Young people are a priority now, not just for the future (BSL-interpreted) The Lancet 2024-10-22 | Young people are a priority now, not just for the future (BSL-interpreted)
The Lancet Countdown 2022: Dr Paula Henry The Lancet 2022-10-31 | The 2022 report of the Lancet Countdown on health and climate change Read the full report at thelancet.com/countdown-health-climate
The Lancet Countdown 2022: Dr Omnia El Omrani The Lancet 2022-10-31 | The 2022 report of the Lancet Countdown on health and climate change Read the full report at thelancet.com/countdown-health-climate
The Lancet Countdown 2022: Dr Courtney Howard The Lancet 2022-10-31 | The 2022 report of the Lancet Countdown on health and climate change Read the full report at thelancet.com/countdown-health-climate
The Lancet Countdown 2022: Byron Chapoterera The Lancet 2022-10-31 | The 2022 report of the Lancet Countdown on health and climate change Read the full report at thelancet.com/countdown-health-climate
The Lancet Countdown 2022: Berhe Tesfay The Lancet 2022-10-31 | The 2022 report of the Lancet Countdown on health and climate change Read the full report at thelancet.com/countdown-health-climate
The Lancet Countdown on Health and Climate Change: 2022 Global Launch Event The Lancet 2022-10-31 | Global launch event for the 2022 Lancet Countdown on Health and Climate Change.Read the full report at: thelancet.com/countdown-health-climate
The Lancet Countdown on Health and Climate Change: 2022 report The Lancet 2022-10-26 | The 2022 report of the Lancet Countdown on health and climate change Read the full report at thelancet.com/countdown-health-climate
Inequality in Cancer Care for People with a Disability (BSL-interpreted) | The Lancet Oncology The Lancet 2022-10-24 | People with a disability are often less likely to receive adequate medical care, due in part to misconceptions and lacking resources on the part of practitioners. Dr Lisa Iezzoni speaks on the subject of inequality in cancer care for people with a disability.To view this film without British Sign Language interpretation, go to youtu.be/bIKTcNv17RIFind out more at thelancet.com/series/disabilities-and-cancer----Pexels FootageAndrey Kirievskiy: pexels.com/@andrey-kirievskiy-1404180Cliff Booth: pexels.com/@cliff-boothKampus Production: pexels.com/@kampusMikhail Nilov: pexels.com/@mikhail-nilovShotPot: pexels.com/@shotpotTima Miroshnichenko: pexels.com/@tima-miroshnichenko
Inequality in Cancer Care for People with a Disability | The Lancet Oncology The Lancet 2022-10-24 | People with a disability are often less likely to receive adequate medical care, due in part to misconceptions and lacking resources on the part of practitioners. Dr Lisa Iezzoni speaks on the subject of inequality in cancer care for people with a disability.This film is also available with British Sign Language interpretation at: youtu.be/Ob6HpIHPpQkFind out more at thelancet.com/series/disabilities-and-cancer----Pexels FootageAndrey Kirievskiy: pexels.com/@andrey-kirievskiy-1404180Cliff Booth: pexels.com/@cliff-boothKampus Production: pexels.com/@kampusMikhail Nilov: pexels.com/@mikhail-nilovShotPot: pexels.com/@shotpotTima Miroshnichenko: pexels.com/@tima-miroshnichenko
Clinical Picture | Searching for a cause of a gastric ulcer that didn’t heal The Lancet 2022-10-22 | Cytomegalovirus causes non-healing gastric ulcer in immunocompromised man
Poems from people with lived experience of mental health conditions The Lancet 2022-10-10 | Hear several poems, read aloud by the poets, about their experiences of stigma and discrimination as a person living with a mental health condition.Find out more about The Lancet Commission on Ending Stigma and Discrimination in Mental Healthat thelancet.com
Supplementary video: A patient’s experience with home monitoring of pulmonary fibrosis The Lancet 2022-10-04 | The video shows a patient discussing his experience with home monitoring and how it fits in to hospital appointments and his daily life. He shows how he uses a handheld spirometer to measure forced vital capacity and the online application to answer questions, record side-effects, and keep in touch with cliniciansFind out more at: thelancet.com/journals/lanres/article/PIIS2213-2600(22)00228-4/fulltext
