doi.org/10.1002/anie.197103301Eshenmoser's Salt Eeros: doi.org/10.1002/047084289X.rd346Patent example: patents.google.com/patent/WO2022140769A1Pyridylic Eschenmoser's addition: doi.org/10.1055/a-1916-5335Eschenmoser's EAS - doi.org/10.1016/j.bmc.2017.07.043Bredereck's Synthesis (part 1): doi.org/10.1021/acs.orglett.7b00793Bredereck's Synthesis Part 2: doi.org/10.1002/cber.19681010108(I couldn’t find one directly for the chloride, but the Eeros article implies it)Bredereck's Eeros: doi.org/10.1002/9780470842898.rb350.pub2N-hydroxymethylphthalimide Synthesis: doi.org/10.1002/chem.201102366EAS of N-hydroxymethylphthalimide doi.org/10.1055/s-1993-26001Hey you read this - that means you are now obligated to have a great day!
Underrated Transition Metal Reactions (Important Papers) That Chemist 2025-04-23 | Transition-metal free chemistry is a nice tagline for a research paper that probably belongs in tet let but you know the authors were hoping to trojan horse their work into Angewandte Chemie. But let's be honest - transition metals can do some pretty awesome synthetic chemistry.In this video, I share the power of rhodium catalysis for the deletion of carbonyls in aldehydes, the use of zirconium to turn alkenes and alkynes into basically anything you could want, and finally I share the power of titanium-based methods of functionalizing esters, and oh boy are there a lot of cyclopropanes in this video.Interested in synthetic consulting? Get in touch! More info at the end of the video. Interested sponsors are also encouraged to reach out. I am basically at capacity for consulting clients at the moment, but if you have a project which you deem as interesting, still reach out - I wanna hear about it.Important Papers covers various chemical reactions, mechanisms, and research papers in the field of organic chemistry, providing examples and explanations for each research paper.Support the Channel on Patreon - patreon.com/thatchemistImportant Papers Playlist - youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4References: Sugar decarbonylation (Rh) - pubs.acs.org/doi/10.1021/jo00283a017Wilkinsons catalyst for decarbonylation - doi.org/10.1002/047084289X.rc162s.pub2Catalytic rhodium for decarbonylation using a bidentate ligand - doi.org/10.1021/ja710270jEarly scope for catalytic bidentate work - doi.org/10.1002/adsc.200600228Kulinkovich review - doi.org/10.1021/cr980046zCyclopropane monstrosity - doi.org/10.1002/anie.199304011Hydrozirconation - doi.org/10.1016/B978-0-08-097742-3.00825-9Carboalumination - doi.org/10.1002/9780470682531.pat0834Hey you read this - that means you are now obligated to have a great day!
Useful Transformations of Ketals & Acetals (Important Papers) That Chemist 2025-03-05 | Ketals and acetals are more than protecting groups - they are some of the most versatile intermediates, as long as you know a few tricks to activate them.In this video, I share a creative way to prepare nucleoside derivatives (important antiviral small molecule therapeutics), I also discuss ways to displace alkoxy groups of acetals & ketals with bromide, through the use of acyl bromides. Finally I discuss the Vasella reaction, a way to prepare functional-group-rich alkenes, through the elimination of bromides and iodides alpha to an acetal, using zinc.Interested in synthetic consulting? Get in touch! More info at the end of the video. Interested sponsors are also encouraged to reach out.Important Papers covers various chemical reactions, mechanisms, and research papers in the field of organic chemistry, providing examples and explanations for each research paper.Support the Channel on Patreon - patreon.com/thatchemistImportant Papers Playlist - youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4Meanwell Lab: meanwellresearchlab.comMike Meanwell plays Liszt - Un Sospiro: youtube.com/watch?v=Nw_bbQWaBbUReferences: Meanwell Nucleoside Paper: nature.com/articles/s41467-024-51520-5ketoacetal bromodemethoxylation: doi.org/10.1021/ol991386ptribromide: doi.org/10.1021/jo991822lbenzyl methoxybromide: doi.org/10.1002/jlac.19324980107aryl ketoacetal bromodemethoxylation: doi.org/10.1002/jlac.19687160112fluoride-containing: http://dx.doi.org/10.3762/bjoc.10.173troc pyranose: http://dx.doi.org/10.1134/S1068162015020120acetyl bromide eeros: doi.org/10.1002/047084289X.ra024bromoacylation of ketones: pubs.acs.org/doi/10.1021/ja01436a0361st vasella: doi.org/10.1016/j.tet.2016.10.038N-Boc vasella: doi.org/10.1055/s-0041-1737335Paclitaxel intermediate: doi.org/10.1021/jo981749jslide 23: doi.org/10.1039/P19870001793antibiotics: doi.org/10.1016/S0040-4020(01)96261-1statin: doi.org/10.1021/ol035036lpyranose opening: patents.google.com/patent/EP1589023A1/en?oq=EP1589023A1thf-containing: doi.org/10.1021/jo991392zcarbamate vasella: doi.org/10.3987/com-95-7288chloride vasella: doi.org/10.1002/hlca.19620450727
