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In this episode of The Silicon Fox Podcast, we sit down with Justin Li, CEO of Qore Performance, to ask why thermoregulation, the single biggest limiter of human performance, is still an afterthought for most athletes and operators. We discuss why core body temperature dictates everything from endurance to decision-making, what dehydration is actually doing to your blood volume and cognitive output, and how Qore is building cooling and hydration systems trusted by special operations forces and elite endurance athletes. We also get into why managing heat is the most overlooked variable in the wearable and performance optimization space.
A direct, gear-tested conversation about the physiology most people ignore until it shuts them down.
Qore Performance: How managing body temp impacts endurance, cognition, and output w/Justin LiThe Silicon Fox Podcast with Mitchell Leshchiner2026-04-09 | Sponsors: Check out the Qore Performance × Electrokare partnership and get your bundle now → electrokare.com
Fuel performance with Momentous. Use code "Siliconfox" for up to 35% off → livemomentous.com
In this episode of The Silicon Fox Podcast, we sit down with Justin Li, CEO of Qore Performance, to ask why thermoregulation, the single biggest limiter of human performance, is still an afterthought for most athletes and operators. We discuss why core body temperature dictates everything from endurance to decision-making, what dehydration is actually doing to your blood volume and cognitive output, and how Qore is building cooling and hydration systems trusted by special operations forces and elite endurance athletes. We also get into why managing heat is the most overlooked variable in the wearable and performance optimization space.
A direct, gear-tested conversation about the physiology most people ignore until it shuts them down.Teaching Cells to Cure w/Dr. Armon S.The Silicon Fox Podcast with Mitchell Leshchiner2026-08-31 | Armon Sharei was born in the Bay Area, grew up in Iran and Dubai, did chemical engineering at Stanford and a PhD in chemical engineering at MIT, where his lab accidentally discovered that squishing a cell at high speed briefly disrupts its membrane and lets you put almost anything inside it. A postdoc in immunology at Harvard followed, then ten years building his first company on that discovery, raising roughly 300 million in equity plus another 100 million through a Roche partnership, going public on the NYSE in 2020, and reaching 150 people and three clinical trials at peak. When biotech financing crashed, he and the board disagreed on whether to bet everything on a single clinical readout. They agreed to disagree, and Portal was born as the platform version of the idea.
His argument is that small molecules and biologics have reached the end of their reign. Their greatest wins, antibiotics and vaccines, changed the reasons people die, but the diseases that remain are complex enough that no single molecule is going to be the answer, which is why a billion dollars of development can buy a cancer patient two extra months. Cells are complex machines capable of sophisticated behavior, and the bottleneck has never been ambition but delivery. Portal's tech is a thin piece of silicon with holes slightly smaller than the cells passing through it. A seven micron T cell going through a five micron hole gets squeezed, opens up, takes on whatever is around it, and reseals in about thirty seconds. No virus, no clean room, no seven people in bunny suits, and eventually no shipping cells across the country at over 100K per patient in pure cost.
Plus: why he thinks AI target discovery keeps rediscovering targets the field already knew about, and why the data that would actually de-risk phase one does not exist, because sponsors have every incentive not to measure what they do not want to find. Why a cell scale simulator is plausible and a human scale digital twin is not in his lifetime. Why a cell therapy shot on goal costs 10x a small molecule one, and what happens to iteration when that gap closes. His case against me too drugs and for real price negotiation. And the difference between hardwiring a cell into a permanent killing machine and giving it a temporary program that runs, finishes, and lets the cell go back to normal. Portal is now 30 people, has raised 24 million, has over 100 customers including 10 of the major pharma companies, and took 8 million from DARPA to build a machine that could sit next to the patient.
A grounded conversation about delivery, cost of iteration, and why cell therapy is still stuck in the mainframe era.Everyone has an optimal Path w/ Anson W.The Silicon Fox Podcast with Mitchell Leshchiner2026-08-30 | 1. Use code "siliconfox20" for 20% off your first SiPhox Health test → siphoxhealth.com/programs
Anson Whitmer, PhD, spent a decade in academia studying the cognitive, neural, and genetic causes of rumination, publishing in top journals and doing his postdoc at Stanford under Ian Gotlib. He left because understanding causes was not producing solutions fast enough. He joined Calm as a founding team member and helped scale it from a one bedroom apartment to a two billion dollar valuation, moving meditation from something an early investor dismissed as fit only for college campuses and Burning Man into a mainstream habit for millions. Now, with Calm's founding engineer and Tony Robbins as co-founders, he is building The Path, and he believes AI is a once in history opportunity to actually bend the curve on mental illness rather than nibble at it.
