Amazing footage of how falcons catch their prey. The Company of Biologists 2024-10-18 | Amazing footage of how falcons catch their prey.
Development Presents... Elena Camacho Aguilar The Company of Biologists 2023-06-09 | On 31 May 2023, Development hosted a webinar on the topic of in vitro and stem cell-based models of development.Elena Camacho Aguilar from Rice University talked about ‘Combinatorial integration of BMP and WNT allows BMP to act as a morphogen in time but not in concentration’.For more information about the Development presents... webinar series thenode.biologists.com/devpres
Development Presents... Tyler Huycke The Company of Biologists 2023-06-09 | On 31 May 2023, Development hosted a webinar on the topic of in vitro and stem cell-based models of development.Tyler Huycke from University of California, San Francisco (UCSF) talked about ‘Patterning and folding of intestinal villi by active mesenchymal dewetting’.For more information about the Development presents... webinar series thenode.biologists.com/devpres
Development Presents... Anchel de Jaime Soguero The Company of Biologists 2023-06-09 | On 31 May 2023, Development hosted a webinar on the topic of in vitro and stem cell-based models of development.Anchel de Jaime Soguero from COS, University of Heidelberg talked about ‘Cell signaling control of genome stability during early lineage'.For more information about the Development presents... webinar series thenode.biologists.com/devpres
Neutrophil supplemental video 1 540p 1 The Company of Biologists 2023-06-08 | Differentially stained neutrophils moving through a microfluidic device. Part A shows cells only, and Part B shows coded cell tracks. See article by Shen et al. at doi.org/10/1242/jcs.260768.
Migration of adult fat body precursor cells in the fly abdomen The Company of Biologists 2023-05-25 | In Volume 150, Issue 10, Taiichi Tsuyama, Tadashi Uemura and colleagues identify the origins and developmental processes of adult-type fat body in Drosophila.This video shows that adult fat body precursor cells (AFBp) in fruit flies migrate dorsally in the fly abdomen. Until 30 h APF, AFBp cells were only seen at the ventral side of the abdomen and migrated in the posterior direction. After 30 h APF, a subset of these cells started moving dorsally and covered almost the entire areas of the pleurite and tergite. Anterior is to the left, and dorsal is up.
Time-lapse microscopy of a scale injury in adult zebrafish. The Company of Biologists 2023-05-11 | Individual scales of adult zebrafish were snipped with micro scissors, causing widespread damage in the epidermis and Wallerian degeneration. Degeneration of axons (magenta) was observed 2-4 h after injury, and mpeg1+ Langerhans cells (cyan) were then observed engulfing axonal debris. Scale bar: 100 μm.For more details, see the complete article by Peterman et al. (doi.org/10/1242/dmm.049911).
Why propose a topic for one of our Workshops? The Company of Biologists 2023-05-09 | Getting involved as an organiser for one of our Workshops is easy. We focus on the logistics, so you can focus solely on the science. Are you thinking about proposing a topic for one of our Workshops? Watch this video to hear from some of our previous organisers.Find out more at biologists.com/workshops/propose-new-workshop
Unipotent progenitors (UHCP) dividing into two hair cells. The Company of Biologists 2023-05-05 | In Volume 150, Issue 9 of Development, Eva L. Kozak, Jerónimo R. Miranda-Rodríguez, Hernán López-Schier and colleagues uncovers a role for Notch1a-mediated symmetry breaking in stabilising cell rotation.This highlighted video shows a wild-type horizontal neuromast with a focus on a dividing UHCP that results in a pair of nascent hair cells inverting. Membranes are marked by the claudnb:lyn-EGFP transgenic. Hair cells are marked simultaneously by myo6b:β-actin-GFP that also allows us to see the orientation of their hair bundle.