Dithioles - A Universal Scaffold for Organic Synthesis (Important Papers) That Chemist 2025-02-25 | As there is no comprehensive reviews anywhere which showcase the versatility of these reagents, I decided to spill the beans on some of the best chemistry out there.In this video, I share what is arguably the most versatile building block in organic synthesis - the dithiole. It's like a Corey dithiane but way easier to manipulate - need to make a carbonyl? Simply use Ag2O. Want a CH2? Use Raney nickel. Mild bases can be used once you start oxidizing the dithiole to the sulfoxide(s) and sulfone forms, meaning that they can readily be alkylated or coupled with various electrophiles. You can also make them react as carbenes (from the 2-chloro-sulfone, for example)!Interested in synthetic consulting? Get in touch! More info at the end of the video. Interested sponsors are also encouraged to reach out.Important Papers covers various chemical reactions, mechanisms, and research papers in the field of organic chemistry, providing examples and explanations for each research paper.Support the Channel on Patreon - patreon.com/thatchemistImportant Papers Playlist - youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4References: Huge BDT review (1985; featuring some stuff which wasn't discussed here) - doi.org/10.1080/01961778508082475Dioxygenase ref 1 - pubs.acs.org/doi/10.1021/ja00049a004Dioxygenase ref 2 - doi.org/10.1016/j.tet.2003.10.107dithiole oxidation to sulfoxide, sulfone, and carbene chem - doi.org/10.1016/S0040-4020(01)90393-XDithiole monosulfoxide chlorination - doi.org/10.1055/s-1985-31261Lithiation of dithiole with trapping by aldehydes and ketones - doi.org/10.1016/j.tet.2003.10.107 (the dioxygenase paper)Another aldehyde/ketone paper which I don't have the DOI of - Brown, Charles Allan; Chapa, O.; Yamaichi, A.[Heterocycles, 1982, vol. 18, p. 187 - 189]Fluorination of the dithiole bis-sulfone with selectfluor - doi.org/10.1002/anie.200906866N-parameters of bis-sulfone and fluoro bis-sulfone (they dinked up the figure and had to submit a correction btw) - doi.org/10.1002/anie.2016056161,2- and 1,4- substitution of the fluoro bis sulfone - doi.org/10.1002/anie.200906866Eeros BDT-BF4 - doi.org/10.1002/047084289X.rb027Tributyltin hydride on the BDT ether and amines - pubs.acs.org/doi/10.1021/jo00003a052Adding in the mono sulfoxide into nitroarenes - doi.org/10.1080/10426509308036881imine scandium triflate cyclization - pubs.acs.org/doi/10.1021/ol020179dchloro bis-methyl acetal dithiafulvalene synthesis from dithiol - doi.org/10.1002/jhet.5570310676intramolecular domino cyclization of dithiafulvalene (aka EAS reaction) - doi.org/10.1021/jo00304a021^paper also discusses the chemoselective transformations from slide 30indole functionalization of DMBDT, difluoroether synthesis, radiofluorination, etc - doi.org/10.1002/chem.202202862My PhD thesis "New Fluorination Strategies and Reagents" -summit.sfu.ca/item/37816Trityl BF4 synthesis - https:doi.org/10.1055/s-1972-21914 (the other ways using carboxylic acid anhydrides suffer from purification issues - it is easier to do it this way if you don't hate yourself)Eeros Trityl BF4 Review - doi.org/10.1002/047084289X.rt362.pub2TTF/DTF article 1 - link.springer.com/article/10.1007/s007060200074TTF/DTF article 2 - doi.org/10.1002/chem.201802744Dear materials scientists, please make 1 product with dithiafulvalenes or tetrathiafulvalenes by 2030, otherwise the organic chemists will think you are clowningMW Dictionary - Fraud (Noun)Synonyms of fraud: deceit, trickeryspecifically : intentional perversion of truth in order to induce another to part with something of value or to surrender a legal right: an act of deceiving or misrepresenting : trick
How Do Addictive Drugs Work? That Chemist 2025-02-06 | Drugs of addiction can severely impact peoples' lives, and the biochemistry of addiction can be quite complex. People may use addictive drugs for a number of reasons, but quite often it can be associated with past trauma. Using any addictive drugs comes with many associated risks, as well as short to long-term consequences, aside from any euphoric effect which may occur. In addition, tolerance can be quickly developed to addictive drugs, which can lead to overdosing, when a break is taken from past use to the next use.The opioid crisis is widespread, especially across North America - if you happen to be carrying Narcan (Naloxone), you could save someone's life. Many pharmacies in Canada provide naloxone kits to people who might experience or witness an overdose. In the US, Narcan is available over the counter without a prescription.*Team*Producer - That Chemist (Joey)Lead Editor/Animator – DavidI also want to give a big thank you to everyone who reviewed this video ahead of time!General Addiction and Brain Function:ncbi.nlm.nih.gov/pmc/articles/PMC4549070hopkinsmedicine.org/health/conditions-and-diseases/substance-abuse-chemical-dependencyhttps://openbooks.lib.msu.edu/introneuroscience1/chapter/motivation-and-reward/yalemedicine.org/news/how-an-addicted-brain-worksPrescription Opioids (Methadone, Oxycodone, Morphine):dea.gov/resources/facts-about-fentanylFentanyl:canada.ca/en/health-canada/services/substance-use/controlled-illegal-drugs/fentanyl.htmlcdc.gov/mmwr/volumes/65/wr/mm655051e1.htmCocaine:ncbi.nlm.nih.gov/pmc/articles/PMC4460958journals.sagepub.com/doi/10.1177/1073858420974336nida.nih.gov/research-topics/cocaineNicotine:ncbi.nlm.nih.gov/pmc/articles/PMC2246082ncbi.nlm.nih.gov/pmc/articles/PMC3772953pubmed.ncbi.nlm.nih.gov/9624709Methamphetamine:ncbi.nlm.nih.gov/pmc/articles/PMC11047030ncbi.nlm.nih.gov/pmc/articles/PMC4377385ncbi.nlm.nih.gov/pmc/articles/PMC4315503Amphetamines & MDMA:journals.sagepub.com/doi/full/10.1177/0022042620988107ncbi.nlm.nih.gov/pmc/articles/PMC10316215ncbi.nlm.nih.gov/pmc/articles/PMC4194242https://www.healthdirect.gov.au/mdma-ecstasy#effectsAlcohol:https://www.montana.edu/oha/insight/MIP%20take%20home%20fact%20sheet%202.pdfhttps://www.who.int/europe/news/item/04-01-2023-no-level-of-alcohol-consumption-is-safe-for-our-healthNitrous Oxide:pubs.asahq.org/anesthesiology/article/93/4/1095/38687/Effects-of-Gaseous-Anesthetics-Nitrous-Oxide-andpubs.asahq.org/anesthesiology/article/51/4/309/26071/Tolerance-to-Nitrous-Oxide-Analgesia-in-Rats-andparents.com/what-is-galaxy-gas-8714373Optical rotation (what chemists use when discussing enantiomers):en.wikipedia.org/wiki/Optical_rotation
Underrated Reducing Agents (Important Papers) That Chemist 2025-01-07 | Interested in boosting success rates in synthesis route design and prediction using the Predictive Retrosynthesis Tool from Reaxys? Find out more information here - beta.elsevier.com/products/reaxys/predictive-retrosynthesis?utm_campaign=prt-integration-ads&utm_source=thatchemist&utm_medium=video&dgcid=RN_AG_Sourced_400004103Important Papers covers various chemical reactions, mechanisms, and research papers in the field of organic chemistry, providing examples and explanations for each research paper.In this video, I discuss reducing agents which deserve more attention! Including Aluminum isopropoxide, Red-Al aka Vitride, Raney Nickel, and TFA/triethylsilane. Each of these reductants works by distinct mechanisms, which is great for complementary reactivity!Make sure you share this series with other chemists in your network, especially ones who don't usually watch YouTube! Support the Channel on Patreon - patreon.com/thatchemistImportant Papers Playlist - youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4Interested in synthetic consulting? Get in touch! More info at the end of the video.-----------------------------------------References:aluminum isopropoxide review - 10.1002/047084289X.ra084.pub2aluminum isopropoxide synthetic protocol (videos of the synthesis were from my own runs) - https://starklab.de/index.php/2021/12/28/synthesis-of-aluminium-isopropoxide/Red-Al synthesis - patents.google.com/patent/US3728272A/enRed-Al review - 10.1002/9780470842898.rs049.pub2Raney Nickel review - 10.1002/047084289X.rr001.pub2TFA/TES review - 10.1002/047084289X.rt227.pub2Triethylsilyl chloride synthesis - pubs.acs.org/doi/10.1021/ja01211a501triethylsilane synthesis - patents.google.com/patent/CN113880875A/en-----------------------------------------
Tasting PURE Tear Gas (PAVA/Nonivamide) #science #chemistry That Chemist 2024-12-02 | This is a clip of (my) human suffering from a video where I taste some of the spiciest chemicals on chicken wings and in their pure form!From this video here - youtu.be/0AdpdPBHJHo
CF2 and SF5 Chemistry (Important Papers) That Chemist 2024-12-02 | Interested in boosting success rates in synthesis route design and prediction using the Predictive Retrosynthesis Tool from Reaxys? Find out more information here - beta.elsevier.com/products/reaxys/predictive-retrosynthesis?utm_campaign=prt-integration-ads&utm_source=thatchemist&utm_medium=video&dgcid=RN_AG_Sourced_400004103Important Papers covers various chemical reactions, mechanisms, and research papers in the field of organic chemistry, providing examples and explanations for each research paper.In this video, I discuss some of the best ways to add CF2 and SF5 groups using decent methodology.Make sure you share this series with other chemists in your network, especially ones who don't usually watch YouTube! Support the Channel on Patreon - patreon.com/thatchemistImportant Papers Playlist - youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4-----------------------------------------References:CF2H review - 10.1002/ajoc.201600509Photoredox CF2H - 10.1002/anie.201807629SF5 Review - 10.1055/a-1845-9291Other SF5 Cl to F exchange papers:HF: patents.google.com/patent/WO2012111839A1/en?oq=WO2012111839A1ZnF2: http://dx.doi.org/10.3762/bjoc.8.53IF5: pubs.rsc.org/en/content/articlelanding/2017/cc/c7cc02802dSbF5: http://dx.doi.org/10.3762/bjoc.8.53AgBF4: http://dx.doi.org/10.1246/bcsj.20210109KHF2: pubs.acs.org/doi/10.1021/acs.joc.6b02276HF/Pyridine: patents.google.com/patent/WO2010014665A1/en?oq=WO2010014665A1BONUS - Ag2CO3 also works (thanks to Semp_ukiuki!) - doi.org/10.1039/C7CC07222H (2 equiv of Ar-SF4Cl become 1 equiv of Ar-SF5)-----------------------------------------