The core insight is about variance. Two people with the same problem might take five sessions to get better, or forty, or eighty. Great therapists find the shortest route intuitively, but that skill has never been systematized, which is part of why psychotherapy outcomes have stayed roughly flat across decades of research. Anson's bet is that AI is unusually good at reading the messiness and noise in that data, and that the optimal path for a given person and a given problem is something a system can learn and keep improving on. Early outcomes data at The Path is better than he expected, and his point is that this is the worst the technology will ever be.
Plus: the sensing layer that makes prevention realistic, including facial expression analysis, tonal markers of low mood, and eventually sleep shifts, so the system can reach out before someone spirals instead of waiting for them to book an appointment. Why accessibility is the real unlock, from doing a session on your couch in pajamas to the AI Tony Robbins persona that gets people through the door who would never open a therapy app. Why he blocks under 18 users today but wants tools like this available to his own sons eventually, since most serious mental health problems start young and get treated far too late. And the scale problem this could finally answer: 18 million American veterans served by 7,000 VA psychotherapists, three month waiting lists, and entire regions with no mental health professionals at all. An optimistic conversation about what happens when help stops being scarce.The Case for Open Science in Antibiotics W/ Akhila K.The Silicon Fox Podcast with Mitchell Leshchiner2026-08-18 | 1. Use code "siliconfox20" for 20% off your first SiPhox Health test → siphoxhealth.com/programs
In this episode of The Silicon Fox Podcast, we sit down with Akhila Kosaraju, a physician turned computational biologist who now runs Phare Bio, a nonprofit using AI to design brand new antibiotics from scratch. We get into the origin story: how a 2020 discovery out of Jim Collins' lab at MIT, using a simple graph neural network trained on 2,500 compounds, found a molecule that could kill superbugs no existing drug could touch, and how that discovery sparked a global movement almost overnight.
We dig into why Phare Bio chose a nonprofit and hybrid financing model over venture capital, the brutal math behind it (a successful antibiotic takes 33 years just to break even), and how AI lets them design molecules atom by atom instead of screening for them after the fact. Akhila breaks down the three parts of their discovery engine, why only 3,000 researchers worldwide are working on this problem, and why Phare Bio gives away its training data for free without giving up its IP. Plus: why we're racing against two clocks (bacteria develop resistance in under 6 years, but new drugs take over 13 to reach patients), the legislation that could finally fix the industry's broken incentives, and why Akhila thinks AI drug discovery, on the hundredth anniversary of Fleming's discovery of penicillin, could finally put patients back at the center of the process.
A candid conversation about outracing resistance, rethinking incentives, and rebuilding a broken pipeline with AI.
Jeff Tang had lymphoma at fourteen, moved to San Francisco at nineteen as a software engineer, and went through Y Combinator in 2021 with a company that had nothing to do with health. When that stopped feeling right, he asked what he actually cared about and landed on health. He started a meal prep company called EatBlueprint, cooking meals inspired by Brian Johnson's protocol. Six months in, Johnson reached out, they ran an event together, and he acquired the business. Jeff spent about a year at Blueprint launching meals nationwide and building Blueprint Biomarkers, the diagnostics arm covering MRIs, a 300 biomarker blood panel, the first commercial microplastics test, and epigenetic age testing.
He left a year ago and went in the opposite direction, away from apps and toward rooms full of people. Testosterone testing parties came first, prompted by the numbers on male fertility decline. Then a sister brand to sperm racing called Spermworms, a pineapple flavored fertility gummy that grew out of a viral event that pulled close to a billion impressions. Now it is peptide parties, with San Francisco done twice, Los Angeles next, and New York in October. His argument is that health is physical and social in a way software cannot touch. He points to Hyrox versus Spartan and Tough Mudder to explain why: a once a year event feels disconnected from the training you do at home, while a gym is where the two or three or five times a week ritual actually lives. Coffee and Chill shows up every two weeks in a different Venice backyard or parking lot and has expanded to six cities on that alone.
