Combining CBG and Chemotherapy to Treat Pancreatic Cancer with Mandip Sachdeva, PhD @medicinal.genomics

Uploaded January 2026 | Updated September 2026, 2 weeks ago

Dr. Mandip Sachdeva is currently a Professor and Section leader, Pharmaceutics at College of Pharmacy at Florida A & M University (FAMU), Tallahassee, Florida. Over his career, Mandip has delivered more than 250 plenaries, keynote and invited talks in international events and meetings and produced more than 190 original publications.His research interests include cancer drug delivery, 3D-printing of tumor cells, and formulating and developing targeted nanoparticles, exosomes and cannabinoids for cancer treatments.

During our conversation, Mandip previews his CannMed 26 oral presentation titled, “Cannabigerol Potentiates Chemotherapy through Multi-Modal Tumor Suppression in Pancreatic Cancer“, which includes insights into his research on using cannabinoids (particularly CBG) to treat pancreatic cancer—one of the most difficult cancers to treat. We cover:

- The process Mandip’s team used to determine CBG had the best anti-cancer effects against pancreatic cancer
- CBG’s mechanism of action, which targets multiple pathways related to immune regulation, cell death, and tumor migration control
- Why cannabinoids are best used as adjuncts to chemotherapy and not as a standalone treatment
- Higher doses of CBG (up to 100 mg/kg) were non-toxic and further extended survival when combined with reduced chemo doses
- Future research directions, including new combinations of cannabinoids and chemotherapy as well as new formulations for better absorption and bioavailability

Thanks to This Episode’s Sponsor: Healer

Healer is a trusted, physician-developed medical cannabis brand founded to address the challenges of helping patients and health providers get the best results with safe, reliably dosable products and education on how to best use them. Healer’s distinctive product formulations and educational material are based on the work of leading cannabis clinician, Dr. Dustin Sulak, D.O.

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Additional Resources
- Register for CannMed 26 - cvent.me/ROOWel
- Sachdeva Laboratory - https://pharmacy.famu.edu/research/research_laboratories/sachdeva-laboratory/index.php

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$Temperature-Controlled n-Butane Extraction Minimizes Waxes While Preserving Cannabinoids and VOCs Manuel Sosa presents Temperature-Controlled n-Butane Extraction Minimizes Waxes While Preserving Cannabinoids and VOCs at CannMed 2026, covering n-butane extraction, cannabis waxes, and cannabinoid preservation. Cannabis produces a broad range of desirable nonpolar constituents, including cannabinoids and volatile organic compounds (VOCs), making nonpolar solvents such as n-butane well suited for extracting and formulating cannabis oils. However, a poorly characterized nonpolar fraction commonly referred to as fats and waxes is often co-extracted, leading to cloudiness and the need for downstream winterization. The objective of this study was to determine how extraction temperature affects the co-extraction of waxes and their transfer to the aerosol phase, while maintaining recovery of cannabinoids and VOCs. Two commercial cannabis varieties were extracted with n-butane at multiple jacket temperatures spanning sub-zero to near-ambient conditions. Crude extracts were characterized for cannabinoids and VOCs by chromatographic methods, and the nonpolar background was profiled with a focus on long-chain alkanes associated with epicuticular wax. Viscosity was measured to assess potential effects on vape-device performance, and vaping experiments with cartridge-style hardware were used to quantify transfer of these waxes into the inhalable aerosol. We found that saturated n-alkanes characteristic of plant waxes were major components of the co-extracted nonpolar fraction and increased systematically with extraction temperature, whereas concentrations of target cannabinoids and VOCs remained comparatively stable over the same range. Bulk viscosity changed only modestly with composition, but the waxes readily transferred into the aerosol, with lower transfer observed when extraction temperature was reduced. We conclude that temperature control during n-butane extraction is a practical process lever to limit co-extraction and aerosolization of waxes while preserving key cannabinoids and VOCs, thereby improving concentrate purity and inhalation safety. Learning Objectives: ⦿ How n-butane extraction temperature changes co-extraction of epicuticular waxes in cannabis oils ⦿ Why cannabinoid and VOC yields stay relatively stable across temperatures ⦿ How lowering temperature reduces wax in the aerosol phase Manuel Sosa is an R&D Chemist II and Lab Supervisor at Abstrax Tech, where his team leads analytical testing and research through advanced techniques such as 2D GCxGC and HPLC. His role involves conducting rigorous tests as well as developing and refining standard operating procedures to improve the labs precision and efficiency, alongside publishing scientific research and developing new intellectual property for the company. This presentation was given at the CannMed 2026 Innovation & Collaboration Summit, held June 15-18 at the Hyatt Regency Lake Tahoe Resort. Visit cannmedevents.com to learn more.$

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