Which Chemical is the Most Spicy? That Chemist 2024-11-19 | 🌏 Get NordVPN 2Y plan + 4 months extra ➼ nordvpn.com/thatchemist It’s risk-free with Nord’s 30-day money-back guarantee! ✌Capsaicin is the spiciest chemical we regularly eat, or is it? I am putting that to the test by rawdogging 9 spicy chemicals, and also seeing how they fair on chicken wings! I asked you, the viewers, how I should suffer, and it was a close call between rawdogging and chicken wings, so naturally I did both.I weighed out each of the pure spicy chemicals to make sure I didn't get a trip to the hospital, pure spicy compounds are what they use in pepper spray after all! Do not use this video as an endorsement to subject yourself or others to intense pain - I did it so that you don't have to. Some of the compounds are pretty safe to work with, but capsaicin and nonivamide are extremely potent. Beware.Support the Channel on Patreon - patreon.com/thatchemist*Team*Producer - That Chemist (Joey)Writer - ScorpLead Editor/Animator – David
My Strongest Solvent Grudges Revealed That Chemist 2024-08-16 | Sometimes solvents can be really useful, and other times they can turn a 30-minute drying step into an overnight drying step - but there are a whole lot of ways that solvents can ruin your day (or destroy your organs).Support the Channel on Patreon - patreon.com/thatchemistJoin the Community Discord! - discord.gg/thatchemist*Team*Producer - That Chemist (Joey)
Which Chemical is the Most Savory? (Umami Lore) That Chemist 2024-08-09 | Don't miss out on designing your dream set up with FlexiSpot. Use my exclusive code '24BDYTB30' for extra $30 off on E7, E7 Pro and E7L. Trust me, it's a rare treat!FlexiSpot E7 Pro standing desk: bit.ly/3YAPQuC - USbit.ly/3SEQnYJ - CanadaMSG is the king of flavor... or is it? Let's discuss the science behind umami flavor, and taste the well known umami chemicals.Support the Channel on Patreon - patreon.com/thatchemistJoin the Community Discord! - discord.gg/thatchemist*Team*Producer - That Chemist (Joey)Writer - ScorpLead Editor/Animator – David
Deoxy-Fluorine Chemistry (Important Papers) That Chemist 2024-07-20 | Interested in boosting success rates in synthesis route design and prediction using the Predictive Retrosynthesis Tool from Reaxys? Find out more information here - beta.elsevier.com/products/reaxys/predictive-retrosynthesis?utm_campaign=prt-integration-ads&utm_source=thatchemist&utm_medium=video&dgcid=RN_AG_Sourced_400004103Important Papers covers various chemical reactions, mechanisms, and research papers in the field of organic chemistry, providing examples and explanations for each research paper.In this video, I discuss major articles from fluorine chemistry which are widely overlooked by the majority of synthetic chemists - these are the bread and butter of fluorine chemistry. In this video, I focus on deoxy-fluorination strategies including direct deoxyfluorination, radical deoxyfluorination, and radical deoxy trifluoromethylation and difluoromethylation.Make sure you share this series with other chemists in your network, especially ones who don't usually watch YouTube! Support the Channel on Patreon - patreon.com/thatchemistImportant Papers Playlist - youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4-----------------------------------------References:Deoxyfluorination review - 10.1039/d1qo00952dDeoxy-trifluoromethylation - 10.1021/jacs.2c04807Deoxy-difluoromethylation - 10.1021/jacs.3c14460-----------------------------------------
Which Chemistry Resource is the Most Useful? That Chemist 2024-07-19 | Chemistry can seem intimidating, but there are a lot of resources that make it easier to understand. In this video, I discuss numerous resources which have been valuable to myself and others when doing chemistry. Are there any good resources I missed? Drop a comment down below so that other mouth-pipetters can reap the benefits of your valuable experience.Support the Channel on Patreon - patreon.com/thatchemistJoin the Community Discord! - discord.gg/thatchemist*Team*Producer - That Chemist (Joey)*Links*Wikipedia - en.wikipedia.orgPubChem - pubchem.ncbi.nlm.nih.gov/compound/BenzotrifluorideChemistry LibreTexts - chem.libretexts.orgPubPeer - pubpeer.comReaxys - reaxys.comScifinder - scifinder-n.cas.orgThe Chemical Rubber Company Handbook (pdfs can be found)Mayr's Database - https://www.cup.lmu.de/oc/mayr/reaktionsdatenbank2Organic Chemistry Portal - organic-chemistry.orgGoogle Patents - patents.google.comGoogle Scholar - scholar.google.comMolview - molview.orgWikipedia Chemical Structure Explorer - wikipedia.cheminfo.orgUllmann's Encyclopedia of Industrial Chemistry (pdfs can be found)SDBS - sdbs.db.aist.go.jpBordwell pKa Table - organicchemistrydata.org/hansreich/resources/pkaThe Merck Index (pdfs can be found)Organic Syntheses - orgsyn.orgNIST - webbook.nist.govLigma Baldrich Nomograph - https://rb.gy/h8j259NotVoodooX - https://www.chem.rochester.edu/notvoodoo/Scihub (mirrors change sometimes) - https://sci-hub.seeEROS - onlinelibrary.wiley.com/page/book/10.1002/047084289x/homepage/whatsnew.htmlLibgen - https://libgen.is/Chemistry by Design - https://chemistrybydesign.oia.arizona.edu/app/Reactionflash - elsevier.com/products/reaxys/higher-education/teaching-chemistry/reaction-flash