Video Abstract | Digital Technology and the Future of Interstitial Lung Diseases The Lancet 2022-10-04 | Dr Marlies Wijsenbeek introduces the paper, Home monitoring in interstitial lung diseases, the first in the Series on Digital Technology and the Future of Interstitial Lung Diseases.Read the full paper at: thelancet.com/journals/lanres/article/PIIS2213-2600(22)00228-4/fulltext
Clinical Picture | Pleuro-peritoneal communication in a patient on dialysis The Lancet 2022-09-15 | Pleural effusion in patient on dialysis Read the full Clinical Picture, A sweet unilateral pleural effusion: pleuro-peritoneal communication in a patient on dialysis, at thelancet.com
Clinical Picture | A posterior inferior cerebellar artery aneurysm ruptures The Lancet 2022-09-08 | Subarachnoid haemorrhage and headache: rupture and rebleeding Read the full Clinical Picture, A posterior inferior cerebellar artery aneurysm ruptures during three-dimensional rotational angiography: need to think fast and act faster, at thelancet.com/journals/lancet/article/PIIS0140-6736(22)01387-3/fulltext
Clinical Picture | Nailing down a cause of cardiac failure in haemochromatosis The Lancet 2022-08-18 | Cardiac involvement in juvenile haemochromatosisRead the full Clinical Picture, A heart of iron: juvenile haemochromatosis presents with cardiac failure, at thelancet.com/journals/lancet/article/PIIS0140-6736(22)01285-5/fulltext
Clinical Picture | No clubbing in the fingers only in toes: severe pulmonary arterial hypertension The Lancet 2022-08-11 | Eisenmenger syndrome and patent ductus arteriosusRead the full Clinical Picture, No clubbing in the fingers, only in the toes: patent ductusarteriosus and reversed shunting at thelancet.com/journals/lancet/article/PIIS0140-6736(22)00792-9/fulltext
Clinical Picture | Giving a kidney and stem cells: brotherly love in end-stage renal failure The Lancet 2022-08-04 | Inducing immune tolerance for a brother giving a kidney and stem-cell transplantRead the full Clinical Picture, Immune tolerance induction through haematopoietic chimerism after kidney donation, at thelancet.com/journals/lancet/article/PIIS0140-6736(22)00914-X/fulltext
Clinical Picture | Looking of inconsistency and incongruence The Lancet 2022-07-21 | Functional movement disorder: not a diagnosis of exclusionRead the full Clinical Picture, Inconsistency and incongruence: the two diagnostic pillars of functional movement disorder, at thelancet.com/article/S0140-6736(22)01184-9/fulltext
Clinical Picture | Giant cell myocarditis presents with arrhythmias The Lancet 2022-06-14 | Diagnosing giant cell myocarditis needed an explanted heartRead the full Clinical Picture, Atypical arrhythmogenic presentation of giant cell myocarditis diagnosed after heart transplant, at thelancet.com/article/S0140-6736(22)00481-0/fulltext
Clinical Picture | Cerebellar hemangioblastoma & visual & sensory disturbances presenting postpartum The Lancet 2022-05-26 | Slowly developing cerebellar hemangioblastomaRead the full Clinical Picture, A cerebellar hemangioblastoma and visual and sensory disturbances presenting post partum, at thelancet.com/article/S0140-6736(22)00822-4/fulltext
Clinical Picture | Migrated mesh obscures malignancy The Lancet 2022-05-19 | Intraluminal mesh in the gut masks carcinomaRead the full Clinical Picture, Mesh migrations may mask malignancy: a patient with adenocarcinoma of the bowel, at thelancet.com/journals/lancet/article/PIIS0140-6736(22)00665-1/fulltext?rss=yes
Clinical Picture | DRESS syndrome and a positive Monospot test in a patient on lamotrigine The Lancet 2022-05-12 | DRESS syndrome, Ebstein-Barr virus infection, and lamotrigine Read the full Clinical Picture, Acute onset of fever, eosinophilia, rash, acute kidney injury, and a positive Monospot test in a patient on lamotrigine: DRESS syndrome, at thelancet.com/article/S0140-6736(22)00464-0/fulltext
Clinical Picture | Diabetes insipidus in pregnancy: need to exclude pre-eclampsia The Lancet 2022-05-05 | Pre-eclampsia with paradoxical polyuria: diabetes insipidus in pregnancyRead the full Clinical Picture, Pre-eclampsia with paradoxical polyuria: diabetes insipidus in pregnancy at thelancet.com/article/S0140-6736(22)00565-7/fulltext