Plus: what he learned at the FDA peptide meeting, where six of seven peptides got a positive recommendation for the bulks list without a final decision yet. Why he sees peptides sitting between drugs and supplements rather than in one bucket, given that insulin and the GLP-1s are peptides and over a hundred are already approved. Why he thinks the consumerization of healthcare is a symptom rather than a trend, driven by six month waits and fifteen minute appointments and prior auth. A frank disagreement with Mitchell about what public reaction to the United Healthcare shooting says about the system. The tension he still has not solved between events that are fun and events that are educational, since the drier one taught him more and traveled less. And a full explanation of the penis botox party, which is exactly what it sounds like.
A conversation about rituals, bodies, and why the health products that stick are the ones you show up to in person.Were Dosing Blind w/ Dr. Jaspal Ricky SinghThe Silicon Fox Podcast with Mitchell Leshchiner2026-07-31 | Use code "siliconfox20" for 20% off your first SiPhox Health test → siphoxhealth.com/programs
In this episode of The Silicon Fox Podcast, we sit down with a triple-boarded physician running a regenerative medicine program inside an academic center — not a cash-pay clinic. We get into the field's dirty secret: everyone argues whether PRP and stem cells work, but almost nobody knows what dose they're injecting. Platelet concentration varies by more than 10x between commercial kits, which means a decade of studies may be comparing apples to oranges.
We dig into why orthobiologics is a process, not a product, what patients asking for "stem cells" off TikTok actually need, and where the industry's marketing crosses from optimistic into dishonest. Then the gray area between PT and surgery — why patients get sent to the OR without ever hearing about the middle option, and how catheters and stents made open heart surgery the exception. Plus: why "too old" is the wrong filter for stem cell therapy, the patient who funded nearly 100 procedures for people who couldn't afford them, and what has to happen for insurance to ever cover this.
A candid conversation about dosing, hype, and fixing regenerative medicine from the inside.A Pediatrician in Every Home w/ Rich BernerThe Silicon Fox Podcast with Mitchell Leshchiner2026-07-20 | 1. Use code "SFOXWL" for 10% off your first BioPro+ order from BioProtein Technology → bioproteintech.com/SFOXWL
In this episode of The Silicon Fox Podcast, we sit down with Rich Berner, a two-time healthcare exit CEO and former private equity operator who is now taking on what he calls the ultimate challenge in healthcare access: pediatrics.
We break down why nearly 60% of rural counties lack a general pediatrician, how 1 in 3 American children lack access to essential care, and why pediatrics stayed underbuilt in digital health while adult primary care got flooded with capital. Rich explains why video-only telehealth was a feature and not a company, why Blueberry made a physical at-home diagnostic kit non-negotiable, and how the model keeps 99% of patients out of the ER.
We also dive into the business of fixing it: why Blueberry runs toward Medicaid when most companies run away, how "guaranteed savings" pitches actually land with health plans, what makes a digital health company acquirable versus just venture-backed, and where the next wave of consolidation hits as the industry works off its 2021 hangover.Building Through the Pain w/ Bradley BaumThe Silicon Fox Podcast with Mitchell Leshchiner2026-07-08 | 1. Use code "SFOXWL" for 10% off your first BioPro+ order from BioProtein Technology → bioproteintech.com/SFOXWL
In this episode of The Silicon Fox Podcast, we sit down with Brad Baum, former VC turned founder, co-creator of the Founder Mental Health Pledge, and CEO of Stance Health, to explore what happens when the person behind "hustle responsibly" decides mental health isn't the whole story, chronic pain is next.
We get into Brad's arc from VC to founder, how the Founder Mental Health Pledge became a movement, and the gap between founders crying on the bathroom floor and the "we're crushing it" routine onstage. We dig into whether hustle responsibly is a real cultural shift or a market-cycle vibe, where VCs still get it wrong, and how founders should talk to their boards about mental health without it becoming a governance event.
Then the pivot: why Brad and co-founder Adam, who scaled SmileDirectClub, moved from founder mental health to chronic pain, one of medicine's best-documented comorbidities and still one of its most underbuilt categories, what's left after Hinge, Sword, and Omada, and where the next durable healthtech category gets built.
A candid conversation on founder burnout, chronic pain, and building a health company while staying honest about your own.The Biology of National Defense w/ Dr. Michael KoerisThe Silicon Fox Podcast with Mitchell Leshchiner2026-06-29 | 1. Use code "SFOXWL" for 10% off your first BioPro+ order from BioProtein Technology → bioproteintech.com/SFOXWL
In this episode of The Silicon Fox Podcast, we sit down with Michael Koeris, Sample6 founder, Keck professor, Addgene board member, and now Director of DARPA's Biological Technologies Office, to explore what changes when a founder who has started, scaled, and exited bio companies takes the seat that hands out national-security money instead of venture money.