Development Presents... Morris Maduro The Company of Biologists 2023-05-05 | On Wednesday 19 April 2023, Development hosted a webinar that celebrates the finalists for Development’s Inaugural Outstanding Paper Prize and was chaired by Deputy Editor, Steve Wilson (UCL).Morris Maduro (University of California) talked about 'The GATA factor ELT-3 specifies endoderm in Caenorhabditis angaria in an ancestral gene network’. The talk was followed by a live Q&A with Morris.Research article: journals.biologists.com/dev/article/149/21/dev200984/278466/The-GATA-factor-ELT-3-specifies-endoderm-inMore on Development's Inaugural Outstanding Paper Prize: journals.biologists.com/dev/article/150/7/dev201810/306247/Development-s-Inaugural-Outstanding-Paper-PrizeFor more information about the Development presents... webinar series thenode.biologists.com/devpres
Development Presents... Jürgen Kleine Vehn The Company of Biologists 2023-05-05 | On Wednesday 19 April 2023, Development hosted a webinar that celebrates the finalists for Development’s Inaugural Outstanding Paper Prize and was chaired by Deputy Editor, Steve Wilson (UCL).Jürgen Kleine-Vehn (Institute of Molecular Plant Biology) talked about PILS proteins providing a homeostatic feedback on auxin signaling output. The talk was followed by a live Q&A with Jürgen.Research article: journals.biologists.com/dev/article/149/13/dev200929/275949/PILS-proteins-provide-a-homeostatic-feedback-onMore on Development's Inaugural Outstanding Paper Prize: journals.biologists.com/dev/article/150/7/dev201810/306247/Development-s-Inaugural-Outstanding-Paper-PrizeFor more information about the Development presents... webinar series thenode.biologists.com/devpres
preLights’ 5th Birthday webinar: A career discussion with preLights alumni The Company of Biologists 2023-03-15 | preLights is celebrating its 5th birthday. To mark the occasion, this webinar features four short talks given by preLights alumni who have all made significant contributions to preLights, and have since taken a range of career paths. In their talks, they tell us how they have managed to identify and navigate the challenges, opportunities, and obstacles they faced as early-career researchers and how this has all led them to where they are today. Also, they tell us a bit about their current position and future goals and ambitions.Discussion moderator: Reinier Prosée, preLights Community Manager, The Company of Biologists.Speakers:• Martin Balcerowicz, Principal Investigator, University of Dundee, UK• Sejal Davla, Freelance Science Writer and Data Consultant, Canada• Amanda Haage, Assistant Professor, University of North Dakota, USA• Sagar Varankar, Senior Scientist, HigherSteaks, UK• Q&A (~20 minutes)
What is the best thing preLights offers the biological community? The Company of Biologists 2023-02-28 | To celebrate preLights 5th birthday, we’ve asked preLighters what they think is the best thing preLights offers the biological community. This video bundles together some of the lovely responses we’ve received.Special thanks to Angika Basant, Divya Pathak, Kanika Khanna, Jade Chan, Ethan Ewe, Saanjbati Adhikari, Giuliana Clemente, Laura Celotto & Juan Moriano!
Webinar: Increasing the visibility and impact of your research The Company of Biologists 2023-02-28 | In this very popular and highly practical 90-minute webinar that we co-hosted with HUBS (Heads of Universities Biosciences) on 23 February 2023, expert speakers from across the scholarly community demonstrated and discussed ways in which researchers can increase the visibility and impact of their research and raise their profile internationally.The webinar was chaired by Malavika Legge, Program Manager, Open Access Scholarly Publishing Association (OASPA).Speakers: • Reaching your audience: How to tell your story and how to choose the right journalKatherine Brown, Executive Editor, Development, The Company of Biologists• The importance of preprints: How is the use of preprints evolving? What are the latest initiatives? How do authors benefit from preprinting?Theo Bloom, Executive Editor, The BMJ and Co-Founder, medRxiv• Transitioning to Open Access: How does Open Access publishing benefit authors? What can we learn from comparative metrics? How are new initiatives transforming journals as they move towards greater OA content?Claire Moulton, Publisher, The Company of Biologists• The institutional perspective: What do institutions consider important regarding journal choice, Open Access, data deposition, and claiming the publication? What resources and expertise might be available for scholarly communications and post publication engagement?Steven Vidovic, Head of Open Research & Publication Practice, Library, University of SouthamptonFor more information on Read & Publish for researchers, visit biologists.com/library-hub/read-publish/researchersFor more information on HUBS, visit rsb.org.uk/education/hubs
F-actin and Myosin II transiently accumulate at cell junctions along the forming AP boundary The Company of Biologists 2023-02-24 | Time-lapse movies of histoblasts expressing fluorescent markers for F-actin (left) and Myosin II (right) in the pupal abdominal epidermis in Drosophila. Myosin II rapidly and transiently accumulates at newly forming cell junctions along the forming anterioposterior (AP) compartment boundary. Scale bar: 20 μm.See the complete article by Wang et al. at doi.org/10/1242/jcs.260447.