Clinical Picture | Abdominal pain and recurrent vomiting: target sign on CT scan The Lancet 2022-03-24 | Don’t miss the target, doughnut, or bull’s eye sign indicating an intussusceptionRead the full Clinical Picture, Extraskeletal Ewing sarcoma of the duodenum presenting as duodenojejunal intussusception: thelancet.com/journals/lancet/article/PIIS0140-6736(22)00361-0/fulltext
Clinical Picture | Bones, moans, and abdominal groans in hyperparathyroidism The Lancet 2022-03-18 | Bones, moans, and abdominal groans in pseudohypoparathyroidism, hypoparathyroidism, and fibrous dysplasia. Different x-ray changes with increased cAMP signallingRead the full Clinical Picture, Calvarial hyperostosis in primary hyperparathyroidism and other settings of increased cAMP signalling: thelancet.com/article/S0140-6736(22)00149-0/fulltext
Clinical Picture | Antiphospholipid syndrome following Q fever The Lancet 2022-03-17 | Infective endocarditis and thromboses due to antiphospholipid syndrome following acute Q feverRead the full Clinical Picture, Infective endocarditis and thromboses due to antiphospholipid syndrome following acute Q fever at thelancet.com/journals/lancet/article/PIIS0140-6736(22)00376-2/fulltext
What is The Lancet? The Lancet 2022-03-17 | The Lancet has aimed to make science widely available so that medicine can serve and transform society, and positively impact the lives of people since 1823. Find out more at thelancet.comOver the past two centuries, The Lancet has sought to address urgent topics in our society, initiate debate, put science into context, and influence decision makers around the world.The Lancet has evolved as a family of journals but retains at its core the belief that medicine must serve society, that knowledge must transform society, that the best science must lead to better lives.
How to improve health in Nigeria | The Lancet Nigeria Commission The Lancet 2022-03-16 | Nigeria is rightly taking its place on the world stage. But its health has been neglected. Prof Iruka Okeke and Dr Ṣẹ̀yẹ Abímbọ́lá lay out a positive, achievable vision for a healthy future.Read the Lancet Nigeria Commission: investing in health and the future of the nation: thelancet.com/commissions/health-in-nigeria Nigeria is projected to become one of the most populous countries in the world, and is rightly taking its place on the world stage. The Lancet Nigeria Commission tells the story of the country through a health lens, and details recommendations that will enable the country and its people to fulfil their potential, and seize the opportunity ahead. It has been led by Nigerians for Nigerians. The Commissioners call for the creation of a new social contract that redefines the relationship between citizen and state. They argue that health has, to date, been neglected by successive governments and consequently the citizens of Nigeria, and must be recentred as a vital investment in the population – one that will reap political and economic benefits. Nigeria is poised to define the future of West Africa, the African continent, and the whole world. This Commission lays out how best to realise that ambition.Thanks toNigeria Health Watch nigeriahealthwatch.comInternational Rescue Committee: http://www.rescue-UK.org/uk-aid-matchAfrican Centre of Excellence for Genomics of Infectious Diseases (ACEGID) Olusegun Okanlawon Foundation olusegunokanlawonfoundation.orgAlpha Innovation Studio - alphainnovationstudio.comChudy OgobegwuLawal Ado Raphael Ajani Daniel Odeyemi Kunle IsholaBenedict AyoolaIyanuoluwa OyewaleACEGID - youtube.com/channel/UCdI3hw5j0Bu5laA9DSoLdFwYouTube channel 'UI Premier TV' University of Ibadan - youtube.com/channel/UCZW37piAx_KzO2LEoLm37CAMatteo Martino - youtube.com/user/MatteoMartinoYTVidevo - videvo.netPexels Gideon Hezekiah - pexels.com/@gideon-hezekiah-29104819/collectionsPexels Adedire Abiodun - pexels.com/photo/city-man-people-woman-10356870Pexels Samson Okeniyi - pexels.com/photo/woman-leaning-on-man-wearing-blue-crew-neck-shirt-3929522Uncoveredlens - pexels.com/photo/photo-of-man-bringing-radio-3620411Rodnae Productions from Pexels - pexels.com/@rodnae-prod 0:00 - One nation, one health1:00 - Health successes and challenges2:20 - Health is wealth3:20 - Embrace innovation4:50 - A social contract between citizens and government6:14 - An achievable health aspiration