We get into the real difference between DARPA dollars and VC dollars — oversight, IP, dual-use obligations, exit path, and what gets funded when the mandate is national security rather than return. Koeris walks through the Heilmeier questions that kill most pitches, the projects a VC would never touch but BTO will, and the inverse. We dig into dual-use biology head-on: every pathogen-detection tool is also a weapons-enablement tool, and how you build a program responsibly on that razor's edge.
Then the flagship bets under his tenure, agricultural security as national security, $4.5M spread across 45 AI-in-biology catalyst shots, and his personal moonshot of biology in space, plus what RADx taught him about national bio-mobilization, and a fixed-tenure clock that forces a choice between legacy bets early and de-risked wins late.
A candid conversation on the founder-to-funder seat, the limits and uses of the DARPA model in messy, slow, regulated biology, and what it takes to fund the bleeding edge responsibly.The OS For Human Health w/ Josh C.The Silicon Fox Podcast with Mitchell Leshchiner2026-06-19 | Use code "SFOXWL" for 10% off your first BioPro+ order from BioProtein Technology → bioproteintech.com/SFOXWL
In this episode of The Silicon Fox Podcast, we sit down with Josh Clemente, co-founder of Levels and former SpaceX engineer, to explore what the engineering mind sees in human metabolism and where that frame stops working. We discuss feedback loops, sensors, and set points as a vocabulary for the body, why a chemistry set routed by hormones resists clean systems thinking, and what six years deep in metabolic health has either humbled or sharpened about his engineer's instincts.
We dive into the honest reckoning on continuous glucose monitoring: the peer-reviewed pushback from Stanford and JAMA, what Josh still believes versus what he now holds with far less certainty, and, if glucose was never the master signal, what actually is.
We get into the sensor stack and what comes after glucose, why a second continuous biomarker has taken so long, the real bottleneck on continuous hormone sensing, and where defensibility lives now that CGM hardware has gone commodity with Stelo and Lingo. We also explore the MAHA moment: what it's like to be early and right on chronic disease, where the movement gets the diagnosis right and the prescription wrong, and which claims are load-bearing versus politically convenient.
A candid conversation on the limits of the engineering mindset in biology, the future of the sensor stack, and what it actually takes to move metabolic health.The Screening Revolution: AI Diagnostics, Whole-Body MRIs, and Proactive Health with Dr. ChungThe Silicon Fox Podcast with Mitchell Leshchiner2026-06-14 | Use code "siliconfox20" for 20% off your first SiPhox Health test → siphoxhealth.com/programs
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In this episode of The Silicon Fox Podcast, we sit down with Dr. Danna Chung of Ezra and Function Health to explore the future of preventive medicine and AI-powered early detection. We discuss the promise and controversy of whole-body MRI screening, the challenge of balancing early detection with overdiagnosis, and whether healthcare is finally shifting from treating disease to preserving health.
We dive into what AI is actually changing in medical imaging, what FDA clearance taught Ezra about the limits of clinical AI, and whether radiologists should view AI as a collaborator or competitor. We also explore the economics of prevention: why a 15-minute, $500 MRI could be an unlock, why insurers struggle to pay for prevention, and who ultimately benefits from catching disease early.
Finally, we examine the Function Health and Ezra vision of combining imaging, biomarkers, and AI into a longitudinal view of health—and ask where the line lies between rigorous longevity science and wellness hype.
A thoughtful conversation on prevention, AI in healthcare, and the future of early detection.The Bottleneck In Biotech with Dr. Mark Van ZeeThe Silicon Fox Podcast with Mitchell Leshchiner2026-06-08 | Use code SILICON for 10% off your first month at AMP Fitness → amp.ai
In this episode of The Silicon Fox Podcast, we sit down with the founder of Saku Biosciences, who spun a UCLA PhD project into a deep-tech company rather than another paper. The thesis: biotech isn't limited by R&D, it's limited by stability and scale, and the real bottleneck is that a strain which crushes it in a well plate falls apart in a 10,000L bioreactor. We get into PicoShells, the platform built to compress years of strain engineering into weeks, why FACS is the unlock nobody could pull off before, and the single biggest hidden tax on the bioeconomy.