Five years of preLights: an early career researcher-led preprint highlighting service The Company of Biologists 2023-02-20 | preLights, the preprint highlighting service run by the biological community and supported by The Company of Biologists, was launched in 2018. This video summarises the way in which preLights works and highlights some important milestones since its launch five years ago. For more, please check out our website: prelights.biologists.com
Development presents... Kirsten ten Tusscher The Company of Biologists 2023-02-07 | On Wednesday 25 January, Development hosted three talks on the topic of theoretical and computational modelling of development and stem cells.The final talk came from Kirsten ten Tusscher (Professor of Computational Developmental Biology at Utrecht University) who presented ‘Reverse engineering lateral root formation’The talk is followed by a Q&A with Kirsten, chaired by Associate Editor Paul François.For more details, check out their paper published in Developmentjournals.biologists.com/dev/article/149/22/dev200927/283180/Complementary-roles-for-auxin-and-auxin-signallingFor more information about the Development presents... webinar series thenode.biologists.com/devpres
Development presents... Mindy Liu Perkins The Company of Biologists 2023-02-07 | On Wednesday 25 January, Development hosted three talks on the topic of theoretical and computational modelling of development and stem cells.The second talk came from Mindy Liu Perkins (Postdoctoral Fellow in Justin Crocker‘s lab at EMBL presenting work from Hernan Garcia's lab) who presented ‘A bistable autoregulatory module in the developing embryo commits cells to binary fates’The talk is followed by a Q&A with Mindy, chaired by Associate Editor Paul François.For more details, check out their preprint:biorxiv.org/content/10.1101/2022.10.31.514335v1For more information about the Development presents... webinar series thenode.biologists.com/devpres
Development presents... Simon Freedman The Company of Biologists 2023-02-07 | On Wednesday 25 January, Development hosted three talks on the topic of theoretical and computational modelling of development and stem cells.The first talk came from Simon Freedman (Senior Bioinformatics Scientist at Illumina presenting Postdoctoral work from Madhav Mani‘s group at Northwestern University) who presented ‘A dynamical systems approach to cell fate decisions’.The talk is followed by a Q&A with Simon, chaired by Associate Editor Paul François.For more details, check out their preprint:biorxiv.org/content/10.1101/2021.05.03.442465v2For more information about the Development presents... webinar series thenode.biologists.com/devpres
Dynamics of cGMPi in the late-aggregation stage Dictyostelium cells The Company of Biologists 2023-02-02 | Cells turned around the center, and fluorescence propagated outward in a spiral or concentric pattern, turning around the center in the opposite direction. See article by S. Yumura et. al. at doi.org/10.1242/jcs. 260591.
Knockdown of Src42A affects the speed of germband extension. The Company of Biologists 2023-01-31 | In Issue 2, Lenin Chandran, Stefan Luschnig, H.-Arno Müller and colleagues show that Src42A is required for E-cadherin dynamics during axis elongation. The highlighted movie is of germband extension in control (upper) and Src42A knockdown (lower) embryos. Time is indicated in mm:ss format.
The Company of Biologists Workshops - Developmental Metabolism and the Origins of Health and Disease The Company of Biologists 2023-01-31 | The Company of Biologists Workshop 'Developmental Metabolism and the Origins of Health and Disease' took place at Buxted Park, East Sussex, UK on 24 - 27 October 2022 and was organised by Sally Dunwoodie and Alex Gould.We offer funded places for early-career researchers. Find out more about our Workshops and the latest deadlines to apply for your place: http://www.biologists.com/workshops
Imaging of ptpn6-/- mutant 4dpf embryos in tg(mpx:GFP/mpeg:mCherry)background The Company of Biologists 2023-01-30 | Neutrophils are shown in green and macrophages in red. Embryos were anesthesized with tricaine and tails were transsected distal to the notochord by scalpel blade. Embryos were mounted immediately for confocal imaging and imaged every minute from ~30 min post amputation onwards for 7 h. Representative movie is shown.