Clinical Picture | Hearing but not understanding with a brainstem lesion The Lancet 2022-02-17 | Hearing problem that is not in the ear.Read the full paper, Hearing but not understanding: word deafness from a brainstem lesion, thelancet.com/journals/lancet/article/PIIS0140-6736(22)00191-X/fulltextFind out more at thelancet.com
A new vision for death and dying | The Lancet Commission on the Value of Death The Lancet 2022-01-31 | Read the Lancet Commission on the Value of Death: www.lancet.com/commissions/value-of-deathThe story of dying in the 21st century is a story of paradox. Covid-19 has meant people have died the ultimate medicalised deaths, often alone in hospitals with little communication with their families. But in other settings, including in some lower income countries, many people remain undertreated, dying of preventable conditions and without access to basic pain relief. The unbalanced and contradictory picture of death and dying is the basis for the Lancet Commission on the Value of Death. Drawing on multidisciplinary perspectives from around the globe, the Commissioners argue that death and life are bound together: without death there would be no life. The Commission proposes a new vision for death and dying, with greater community involvement alongside health and social care services, and increased bereavement support.Find out more at thelancet.comAdditional footage courtesy of:GreenAcres cemeteries and ceremonial parks greenacresgroup.co.ukAura Flights - ashesinspace.co.ukHippocratic feature film vimeo.com/ondemand/hippocraticRodnae Productions from Pexels - pexels.com/@rodnae-prodKampus Production from Pexels pexels.com/@kampus--00:00 - The paradox of 21st century dying01:55 A compassionate communities model in Kerala03:33 A realistic utopia05:16 What does it mean for you?
Clinical Picture | Loa loa shows itself after 6 years of hypereosinophilia The Lancet 2022-01-27 | Looking for Loa loaRead the full Clinical Picture in The Lancet: thelancet.com
Clinical Picture | Drugs causing sideroblastic anaemia: consider anti-tuberculosis medications The Lancet 2022-01-20 | Sideroblastic anaemia in patient with multidrug-resistant tuberculosisRead the full Clinical Picture, Seizures and sideroblastic anaemia in a patient with multidrug-resistant tuberculosis: thelancet.com/journals/lancet/article/PIIS0140-6736(22)00013-7/fulltext
Clinical Picture | Oncogenic NTRK fusion in congenital spinal cord glioblastoma The Lancet 2021-12-09 | Sequence and you may find oncogenic fusionsRead the full Clinical Picture, Oncogenic NTRK fusion in congenital spinal cord glioblastoma: sequencing directs treatment: thelancet.com/journals/lancet/article/PIIS0140-6736(21)02287-X/fulltext
Clinical Picture | Muckle Wells syndrome The Lancet 2021-12-02 | An autosomal dominant rare, auto-inflammatory disorder.Read the full Clinical Picture, Fever, abdominal pain, serositis, arthralgia, hearing loss, proteinuria, and a family history: Muckle Wells syndrome: thelancet.com/journals/lancet/article/PIIS0140-6736(21)02139-5/fulltext
How Global South researchers talk to the north | Whats wrong with global health? The Lancet 2021-12-02 | Do researchers from the Global South feel pressure to speak northern ideas, in northern language, to be heard and respected? Dr Thirusha Naidu explains the idea of ‘Northern ventriloquism’ and explores epistemic disobedience as a way to combat the problems it creates.Read Dr Naidu's essay, Says who? Northern ventriloquism, or epistemic disobedience in global health scholarship, in The Lancet Global Health: thelancet.com/journals/langlo/article/PIIS2214-109X(21)00198-4/fulltextExplore the full collection, What's wrong with global health: thelancet.com/collections/what-is-wrong-with-global-health?parent=01948300:00 - What is ‘Northern Ventriloquism’?01:22 - Epistemic disobedience to fight northern ventriloquism 03:13 - Flattening the power structures in global health04:51 – What is wrong with global health? Read more