We dig into building a company out of academia, splitting founder roles with Dino, what the PhD didn't teach him, and why part of Saku moved to North Carolina's RTP instead of staying in LA. Then the wedge problem: how you pick a market when your platform is horizontal across GLP-1s, insulin, alt-food, and biofuels, which market pays most for a 2x yield bump versus which one needs it most, and whether the cultivated-food thesis is still investable after the 2023–24 collapse. We push on the capital reality, what generalist VCs get wrong about biomanufacturing, whether non-dilutive money is a moat or a distraction, and the milestone that turns Saku from "interesting platform" into "obvious investment."
Then the big frame: synbio promised a $4T economy and didn't land it, is biology eating the world, or is the world too slow to let it? What's overhyped, what's underhyped, where AI actually fits, and what the U.S. has to fix to compete with China.
A grounded conversation about why biomanufacturing is hard, what it takes to scale biology, and the unlock he's still waiting for.You Shouldnt Optimize Alone with/ Justin HibbertThe Silicon Fox Podcast with Mitchell Leshchiner2026-05-31 | Use code "siliconfox20" for 20% off your first SiPhox Health test → siphoxhealth.com/programs
In this episode of The Silicon Fox Podcast, we sit down with Justin, founder of Everhaus, who spent his 20s as the lead host at Hakkasan selling people the best night of their life, and then walked away to build a longevity club. We get into the personal 180: what people were actually buying in nightlife, the moment that whole world stopped working for him, and whether nightlife and longevity are really opposites or two expressions of the same underlying skill. We dig into the "indulgence operating system", what a decade reading rooms taught him about human behavior that the wellness world doesn't grasp, why people chase the indulgent version even when they know better, and whether the shift toward performance and longevity is a real cultural movement or a rich-person trend with good PR. We get into his case that discipline is a skill rather than a personality trait, the habits he got completely wrong at first, the most overrated rituals in wellness, and where the industry straight-up lies to people. And we push on the thesis underneath Everhaus: that you can't out-discipline your environment, that removing friction beats willpower, and whether a private club is a genuine cultural shift or just nightlife's social pull wearing a healthy coat of paint.
Then the bet itself: why build this in Las Vegas rather than Miami or Austin where the market's already proven, whether cultural change comes from the resorts or the residents, and what a Vegas native wants his city to become for the kids growing up there now.
A candid conversation about indulgence, discipline, and whether you can re-engineer a city built to break your willpower.Killing Cancer At The Source w/ Dr. Jeff LiuThe Silicon Fox Podcast with Mitchell Leshchiner2026-05-29 | Use code "siliconfox20" for 20% off your first SiPhox Health test → siphoxhealth.com/programs
In this episode of The Silicon Fox Podcast, we sit down with Jeff of FinalDose to ask whether sixty years of drug discovery has been working at the wrong layer entirely, chasing proteins when disease actually begins in the DNA.
We get into the undruggable 85%: the vast majority of disease drivers that have no targetable protein, and why that left most of medicine off-limits. We dig into whether protein-first was ever a scientific conviction or just an artifact of the tools and incentives that happened to exist. We unpack the "terminus layer", what a clean way to kill a diseased cell actually looks like versus the messy mechanisms therapies rely on today, and the harder problem of a molecule that reads DNA inside a living cell and decides, on the spot, whether that cell is diseased. If one platform really does unlock most of the currently undruggable targets, what happens to the $2.6B-per-drug, ten-year model, and does the category of "cancer" eventually dissolve into something else entirely?
A rigorous, first-principles conversation about whether we've been treating disease one layer too late.Breathing: The New Biomarker. The hidden link between environment, inflammation, and longevity.The Silicon Fox Podcast with Mitchell Leshchiner2026-05-03 | Use code "siliconfox20" for 20% off your first SiPhox Health test → siphoxhealth.com/programs
Fuel performance with Momentous. Use code "Siliconfox" for up to 35% off → livemomentous.com
In this episode of The Silicon Fox Podcast, we sit down with the team at Climatic to ask why lungs, the only internal organ directly exposed to the outside world, have been left out of the wellness conversation entirely.