Which Explosive is the Most Illegal? (Explosives Lore) That Chemist 2024-07-12 | DO NOT MAKE EXPLOSIVES!In this video, we discuss the most dangerous explosives. We categorize them by their legality, danger, stability and toxicity.Even if you think you are able to safely prepare explosive compounds, you are probably wrong. There is a fluorine chemist named Darryl Desmarteau who was a chemistry professor researching energetic fluorinated materials. One day, when his researchers were out of the lab, he went to check on the lab, as any responsible supervisor does. As he was checking on his students' experiments, he reached out to take a closer look at one flask, and in that moment, it went off. When he ran to the lab phone to dial 911, the phone didn't respond, because he didn't have a hand anymore. Please consider the safety of yourself and those around you, as even trained experts have been maimed from experiments of scientific value.Support the Channel on Patreon - patreon.com/thatchemistJoin the Community Discord! - discord.gg/thatchemistTimestamps:Intro: 0:00 - 4:03FÜM Ad: 4:03 - 4:57Acetone Peroxide: 4:57 - 8:29Blackpowder: 8:29 - 12:11Flash Powder: 12:11 - 15:45HMTD: 15:45 - 17:21Acetylene: 17:21 - 20:19Mercury (II) Fulminate: 20:19 - 22:11Nitroglycerin: 22:11 - 23:51PLX: 23:51 - 26:12Trinitrotoluene (TNT): 26:12 - 29:22RDX (Hexogen): 29:22 - 31:10HMX (Octogen): 31:10 - 32:42Ammonium Nitrate: 32:42 - 36:55Picric Acid: 36:55 - 39:11ETN & PETN: 39:11 - 41:06Azides: 41:06 - 44:29Outro: 44:29 - 44:53FÜM Ad Outro: 44:53 - 44:56 *Team*Producer - That Chemist (Joey)Research/Scripting/Animator/Editor – DavidA huge thanks to the people who helped with this video, including:-Opossum Supremacist (reviewed completeness of tierlist, assisted in military-related questions)-Doyale (German translation, chemistry-related questions)-Ballerene & Indescension (SLAP round)-Nicolau, Laz, LWJ (picric acid corrections)-Mfernflower (Azidoazido azide enthusiast)*Links*All links can be found on pastebin, where there is no character limit:pastebin.com/k5ND9ECW
Which Greenhouse Gas is the Worst? That Chemist 2024-07-05 | The greenhouse effect keeps life on our planet going, but if it gets too hot that ain't so good. In this video, we investigate the most common greenhouse gases, their global warming potentials (GWPs), and discuss concerns related to their emissions.Support the Channel on Patreon - patreon.com/thatchemistJoin the Community Discord! - discord.gg/thatchemist*Team*Producer - That Chemist (Joey)
Key CF3 Chemistry (Important Papers) That Chemist 2024-07-02 | Interested in boosting success rates in synthesis route design and prediction using the Predictive Retrosynthesis Tool from Reaxys? Find out more information here - beta.elsevier.com/products/reaxys/predictive-retrosynthesis?utm_campaign=prt-integration-ads&utm_source=thatchemist&utm_medium=video&dgcid=RN_AG_Sourced_400004103Important Papers covers various chemical reactions, mechanisms, and research papers in the field of organic chemistry, providing examples and explanations for each research paper.In this video, I discuss major articles from fluorine chemistry which are widely overlooked by the majority of synthetic chemists - these are the bread and butter of fluorine chemistry.Make sure you share this series with other chemists in your network, especially ones who don't usually watch YouTube! Support the Channel on Patreon - patreon.com/thatchemistImportant Papers Playlist - youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4-----------------------------------------References:Trifluoromethyltrimethylsilane: Nucleophilic Trifluoromethylation and Beyond - doi.org/10.1021/cr400473aTogni Reagents – Electrophilic CF3 - doi.org/10.1021/cr500223hAdvances in the Development of Trifluoromethoxylation Reagents - pubs.acs.org/doi/10.3390/sym13122380Efficient Difluoromethylation of Alcohols Using TMSCF2Br - onlinelibrary.wiley.com/doi/abs/10.1002/anie.201611823Org syn prep of togni reagent: doi.org/10.15227/orgsyn.088.0168TMSCF2Br synthesis: doi.org/10.1016/j.jfluchem.2018.01.009-----------------------------------------
Which Artificial Sweetener is the Best? (Artificial Sweetener Lore) That Chemist 2024-06-01 | Calories weigh heavily on a lot of people, but people try to reduce the intake of calories by using artificial sweeteners - let's talk about what they are and taste which one is best.If you’re looking for another video to watch, we also tasted a bunch of sugars in a previous video - Which Sugar Tastes the Best? (Sugar Lore)youtu.be/zcw7I5bT4GkSupport the Channel on Patreon - patreon.com/thatchemistJoin the Community Discord! - discord.gg/thatchemistBackup discord link: discord.gg/n5qtKjyRxN*Team*Producer - That Chemist (Joey)Lead Writer/Editor – @CiggySnakeCowriter - Scorp
Which Chemical is the Most Bitter? (Bitter Lore) That Chemist 2024-05-13 | Thanks to Listening for sponsoring this video! Get Listening using my link to let Listening know that you came from here! listening.1stcollab.com/that_chemistWe tasted a bunch of bitter chemicals, and some of them were absolutely vile.Support the Channel on Patreon - patreon.com/thatchemistJoin the Community Discord! - discord.gg/thatchemist*Team*Producer - That Chemist (Joey)Writer - ScorpLead Editor/Animator – @reformlabs1050 A big thanks to Brendin (FrawggyFresh twitch.tv/frawggyfresh) and Victor (Victor E) for suffering with me – also a big thank you to @MaxTheCatfish @ImKibitz and @CocktailTimeJR for the PTC tasting at the end of the video!