Nourishing our future: Launch of the Lancet Series on Adolescent Nutrition The Lancet 2021-12-02 | Read the Lancet Series on Adolescent Nutrition: www.thelancet.com/series/adolescent-nutritionAdolescence brings phenomenal growth, transforming every physiological system. Yet, adolescent growth and nutrition has been largely overlooked. This Series synthesizes knowledge on the role of nutrition in adolescent growth, the drivers of adolescent food choice, and provides recommendations to reverse the trends and achieve better nutrition outcomes for this generation.At this global launch, authors present key findings and recommendations from the series, followed by a high-level panel discussion and audience Q&A.Find out more at www.thelancet.com/series/adolescent-nutrition
Youth voices on adolescent nutrition | The Lancet Series on Adolescent Nutrition The Lancet 2021-11-30 | Read the Lancet Series on Adolescent Nutrition: www.thelancet.com/series/adolescent-nutritionThe Series highlights the effect of nutrition on adolescent growth and development, the role the food environment has on food choices, and which strategies and interventions might lead to healthy adolescent nutrition and growth.Adolescence is a time of rapid changes in both physical growth and development and cognitive and emotional capacities. There rightly has been much emphasis on early childhood nutrition. However, adolescence is an additional important phase of risks and opportunities for healthy nutrition with lifelong and intergenerational consequences. Yet, this age group has been neglected in national and global plans and policies. Thanks to all the Youth Leaders that took part in this video, and Act4Food Act4Change. Find out more about them: actions4food.org/en/youth-leadersFind out more at thelancet.com
Clinical Picture | Uterine atrophy following chemotherapy in management of cervical cancer The Lancet 2021-11-25 | Uterine atrophy following chemotherapy in fertility sparing management of cervical cancerRead the full Clinical Picture, Unexplained uterine atrophy following neoadjuvant chemotherapy in fertility sparing management of cervical cancer, thelancet.com/journals/lancet/article/PIIS0140-6736(21)02253-4/fulltext
Clinical Picture | Hydroxychloroquine-induced cardiomyopathy precipitated by gastric banding The Lancet 2021-11-18 | Cardiomyopathy and hydroxychloroquine: accelerated after gastric bandingRead the full Clinical Picture, Hydroxychloroquine-induced cardiomyopathy accelerated after gastric banding: thelancet.com/journals/lancet/article/PIIS0140-6736(21)02177-2/fulltext
Clinical Picture | Psoriasis develops as an isomorphic response after skin graft The Lancet 2021-11-12 | Classic Koebner phenomenon with psoriasis after skin graftRead the full Clinical Picture, A pruritic psoriatic plaque develops at the donor site of an autologous skin graft: Koebner phenomenon, at thelancet.com/journals/lancet/article/PIIS0140-6736(21)02332-1/fulltext
Clinical Picture | High PSA with a large pelvic mass indicates a prostatic cystadenocarcinoma The Lancet 2021-11-04 | PSA and a large prostatic cystadenocarcinomaRead the full Clinical Picture. A high prostatic-specific antigen with a large pelvic mass indicates a prostatic cystadenocarcinoma: thelancet.com/journals/lancet/article/PIIS0140-6736(21)02174-7/fulltext
Clinical Picture | Pituitary apoplexy with a xanthogranuloma The Lancet 2021-10-28 | A xanthogranuloma rather than an adenoma presents with pituitary apoplexy.Read the full Clinical Picture: thelancet.com/journals/lancet/home
Global launch event | 2021 Lancet Countdown on health and climate change The Lancet 2021-10-27 | People in every region of the world are increasingly seeing their health affected by climate change. Key trends seen in previous Lancet Countdown Reports are getting worse and exacerbating already existing health and social inequities–the 2021 report gives a code red for health.Find out more at thelancet.com/countdown-health-climateChaired by Prof Anthony CostelloVideo message from Dr Tedros Adhanom Ghebreyesus, Director General of the WHOWelcome from Tamara Lucas, Executive Editor at the LancetVideo message from Rt Hon Helen Clark, Former Prime Minister of New ZealandKey findings of the report: Dr Marina Romanello, lead author and research director at the Lancet countdownHear from our regional centres:Dr Wenjia Cai, Professor for Earth System Science at Tsinghua University, China, Director of Lancet Countdown in AsiaDr Rachel Lowe, Associate Professor LSHTM, and Royal Society Dorothy Hodgkin Fellow, Director of Lancet Countdown in EuropeDr Stella Hartinger, Associate Professor at Cayetano