We discuss what's actually happening inside the airways with every breath, why mucociliary clearance is the most important defense system nobody's heard of. We get into why VO2 max keeps showing up as one of the strongest predictors of lifespan, how compromised oxygenation drives cascades through the cardiovascular and immune systems, and why "go see a pulmonologist" remains the only lung health intervention most people can name. We also dig into what a proactive lung health routine could actually look like, and whether respiratory wellness is positioned to become the next gut health, a daily consumer category rather than a reactive medical one. A rigorous, evidence-first conversation about the organ system the wellness industry forgot.The Drivers of Aging: Cellular damage, chronic inflammation, and why modern life is accelerating itThe Silicon Fox Podcast with Mitchell Leshchiner2026-04-24 | Sponsors: Use code "siliconfox20" for 20% off your first SiPhox Health test → siphoxhealth.com/programs
Fuel performance with Momentous. Use code "Siliconfox" for up to 35% off → livemomentous.com
In this episode of The Silicon Fox Podcast, we sit down with Matthew Craine of Semaine Health to ask why aging, the single biggest driver of chronic disease, is still treated as an inevitability instead of a measurable, modifiable process.
We discuss what's actually happening inside a cell as it ages, why chromatin deterioration and DNA damage may be more cause than symptom, and how chronic inflammation turns cellular wear into systemic disease. We get into why two people born the same year can be biologically decades apart, and which lifestyle interventions actually hold up at the cellular level versus which ones are wishful thinking.
A rigorous, evidence-first conversation about the organ system medicine has been content to let decay.Heat injury prevention #podcast #heat #thermoregulation #hydration #electrolytesThe Silicon Fox Podcast with Mitchell Leshchiner2026-04-10 | ...The Toilet As a Health Device: The next wave of health is continuous and preventativeThe Silicon Fox Podcast with Mitchell Leshchiner2026-03-29 | Sponsors: Use code "siliconfox20" for 20% off your first SiPhox Health test → siphoxhealth.com/programs
Fuel performance with Momentous. Use code "Siliconfox" for up to 35% off → livemomentous.com
In this episode of The Silicon Fox Podcast, we sit down with Scott Hickle to ask why gut health, the system linked to everything from immunity to cancer to mental health, is still almost completely unmonitored.
We discuss why 70 million Americans have digestive diseases and nobody treats it like a crisis, what ultra-processed food is actually doing to the microbiome and why colon cancer is now the leading cause of cancer death in men under 50.
We also get into why gut health is the biggest gap in the wearable and continuous monitoring revolution.
A direct, evidence-first conversation about the organ system medicine forgot to measure.AI Biology Revolution: AI drug discovery, de novo proteins, and the future of therapeuticsThe Silicon Fox Podcast with Mitchell Leshchiner2026-03-13 | Sponsors: Go to amp.ai/go for the most convenient, sleek, and high-quality at home gym experience
Fuel performance with Momentous. Use code "Siliconfox" for up to 35% off → livemomentous.com
In this episode of The Silicon Fox Podcast, we sit down with Dr. Ori Zelichov, physician, synthetic biologist, co-founder of a CRISPR cancer therapy company as a med student, and now Co-Founder, President, and CMO of ZipBio.
Drug development still takes 10–15 years and $2B+ per molecule. Ori breaks down what's broken in that pipeline, what most AI drug discovery companies get wrong, and why compressing proteins rather than designing them from scratch changes the math.
We go deep on spatial biology, what AI sees in cancer tissue that human pathologists can't, and trace the full arc from Ori's original CRISPR insight as a student to watching that work reach real patients in pivotal trials a decade later.
A conversation about what happens when software logic meets drug design and what the pipeline looks like if this technology actually matures.Next Generation Medicine: Personalized care, AI, and the end of algorithmic medicine w/ Dr. AnantThe Silicon Fox Podcast with Mitchell Leshchiner2026-03-08 | Sponsors: Use code "siliconfox20" for 20% off your first SiPhox Health test → siphoxhealth.com/programs Fuel performance with Momentous. Use code "Siliconfox" for up to 35% off → livemomentous.com
In this episode of The Silicon Fox Podcast, we sit down with Dr. Anant Vinjamoori, Stanford-trained biologist, Harvard MD/MBA, former product lead at Virta Health ($3B), and Chief Longevity Officer at Superpower, to ask why modern medicine still isn't designed to keep people well.
We discuss what longevity medicine actually is beyond the hype, why primary care is structurally broken, what the next generation of biomarkers makes possible, and what it takes to build real clinical products in a system resistant to change.