Major Methods in Radical Chemistry (Important Papers) That Chemist 2024-04-30 | Interested in boosting success rates in synthesis route design and prediction using the Predictive Retrosynthesis Tool from Reaxys? Find out more information here - beta.elsevier.com/products/reaxys/predictive-retrosynthesis?utm_campaign=prt-integration-ads&utm_source=thatchemist&utm_medium=video&dgcid=RN_AG_Sourced_400004103Important Papers covers various chemical reactions, mechanisms, and research papers in the field of organic chemistry, providing examples and explanations for each research paper.In this video, I discuss four major review articles from four fields of radical chemistry which are widely overlooked by the majority of synthetic chemists.Make sure you share this series with other chemists in your network, especially ones who don't usually watch YouTube! I want to thank Maurice Hietkamp for his help with this episode :)Support the Channel on Patreon - patreon.com/thatchemistJoin the Community Discord! - discord.gg/thatchemistBackup Discord link - discord.gg/QWNPETtPcZImportant Papers Playlist - youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4-----------------------------------------References:Thirty Years of (TMS)3SiH: A Milestone in Radical-Based Synthetic Chemistry - doi.org/10.1021/acs.chemrev.8b00109Discovery and Development of Organic Super-Electron-Donors - doi.org/10.1021/jo500071uMetallaphotoredox: The Merger of Photoredox and Transition Metal Catalysis - pubs.acs.org/doi/10.1021/acs.chemrev.1c00383Radical Deoxyfunctionalisation Strategies - onlinelibrary.wiley.com/doi/abs/10.1002/ejoc.202200330-----------------------------------------
Turning into Venom in Chem Lab... with Tar That Chemist 2024-04-12 | This is an episode in the Extreme Chempilation series - expect mild profanity and stories that some viewers may find disturbing.One of this stories involves someone getting nitric acid in their eyes - what the heck is wrong with some of y'allDO NOT EAT OR DRINK LAB CHEMICALS! 💀💀💀I want to give a huge thanks to all the supporters of the channel on Patreon!patreon.com/thatchemistJoin the Community Discord! - discord.gg/thatchemist*Team*Producer/Host - Joey (That Chemist)Production Assistant/Editor - Exergonick (MVP)
The Chemistry Clamp Tierlist That Chemist 2024-03-29 | Now is the best time to buy the FlexiSpot Ergonomic Chair. 30 days free return, try it with confidence! Use code "C730" for $30 off!FlexiSpot C7 Premium Ergonomic ChairUS: tinyurl.com/y8mp3tkvCA: tinyurl.com/bdhn8a7zThanks to Flexispot for sponsoring this video!Lab clamps are still terrible - they can take their 3-fingers and grab onto tar for all I care.Support the Channel on Patreon - patreon.com/thatchemistJoin the Community Discord! - discord.gg/thatchemistSecond Discord link if the first one is borked - discord.gg/QWNPETtPcZ----------------------------------------------------------------------------------------------------------------------------------Links to clamps et al discussed in this video (they are amazon.ca affiliate links but most of you are likely american so have fun finding them on amazon.com):smallrig 2 pack of clamps amzn.to/3TMDaOEsmallrig blue mount amzn.to/3TMDaOENeewer overhead mount amzn.to/3IKZJNcNeewer beefy clamp amzn.to/3vcZtUdJOBY magnetic tripod amzn.to/4apgCJeJOBY arms amzn.to/3vm3tl9sound card tray amzn.to/43smDCw----------------------------------------------------------------------------------------------------------------------------------
How do allergies work? (Allergen Lore) That Chemist 2024-03-14 | Cats are cool but I can't get too close to them - it's pretty dumb that being near a specific animal can make my immune system get triggered.Support the Channel on Patreon - patreon.com/thatchemistJoin the Community Discord! - discord.gg/thatchemistSecond Discord link if the first one is borked - discord.gg/QWNPETtPcZ*Team*Editor/Producer/Thumbnail Artist - That Chemist (Joey)Writer - ScorpLead Editor/Animator – @reformlabs1050 Helpful ppl:Trevor: Helped with information concerning the B-Cell ReceptorScorp: Help with Peptidoglycan SegmentBallerene: Help with Peptidoglycan segmentNick: Assisted with the Antigen SegmentMatthew: Assisted with the Pink Planet in the New Tierlist formatEjkozan: Assistance with Ninhydrin & DCC part
‘Testing’ the Blower That Chemist 2024-02-09 | So my friend @tesla500 is basically Tony Stark, and he let us play with one of his inventions - the blower.
Poking a hole in hot glass so I can get tar out of my flask That Chemist 2024-02-02 | Lucas helped me poke some holes in my 5000 mL flask and we connected a couple new joints which cost like $4 each to my $99 flask - just get it hot and poke a hole! It helps if you have a glass lathe though 🫠
Which Chemical is the Best Antibiotic? (Antibiotic Lore) That Chemist 2024-01-20 | Bacteria are the worst when they mess stuff up, but normally we need them, cause hey are pretty cool, but bacteria in hospitals suck - that's where SARS happens :/Check out @CiggySnake’s video here: youtu.be/N4WODXLL_fsSupport the Channel on Patreon - patreon.com/thatchemistJoin the Community Discord! - discord.gg/thatchemistSecond Discord link if the first one is borked - discord.gg/QWNPETtPcZ*Team*Editor/Producer/Thumbnail Artist - That Chemist (Joey)Writer/Lead Editor – @CiggySnake
Finally a Functioning Still (liters of methyl acetate) That Chemist 2024-01-18 | This is the pilot run of my 5L still - I am distilling some methyl acetate that I was isolating from paint stripper - I’m using the vigreaux column to separate 1,3-dioxolane and DMSO from D Super Remover (New Generation Stripper)