3D rendering of endothelial cells in the brain of an adult transgenic D. cerebrum The Company of Biologists 2023-01-05 | The z-stack images of the Tg(kdrl:mCherry-caax) transgenic fish with fluorescent endothelial cells used to generate Figure 2F were processed into a 3D rendered movie. Colours are assigned based on the depth as indicated in the scale.
Cytoplasmic movement in an Mnanog embryo The Company of Biologists 2022-12-21 | In Issue 24, Mudan He, Shengbo Jiao, Yonghua Sun and colleagues highlight the role of maternal Nanog in translational control of maternal mRNA during oogenesis and early embryogenesis. The highlighted movie shows cytoplasmic movement in a Mnanog mutant embryo.
Development presents... Benjamin Jackson The Company of Biologists 2022-12-20 | On Wednesday 7 December, Development hosted three talks on metabolic and nutritional control of development and regeneration, the topic of our upcoming Special Issue. The webinar was chaired by Irene Miguel-Aliaga (Imperial College London and MRC-LMS, UK), who will be editing the special issue alongside Lydia Finley (Memorial Sloan Kettering Cancer Center, USA), Joshua Gendron (Yale University, USA) and Jared Rutter (University of Utah, USA).The third talk came from Benjamin Jackson (MD-PhD Candidate in Lydia Finley‘s group at Memorial Sloan Kettering Cancer Center), on a non-canonical TCA cycle that underlies cell identity. The talk is followed by a live Q&A with Benjamin, chaired by Irene.Full research article: nature.com/articles/s41586-022-04475-wFor our upcoming Special Issue: journals.biologists.com/dev/pages/metabolismFor more information about the Development presents... webinar series thenode.biologists.com/devpres
Development presents... Hannah Brunsdon The Company of Biologists 2022-12-20 | On Wednesday 7 December, Development hosted three talks on metabolic and nutritional control of development and regeneration, the topic of our upcoming Special Issue. The webinar was chaired by Irene Miguel-Aliaga (Imperial College London and MRC-LMS, UK), who will be editing the special issue alongside Lydia Finley (Memorial Sloan Kettering Cancer Center, USA), Joshua Gendron (Yale University, USA) and Jared Rutter (University of Utah, USA).The second talk came from Hannah Brunsdon (Postdoctoral Research Fellow in Liz Patton’s group at the IGC, University of Edinburgh), on the role of Aldh2 as a metabolic gatekeeper during melanocyte regeneration in zebrafish. The talk is followed by a live Q&A with Hannah, chaired by Irene.Research article: journals.biologists.com/dev/article/149/10/dev200277/275458/Aldh2-is-a-lineage-specific-metabolic-gatekeeperFor our upcoming Special Issue: journals.biologists.com/dev/pages/metabolismFor more information about the Development presents... webinar series thenode.biologists.com/devpres
Development presents... Natalia López Anguita The Company of Biologists 2022-12-20 | On Wednesday 7 December, Development hosted three talks on metabolic and nutritional control of development and regeneration, the topic of our upcoming Special Issue. The webinar was chaired by Irene Miguel-Aliaga (Imperial College London and MRC-LMS, UK), who will be editing the special issue alongside Lydia Finley (Memorial Sloan Kettering Cancer Center, USA), Joshua Gendron (Yale University, USA) and Jared Rutter (University of Utah, USA).The first talk came from Natalia López Anguita (PhD student in the Stem Cell Chromatin Group at the Max Planck Institute for Molecular Genetics), who discussed how hypoxia affects pluripotent cells during gastruloid formation. The talk is followed by a live Q&A with Natalia, chaired by Irene.Research article: journals.biologists.com/dev/article/149/20/dev200679/276626/Hypoxia-induces-an-early-primitive-streakFor our upcoming Special Issue: journals.biologists.com/dev/pages/metabolismFor more information about the Development presents... webinar series thenode.biologists.com/devpres
Pre- and postsynaptic structures in a 14-month-old brain organoid The Company of Biologists 2022-11-25 | In our Special Issue: Modelling Development In Vitro, Juan Eduardo Rodriguez-Gatica, Vira Iefremova, Oliver Brüstle, Martin Karl Schwarz, Ulrich Kubitscheck and colleagues introduce their system to combine tissue expansion and light-sheet fluorescence microscopy for imaging organoid development. The highlighted movie shows pre- and postsynaptic structures in a 14-month-old brain organoid, labelled with synapsin 1 and Homer1.journals.biologists.com/dev/article/149/20/dev200439/276224/Imaging-three-dimensional-brain-organoid
Segmentation of an extracellular vesicular structure connected to inner segment mitochondrion The Company of Biologists 2022-11-25 | Tomogram segmentation of an extracellular vesicular structure connected to inner segment mitochondrion through a complex membrane tunnel. See article by Lewis et al. doi.org/10.1242/dmm.049871
Ultrastructure expansion microscopy of expanded Toxoplasma gondii parasites undergoing division The Company of Biologists 2022-11-15 | Full Z-stacking of expanded parasites undergoing division during an early stage. The outer mitochondrial membrane-associated protein LMF1 and the inner membrane complex (IMC) interact during mitochondrial distribution. The IMC is represented in magenta, LMF1 in yellow. See article by R. O. Oliveira Souza at doi.org/10.1242/jcs.260083.