Heredia University, Peru, and Co-Director of CLIMA, Director of Lancet Countdown in South AmericaDr Georgiana Gordon Strachan, Director, Tropical Metabolism Research Unit at the University of the West Indies and Director of Lancet Countdown in Small Island Developing StatesPanel discussion, and Q&A with: Almaaz Mudaly, High School Liaison of The National Youth Climate Action Plan at South African Institute of International Affairs (SAIIA)Sunita Narain, is Director General of the Centre for Science and Environment (CSE) and has been since 1982. She is a writer and environmentalist.Diarmid Campbell-Lendrum, Lancet Countdown Board Member and Head of WHO Climate Change Unit – currently taking part in the ride for their lives bike ride to COP26 from GenevaProf Elizabeth Robinson, Director, Grantham Research Institute on Climate Change and the Environment, Lancet Countdown Author and working group lead on climate change impacts, exposures, and vulnerabilitiesClosing words from:Dr Saleemul Huq, Director of the International Centre for Climate Change and Development (ICCCAD) in Bangladesh
Clinical Picture | Conservative management of perforated diverticulitis. The Lancet 2021-10-22 | Latest guidelines recommend non-invasive treatment of perforated diverticulitis.Reach the full Clinical Picture, Conservative treatment of perforated diverticulitis: following the latest guidelines pays dividends: thelancet.com/journals/lancet/article/PIIS0140-6736(21)02003-1/fulltext
Clinical Picture | Mitral valve disease in sarcoidosis diagnosed by cardiovascular MR The Lancet 2021-10-08 | Sarcoidosis and shortness of breath. Cardiovascular magnetic resonance shines a light on the mitral valveRead the full Clinical Picture, Mitral valve disease in sarcoidosis diagnosed by cardiovascular magnetic resonance: thelancet.com/journals/lancet/article/PIIS0140-6736(21)01791-8/fulltext
How to improve access to diagnostics for everyone | The Lancet Commission on diagnostics The Lancet 2021-10-06 | 10 recommendations on how to transform access to diagnostics around the world. Read the Lancet Commission on diagnostics: thelancet.com/commissions/diagnosticsDiagnostics are an essential part of a well functioning and high-quality health system. Yet, almost half of the global population has little or no access to diagnostics. The COVID-19 pandemic has shown acutely that diagnostic capacity in a country is directly linked to the ability to respond to the pandemic with appropriate public health measures and to monitor emerging variants. There is an urgent need to strengthen diagnostics for future pandemic preparedness but also beyond pandemics. Diagnostics are central to an accurate diagnosis of communicable and non-communicable diseases, to guide therapy, monitor progress, and assess response to treatment. The Commission puts forward recommendations to accelerate and transform access to diagnostics globally.Chinese, French, and Spanish subtitles available. Click the settings icon, and select your language under 'subtitles'.0:00 A lack of access around the world0:26 Searching for a solution1:06 Ten recommendations for change
Clinical Picture | Intestinal graft-versus-host disease The Lancet 2021-09-24 | Diagnosing intestinal graft-versus-host disease using ultrasonography Read the full Clinical Picture, Diagnosing acute intestinal graft-versus-host disease by a non-invasive method: transabdominal ultrasonography and colour doppler imaging, at thelancet.com/journals/lancet/article/PIIS0140-6736(21)01918-8/fulltext
Clinical Picture | Budd-Chiari syndrome complicates a case of paroxysmal nocturnal haemoglobinuria The Lancet 2021-09-15 | Paroxysmal nocturnal haemoglobinuria causes abdominal pain.Read the full Clinical Picture, Chronic Budd–Chiari syndrome in paroxysmal nocturnal haemoglobinuria, at thelancet.com/journals/lancet/article/PIIS0140-6736(21)01542-7/fulltext
Clinical Picture | Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome The Lancet 2021-08-13 | A newly-described auto-immune and myelodysplastic syndrome combination.Read the full Clinical Picture, Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome: fevers, myalgia, arthralgia, auricular chondritis, and erythema nodosum: thelancet.com/journals/lancet/article/PIIS0140-6736(21)01430-6/fulltext