Tearing up the Juul in Chem Lab That Chemist 2024-01-13 | This is an episode in the Extreme Chempilation series - expect mild profanity and stories that some viewers may find disturbing.Did you know that concentrated nicotine products are acutely toxic? Don't get nicotine on your family juulsDO NOT EAT OR DRINK LAB CHEMICALS! 💀💀💀I want to give a huge thanks to all the supporters of the channel on Patreon!patreon.com/thatchemistJoin the Community Discord! - discord.gg/thatchemist*Team*Producer/Host - Joey (That Chemist)Production Assistant/Editor - Exergonick (MVP)Music (from FTL - Ben Prunty)
Where is the best place to buy chemicals? That Chemist 2024-01-04 | I disabled YouTube Adsense on the channel - any ads you see on youtube are not affiliated with 'That Chemist' or myself, nor do they reflect my views. The recent censorship and overreach on youtube has gone too far.Let's be honest - Ligma Baldrich is robbing all of us and all they are doing is buying their chemicals from the vendors that you could also buy from! #stopsigmaSupport the Channel on Patreon - patreon.com/thatchemistJoin the Community Discord! - discord.gg/thatchemistSecond Discord link if the first one is borked - discord.gg/QWNPETtPcZ*Team*Editor/Producer/Thumbnail Artist - That Chemist (Joey)Lead Editor – @reformlabs1050 (David)AI Wrangler - BirdAmazon Canada amazon.caAmazon US amazon.comEbay ebay.comHome Depot homedepot.comMystic Moments mysticmomentsuk.comUS Pigments Corp uspigment.comBulk Supplements bulksupplements.comOnyxmet onyxmet.com (doesnt even show up when I googled it)Xenex xenexlabs.comScience Company sciencecompany.comCarolina Chemical carolinachemical.comPerfumer's Apprentice shop.perfumersapprentice.comPerfumers World perfumersworld.comStrem strem.comFluorochem fluorochem.co.ukCombiblocks combi-blocks.comAli Express aliexpress.comAK Scientific aksci.comLigma Baldrich is not getting their URL listedAmbeed ambeed.comBLD bldpharm.comEnamine new.enaminestore.comRoth carlroth.com/com/enOakwood oakwoodchemical.com (one time I tried to find their website on google when I was in oakwood, ON and they didnt show up at all)Voyageur voyageursoapandcandle.comCanadian Tire canadiantire.ca/en.htmlFB Marketplace facebook.com/marketplaceStellar Chemical Corp stellarchemicalcorp.com (doesnt even show up when I googled it)Activate Scientific shop.activate-scientific.comCIL isotope.comSynquest synquestlabs.comBio-Basic biobasic.comCaledon caledonlabs.com/home.phpChemsavers chemsavers.comEtsy etsy.comManchester Organic manchesterorganics.comPell Wall pellwall.comPerfumer supply house perfumersupplyhouse.comChemCraft https://chemcraft.su/TCI tcichemicals.comTRC trc-canada.comMatrix Scientific matrixscientific.com (doesnt even show up when I googled it)Synthonix synthonix.comPlastic World plasticworld.caRona rona.comHome Hardware homehardware.caAlfa Aesar http://www.alfa.comThermoFischer thermofisher.comVWR vwr.comBlasta Deck is also not getting their website listed.
His laser cutter formed deadly phosgene That Chemist 2023-12-31 | This is an episode in the Extreme Chempilation series - expect mild profanity and stories that some viewers may find disturbing.if you use lasers, please do not cut chlorinated plastics - honestly like if you dont know what a laser does to a specific material, maybe like you should do a google search first - maybe a good idea.DO NOT EAT OR DRINK LAB CHEMICALS! 💀💀💀I want to give a huge thanks to all the supporters of the channel on Patreon!patreon.com/thatchemistJoin the Community Discord! - discord.gg/thatchemist*Team*Producer/Host - Joey (That Chemist)Production Assistant/Editor - Exergonick (MVP)
How I became a PhD in Chemistry That Chemist 2023-12-13 | Subject: Josiah NewtonTopic: PhD Thesis Defence Examination Stardate: December 8th, 2023Outcome: PassedBrief: This was my PhD Thesis presentation, which was the culmination of my work as a researcher. If there is interest among the viewers, I may make a more detailed video in the future. Dr. Joey out.Complete thesis (online): summit.sfu.ca/item/37816
Every Type of Chemistry Explained That Chemist 2023-12-06 | Thanks to Bespoke Post for sponsoring this video! New subscribers get 20% off their first box — go to bespokepost.com/thatchemist20 and enter code THATCHEMIST20 at checkout.What is chemistry? Well it turns out it's not just one thing - it's a whole bunch of things! Anal chemistry was a painful course to take, it was a real pain in the butt.Support the Channel on Patreon - patreon.com/thatchemistJoin the Community Discord! - discord.gg/thatchemistSecond Discord link if the first one is borked - discord.gg/QWNPETtPcZEditor/Producer/Thumbnail Artist - That Chemist (Joey)Lead Editor – @reformlabs1050 (David)
The Flame Lathe That Chemist 2023-11-17 | Thanks to Lucas Clarke for showing me how to make a round bottom flask :)!
A New Bioisostere of Adamantane That Chemist 2023-11-08 | Important Papers covers various chemical reactions, mechanisms, and research papers in the field of organic chemistry, providing examples and explanations for each research paper.In this video, I discuss five important papers in organic synthesis that were published around October 2023. Make sure you share this series with other chemists in your network, especially ones who don't usually watch YouTube! I want to thank Maurice Hietkamp for his help with this episode :)Support the Channel on Patreon - patreon.com/thatchemistJoin the Community Discord! - discord.gg/thatchemistBackup Discord link - discord.gg/QWNPETtPcZImportant Papers Playlist - youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4-----------------------------------------References:Cephalotanin doi.org/10.1002/anie.202312599Scandium doi.org/10.1021/acs.orglett.3c02734Hydroamination doi.org/10.1021/jacs.3c08428Bioisostere doi.org/10.1038/s41467-023-41298-3NBS in DMF doi.org/10.1021/acs.oprd.3c00104-----------------------------------------Honorable mentions:Azoxy Compounds—From Synthesis to Reagents for Azoxy Group Transfer Reactions doi.org/10.1002/anie.202312031Enantioselective Total Syntheses of (−)-Caulamidine D and (−)-Isocaulamidine D and Their Absolute Configuration Reassignment doi.org/10.1021/jacs.3c08714Reductive N-Formylation of Nitroarenes Mediated by Rongalite doi.org/10.1021/acs.orglett.3c02839Overcoming Deactivation of Amine-Based Catalysts: Access to Fluoroalkylated γ‑Nitroaldehydes doi.org/10.1021/jacs.3c08198Deoxyfluorination of 1°, 2°, and 3° Alcohols by Nonbasic O−H Activation and Lewis Acid-Catalyzed Fluoride Shuttling doi.org/10.1021/jacs.3c08373Desulfurative Borylation of Small Molecules, Peptides, and Proteins doi.org/10.1021/jacs.3c09081