The Company of Biologists Workshops - From Physics to Function The Company of Biologists 2022-11-10 | The Company of Biologists Workshop 'From Physics to Function' took place at Buxted Park, East Sussex, UK on 9 - 12 October 2022 and was organised by Johanna Ivaska and Xavier TrepatWe offer funded places for early-career researchers. Find out more about our Workshops and the latest deadlines to apply for your place: http://www.biologists.com/workshops
Development presents... Sham Tlili The Company of Biologists 2022-10-20 | On Tuesday 11 October, Development hosted three talks on the topic of our latest Special Issue, modelling development in vitro, chaired by Matthias Lutolf. The third talk came from Sham Tlili (CNRS research investigator at the Marseille Developmental Biology Institute (IBDM) in Aix-Marseille University), who discussed the use of their microfluidic platform to investigate the role of mechanics in tissue reorganisation. The talk is followed by a live Q&A with Sham, chaired by Matthias.For more details, check out their paper published in Development journals.biologists.com/dev/article/doi/10.1242/dev.200774/276846/A-microfluidic-platform-to-investigate-the-role-ofFor our Special Issue: Modelling Development In Vitro journals.biologists.com/dev/issue/149/20For more information about the Development presents... webinar series thenode.biologists.com/devpres
Development presents... Ansley Conchola The Company of Biologists 2022-10-20 | On Tuesday 11 October, Development hosted three talks on the topic of our latest Special Issue, modelling development in vitro, chaired by Matthias Lutolf. The second talk came from Ansley Conchola (MSTP MD/PhD candidate in Jason Spence‘s lab at the University of Michigan Medical School), who presented their work on establishing and characterising stable iPSC-derived NKX2-1+ lung bud tip progenitor organoids. The talk is followed by a live Q&A with Ansley, chaired by Matthias.For more details, check out their paper published in Development journals.biologists.com/dev/article/149/20/dev200693/276470/Stable-iPSC-derived-NKX2-1-lung-bud-tip-progenitorFor our Special Issue: Modelling Development In Vitro journals.biologists.com/dev/issue/149/20For more information about the Development presents... webinar series thenode.biologists.com/devpres
Development presents... Alexandra Wehmeyer and Sebastian Arnold The Company of Biologists 2022-10-20 | On Tuesday 11 October, Development hosted three talks on the topic of our latest Special Issue on modelling development in vitro, chaired by Matthias Lutolf. The first talk came from Alexandra Wehmeyer (M.D. thesis student) and Sebastian Arnold (Acting Director, Institute of Pharmacology, University of Freiburg), who presented their chimeric 3D gastruloid models as tools for studying peri-gastrulation in mammals. The talk is followed by a live Q&A with Alexandra and Sebastian, chaired by Matthias.For our Special Issue: Modelling Development In Vitro journals.biologists.com/dev/issue/149/20For more information about the Development presents... webinar series thenode.biologists.com/devpres
Development presents... Technical, ethical and legal challenges of studying early human development The Company of Biologists 2022-10-19 | On Monday 12 September, we livestreamed a session from our meeting ‘From Stem Cells to Human Development’, as part of our Development presents… webinar series. We concluded the session with a panel discussion on technical, ethical and legal challenges of studying early human development. The panel included Amander Clark, Robin Lovell-Badge, Sergiu Pasca, Sarah Teichmann and Magdalena Zernicka-Goetz and the discussion was chaired by Patrick Tam.