A sharp, no-hype conversation about rebuilding medicine from the cell up.Stephen Klasko: Why more spending keeps making health worseThe Silicon Fox Podcast with Mitchell Leshchiner2026-02-27 | Sponsors: Go to amp.ai/go for the most convenient, sleek, and high-quality at home gym experience
Fuel performance with Momentous. Use code "Siliconfox" for up to 35% off → livemomentous.com
In this episode of The Silicon Fox Podcast, we sit down with Dr. Stephen Klasko, former DJ, OB/GYN, Wharton MBA, the leader who grew Jefferson Health from $1.8B to $9B, current General Catalyst venture partner, and now getting a law degree in AI in his 70s.
Why is American healthcare still fundamentally a "sick care system"? We spend 2x what other countries spend and get worse outcomes. Everyone knows the numbers. Nothing changes. Stephen names the broken incentives, the players protecting the status quo, and why zip code still determines who lives and who dies.
We go deep on what's wrong with medical education, why we select for the wrong traits, and what changes when you start designing the system around empathy instead of test scores. With AI here now, the entire model needs to be rethought.
We unpack General Catalyst's big bet, acquiring a health system to prove out "health assurance" over health insurance, what that actually means for a regular person, and whether this model can scale.
We also explore where AI is already reshaping healthcare, what the industry sees coming and is choosing to ignore, and why Stephen was concerned enough about unintended consequences to go back to school at 70.
A grounded conversation about what's actually broken in healthcare, who's blocking the fix, and what it takes to rebuild the system from the inside out.High Performance Operator: What sports teaches about execution, trust, and building teamsThe Silicon Fox Podcast with Mitchell Leshchiner2026-02-23 | Sponsors: Use code “siliconfox20” for 20% off your first SiPhox Health test → siphoxhealth.com/programs
Fuel performance with Momentous. Use code “Siliconfox” for up to 35% off → livemomentous.com
In this episode of The Silicon Fox Podcast, we sit down with Mitchell Heath, founder of Teamworks, to unpack the “unfair insight” behind building infrastructure for elite sports organizations.
What was actually broken inside top programs day-to-day? Why didn’t traditional enterprise tools work in sports? And what was the early proof that this wasn’t just a feature, it was inevitable?
We go deep on trust. In sports, you don’t sell, you get invited in. Mitchell breaks down the first wedge, how one team turned into ten, the status dynamics inside organizations, and the one sales move that works in sports but would fail in normal SaaS.
We also explore the platform evolution, from thin edge product to embedded infrastructure, and how to build venture-scale outcomes in a small, elite market. From culture and hiring to maintaining speed in environments that can’t tolerate failure, this is a masterclass in operating at a high standard.
A grounded conversation about trust, execution, and what elite organizations can teach the rest of the business world.Are We Getting Healthier? VCs input on the speed of healthcare progressThe Silicon Fox Podcast with Mitchell Leshchiner2026-02-20 | Sponsors: Use code “siliconfox20” for 20% off your first SiPhox Health test → siphoxhealth.com/programs
Fuel performance with Momentous. Use code “Siliconfox” for up to 35% off → livemomentous.com
In this episode of The Silicon Fox Podcast, we sit down with Daniella from 2048 Ventures to unpack a core tension in healthcare: if biotech, AI, sensors, and data are advancing rapidly, why isn’t population health improving?
Is healthcare a broken science problem, or a broken market problem? We discuss why access-driven companies scale faster than breakthrough science, what founders misunderstand about selling into payers and health systems, and how specialized health VCs think differently from generalist tech funds.
We also explore the consumerization of health, what people actually want (convenience, longevity, peace of mind), which categories may define the next decade, and what types of founders are best positioned to build enduring companies in a regulated, incentive-misaligned system.
A sharp, grounded conversation about incentives, venture math, and what it really takes to build in health, not hype, just reality.Clinicians Are Here to Stay: Why health data alone wont give you results w/ Josh WhalenThe Silicon Fox Podcast with Mitchell Leshchiner2026-01-30 | In this episode of The Silicon Fox Podcast, we sit down with Josh Whalen to unpack why blood labs are becoming the canary in the coal mine for consumer health, and what their rise reveals about where the entire category is headed.
We explore why blood testing is one of the first healthcare domains to truly go consumer-first, why it lagged wearables for so long, and whether the real value lies in the test itself or in longitudinal data, interpretation, and ownership. From there, the conversation widens into a sharper truth: consumer health isn’t a medical problem, it’s a trust, motivation, and distribution problem.