Which Chemical is the Best Disinfectant? (Disinfectant Lore) That Chemist 2023-11-05 | Antlion Audio is giving 15% off for viewers who use code thatchemist at checkout - head over to antlionaudio.com/?ref=thatchemist to get your very own modmic wireless! Using that link helps support the channel :)Bleach really exists in your body? Propylene glycol disinfects the air? Apparently. Maybe that means people who vape are sterilizing the room? Fat rips season? Probably not.Support the Channel on Patreon - patreon.com/thatchemistJoin the Community Discord! - discord.gg/thatchemistSecond Discord link if the first one is borked - discord.gg/QWNPETtPcZ*Team*Editor/Producer/Thumbnail Artist - That Chemist (Joey)Writer/Researcher - Scorp (Barry)Lead Editor – @reformlabs1050 (David)*Music* - A huge thanks to @S3RL for letting us use his music in the video! the song for the phenol montage is "Intensify - S3RL"Contact S3RL - withkoji.com/@S3RL
The Plant Irritant Tierlist (Plant Irritant Lore) That Chemist 2023-11-04 | Subscribe to Curiosity Stream and start exploring the world around you! bit.ly/CuriosityStreamThatChemist1123Plants can just poke you and then you need to go to the hospital? That sure is irritating.Support the Channel on Patreon - patreon.com/thatchemistJoin the Community Discord! - discord.gg/thatchemistSecond Discord link if the first one is borked - discord.gg/QWNPETtPcZ*Team*Writer/Producer/Thumbnail Artist - That Chemist (Joey)Lead Writer/Editor – @CiggySnake
What are Super Bases? (Super Base Lore) That Chemist 2023-10-17 | Go to https://ground.news/thatchemist to know where your information is coming from. Get 30% off their unlimited vantage plan or try out their pro plan for less than $1/month.Super bases are extremely strong bases, so strong that they get their own special designation. You must be super based if you are watching this video.Support the Channel on Patreon - patreon.com/thatchemistJoin the Community Discord! - discord.gg/thatchemistSecond Discord link if the first one is borked - discord.gg/QWNPETtPcZ*Team*Writer/Producer/Thumbnail Artist - That Chemist (Joey)Lead Animator/Graphic Designer/Editor – DavidVinamidine paper - onlinelibrary.wiley.com/doi/abs/10.1002/anie.198711641PKBH table - doi.org/10.2478/s11532-010-0044-9Physico-Chemical Properties of Organosuperbases -doi.org/10.1002/9780470740859.ch2Pandora's Phosphazene - onlinelibrary.wiley.com/doi/10.1002/anie.199313611DMF/DMSO/DMA + NaH hazards - pubs.acs.org/doi/10.1021/acs.oprd.9b00276
Chemistry has OSHA because of stuff like this That Chemist 2023-10-06 | You can get your very own Eco Funnels by going to calpaclab.com/eco-funnels and using code *thatchemist10* to get 10% off site-wide. Thanks to CP Lab Safety for supporting the channel!This is an episode in the Extreme Chempilation series - expect mild profanity and stories that some viewers may find disturbing.DO NOT EAT OR DRINK LAB CHEMICALS! 💀💀💀I want to give a huge thanks to all the supporters of the channel on Patreon!patreon.com/thatchemistJoin the Community Discord! - discord.gg/thatchemist*Team*Producer/Host - Joey (That Chemist)Production Assistant/Editor - Exergonick
Two Novel Approaches to Make Ethers That Chemist 2023-09-29 | Interested in boosting success rates in synthesis route design and prediction using the Predictive Retrosynthesis Tool from Reaxys? Find out more information here - beta.elsevier.com/products/reaxys/predictive-retrosynthesis?utm_campaign=prt-integration-ads&utm_source=thatchemist&utm_medium=video&dgcid=RN_AG_Sourced_400004103Important Papers covers various chemical reactions, mechanisms, and research papers in the field of organic chemistry, providing examples and explanations for each research paper.In this video, I discuss five important papers in organic synthesis that were published around September 2023. Make sure you share this series with other chemists in your network, especially ones who don't usually watch YouTube! I want to thank Maurice Hietkamp for his help with this episode :)Support the Channel on Patreon - patreon.com/thatchemistJoin the Community Discord! - discord.gg/thatchemistBackup Discord link - discord.gg/QWNPETtPcZImportant Papers Playlist - youtube.com/playlist?list=PL6OLqxmk7RtyRkdJhXK8NWpT1krGNq1p4-----------------------------------------References:Ethers from esters doi.org/10.1021/acs.orglett.3c02643Sulfonamides from alcohols doi.org/10.1021/jacs.3c08216Ethers from carbonyls doi.org/10.1021/acs.joc.3c00822BMIDA acrolein doi.org/10.1021/acscatal.3c03474Nitrosyl Triflate doi.org/10.1021/acs.orglett.3c02700-----------------------------------------Honorable mentions:Ergoline Synthesis doi.org/10.1021/acs.joc.3c01363C−H Fluorination of Quinolines doi.org/10.1021/jacs.3c07119Aryl (β,β′,β″-Trifluoro)-tert-butyl doi.org/10.1021/acs.orglett.3c02236 Carbenes Derived from Dichloromethane doi.org/10.1002/anie.202308913The NBS DMF OPRD paper doi.org/10.1021/acs.oprd.3c00104
What are Super Acids? (Super Acid Lore) That Chemist 2023-09-26 | Super acids are extremely strong acids, so strong that they get their own special designation. Are you a registered super acid?Support the Channel on Patreon - patreon.com/thatchemistJoin the Community Discord! - discord.gg/thatchemistSecond Discord link if the first one is borked - discord.gg/QWNPETtPcZ