Development presents... Sergiu Pasca The Company of Biologists 2022-10-19 | On Monday 12 September, we livestreamed a session from our meeting ‘From Stem Cells to Human Development’, as part of our Development presents… webinar series.The second talk came from Sergiu Pasca (Stanford University, USA) on ‘From stem cells to assembloids: constructing and deconstructing human nervous system development and disease’.The talk is followed by a Q&A with Sergiu, chaired by Patrick Tam. For more information about the Development presents... webinar series go to: thenode.biologists.com/devpres
Development presents... Sarah Teichmann The Company of Biologists 2022-10-19 | On Monday 12 September, we livestreamed a session from our meeting ‘From Stem Cells to Human Development’, as part of our Development presents… webinar series.The first talk came from Sarah Teichmann (Wellcome Sanger Institute, UK) on ‘Human development: one cell at a time’.The talk is followed by a Q&A with Sarah, chaired by Patrick Tam. For more information about the Development presents... webinar series go to: thenode.biologists.com/devpres
3D reconstruction of valve cells and valvosome from 700nm semi-thin sections The Company of Biologists 2022-10-12 | In Issue 19, Christian Meyer, Achim Paululat and colleagues examine the biosynthesis of the valvosome, a vesicular compartment found in cardiac valve cells. They use serial block-face electron microscopy to reconstruct a 3D model of cardiac valve cells and find that the valvosomes are interconnected, forming one large compartment that is continuous with the plasma membrane.
The Company of Biologists Workshops - The Biology and Physics of Left-Right Patterning The Company of Biologists 2022-10-07 | The Company of Biologists Workshop 'The Biology and Physics of Left-Right Patterning' took place at Buxted Park, East Sussex, UK on 5–8 June 2022 and was organised by Gonca Erdemci-Tandogan and Daniel Grimes. We offer funded places for early-career researchers. Find out more about our Workshops and the latest deadlines to apply for your place: http://www.biologists.com/workshops
Microtubule-based transport of intracellular virion particles The Company of Biologists 2022-10-04 | Intracellular viruses recruit kinesin-1 to undergo microtubule-dependent transport from their perinuclear site of assembly to the plasma membrane. This video shows intracellular viruses labelled with RFP-A3 (magenta) and A36-YdF-YFP (green) moving on GMPCPP-stabilised microtubules (blue) in vitro in the presence of ATP (left panels) but not AMPPNP (right panels). Scale bar: 5 μm.See the complete article by Xu et al. at doi.org/10/1242/jcs.260175.
Terrestrial locomotion video of an adult California sea lion The Company of Biologists 2022-09-26 | Anatomical points of reference show oscillatory patterns during the movement cycle.The original research can be accessed at doi.org/10.1242/jeb.244163
Zebrafish adult liver lobe imaged using FRaeppli and tissue clearing The Company of Biologists 2022-09-16 | In Issue 16, Sara Caviglia, Iris Unterweger, Elke Ober and colleagues present FRaeppli, a toolbox for multispectral cell tracing and dense tissue analysis in zebrafish. Our featured movie compares fluorescence signal between a cleared and uncleared adult liver lobe, where endogenous FRaeppli-NLS fluorescence signal is still detectable more than 120µm into the cleared liver lobe.
Rotational views through Fn1 and the extracellular matrix The Company of Biologists 2022-08-25 | Staining wild-type mouse embryos with saturating amounts of anti-Fn1 antibodies revealed that Fn1 fibrils in the pharyngeal arches and the heart appeared dotted, with regularly spaced regions of high and low fluorescence intensity. The dotted appearance of Fn1 fibrils in embryonic tissues suggests that the distribution of Fn1 molecules in Fn1 fibrils is not homogenous. Arrows point to examples of beaded Fn1 fibrils.See the complete article by Tomer et al. at doi.org/10.1242/jcs.260120.
Oscillatory Notch signalling during somite boundary formation, imaged using SPIM The Company of Biologists 2022-08-09 | In Issue 13, Henning J. Falk, Takehito Tomita, Alexander Aulehla and colleagues simultaneously image up to four mouse embryos using selective plane illumination microscopy (SPIM-for-4) to examine the oscillatory signalling dynamics from early gastrulation to somitogenesis. In our featured movie, the embryo is expressing the Notch signalling reporter LuVeLu (cyan) and R26H2Bmcherry to mark nuclei (red), and is imaged from the late allantois bud stage onwards.
Another Week, Another Transformative Open Access Agreement. But how transformative are they? The Company of Biologists 2022-07-15 | Transformative Open Access agreements between libraries and publishers are making waves around the world, opening up exciting new opportunities for researchers and authors. But are they transforming Open Access publishing?In this session, recorded for NASIG 37th Annual Conference, 5-8 June 2022, an expert panel explores librarian and publisher perspectives, drawing on the latest quantitative and qualitative data to demonstrate the impact that transformative agreements are having in practice – for institutions and their authors - and to provide important insight into future trends. The group will also discuss the challenges they have faced along the way plus opportunities for ongoing collaboration between publishers and libraries to accelerate a sustainable transition towards OA.The library perspective: Judith Russell is Dean of Libraries at the University of Florida. Over the past 18 months, the university library has signed a number of transformative Open Access agreements with a wide range of publishers – from small not-for-profit publishers to large commercial publishers. Following an overview of the key drivers and considerations in negotiating transformative agreements, Judith will present data showing the impact they have had on OA publishing by University of Florida authors and the feedback received from her research community. She will also discuss how financing and administering transformative agreements have created both challenges and opportunities for her library.The library consortia perspective: Ellen Finnie, Director of Shared Collections at the California Digital Library, will share insights into the University of California’s experience to date in negotiating transformative agreements - with publishers both large and small - on behalf of all ten University of California campuses. What has UC been learning? What have the challenges been? What is the role of a consortial approach in advancing the full range of stakeholders towards supporting Open Access?·The publisher perspective: Claire Moulton is Publisher at The Company of Biologists, one of the first not-for-profit publishers to launch a cost-neutral Read & Publish initiative, and publisher of the first journals in the world to be afforded Transformative Journal status by Plan S. Claire will share unique longitudinal data demonstrating the dramatic impact that these initiatives have had on OA publishing in The Company’s hybrid journals. She will also present the latest comparative metrics showing the author benefits of publishing OA versus non-OA articles.
Non-fusing mating pairs expressing Fus1N-Cdc12C fail to coalesce their actin fusion foci in S. pombe The Company of Biologists 2022-07-08 | Time lapse images starting ~4 h post starvation of homothallic strains expressing the formin chimera Fus1N-Cdc12C (green) and Myo52-tdTomato (magenta). The movie shows three successful fusion events and one unsuccessful fusion (black arrowhead), in which the two partner cells form distant fusion foci (white arrowhead). Scale bar: 5 μm.See the complete article by Billault-Chaumartin et al. at doi.org/10.1242/jcs.260289.
Time-lapse imaging of cell-cell interactions detected using SyNPL The Company of Biologists 2022-07-07 | In Issue 12, Mattias Malaguti, Sally Lowell and colleagues introduce SyNPL, pluripotent stem cell lines that use optimised ‘Synthetic Notch’ technology to detect cell-cell interaction between sender and receiver cells, both in culture and in chimaeric mouse embryos. Our featured movie is of CmGP1GH1 sender cells (green) and STC clone A1 receiver cells (red) imaged every 10 minutes for 24 hours.
Flowtrace movie of beads flowing past epidermis in control Xenopus embryos The Company of Biologists 2022-06-30 | Frame rate of 80 frames/second.
What happens when you preprint your paper? A primer. The Company of Biologists 2022-06-29 | Haven’t preprinted a paper before and wondering what you can expect? We run through the process for you, explaining all the steps, and discuss what future initiatives might bring to the preprint space.
Z-stack through mouse kidney expressing activated NOTCH The Company of Biologists 2022-06-14 | In Issue 10, Kathryn Duvall, Raphael Kopan and colleagues examine the role of Notch in nephron segmentation using the developing mouse kidney and human kidney organoids. Our featured movie is a Z-stack through a mouse kidney expressing activated NOTCH; labelled with antibodies against Wt1 (NPC and podocyte marker), Tfap2b (distal tubule marker) and Hnf4a and LTL (proximal tubule markers).journals.biologists.com/dev/article/149/10/dev200446/275412/Revisiting-the-role-of-Notch-in-nephronjournals.biologists.com/dev/issue/149/10