A grounded conversation about ownership, trust, and the real infrastructure behind consumer health, not hype, not miracles, just reality.
Sponsors: Use code “siliconfox20” for 20% off your first SiPhox Health test → siphoxhealth.com/programs
Fuel performance with Momentous. Use code “Siliconfox” for up to 35% off → livemomentous.comThe Future of Healthcare Access w/Alysaa CoThe Silicon Fox Podcast with Mitchell Leshchiner2026-01-23 | In this episode of The Silicon Fox Podcast, we sit down with Alyssa Co, investor at BCV, to examine why healthcare remains structurally broken, and what it will actually take to improve access in the healthcare system.
From Alyssa’s perspective investing in healthcare infrastructure, we move beyond surface-level innovation to the invisible layer that determines outcomes: prior authorization, compliance, data flow, interoperability, and trust. We discuss why these “boring” backend systems often deliver more leverage than new treatments, how underwriting health infrastructure differs from biotech or consumer health, and where AI meaningfully helps versus where it’s oversold.
We also explore why now is different for health data and AI, what critical APIs and data flows are still missing, and whether AI-driven infrastructure lowers real barriers or simply reshapes old constraints. Finally, we dig into returns, not just financial, but societal, including equity, access, and the risks of over-centralized health systems.
A grounded, systems-level conversation about the future of healthcare, where access is won or lost in implementation, not ideas.
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Fuel performance with Momentous. Use code “Siliconfox” for up to 35% off → livemomentous.comInside DARPA: The biotech research happening in the Department of War With Dr. Chris BettingerThe Silicon Fox Podcast with Mitchell Leshchiner2026-01-15 | In this episode of The Silicon Fox Podcast, we sit down with Dr. Christopher Bettinger to explore how DARPA actually operates, and why some of the hardest problems in biotech can only be tackled outside traditional markets.
Chris brings a rare inside view as a DARPA Program Manager, former DARPA Young Faculty Award recipient, and leading biomedical engineer. We start by breaking down what DARPA is, how it differs from venture capital and academic funding, and how its national security mandate fundamentally changes how projects are selected, managed, and evaluated.
We dig into the mechanics of the DARPA model: fixed-term leadership, phase-based programs, intense technical oversight, and what “success” means when the goal isn’t a company or a paper, but a step-change in capability. Chris explains why DARPA funds work VCs won’t touch, how dual-use biotech fits into this strategy, and what happens when a project works beyond a PM’s tenure.
We then dive into Smart-RBC (Smart Red Blood Cells), one of DARPA’s most ambitious biology programs. Chris unpacks why it’s DARPA-hard, the biological “miracles” required, how it differs from approaches like EPO, and why now is the right moment under the Heilmeier framework.
A candid conversation about risk, incentives, talent, and building biology where markets can’t lead.
Sponsors: USE CODE “siliconfox20” for 20% off your first SiPhox Health test → siphoxhealth.com/programsThe Race To 160: Longevity as a Root-Cause Market and Preventative Biotech w/ Omri Amirav-DroryThe Silicon Fox Podcast with Mitchell Leshchiner2026-01-08 | In this episode of The Silicon Fox Podcast, we sit down with Omri Amirav-Drory to explore what it really takes to build and invest in biology as a programmable system.
Omri’s career spans nearly every layer of TechBio: a biochemistry PhD, a Stanford postdoc, founding Genome Compiler to bring software primitives into synthetic biology, helping scale Twist Bioscience after acquisition, and now backing early scientist-founders as a partner at NFX Bio. We unpack how those experiences shaped his conviction that biology can be engineered but only if we respect where it fundamentally resists software thinking.
We dig into the hard lessons from synthetic biology’s first wave: why reproducibility and manufacturing matter more than clever models, where AI meaningfully accelerates biology and where it doesn’t, and which pitch narratives immediately fall apart under real-world constraints. Omri shares how he evaluates risk differently as a former builder from lab reliability to regulatory path to time-to-truth.
The conversation widens to the current TechBio moment. We discuss which parts of the stack are finally maturing, which are still missing, and why unglamorous infrastructure design tools, biological abstraction layers, scale-up, and operational discipline may matter more than the next flashy modality. We also explore whether biology-first, preventive care is actually plausible in the next decade, or still ahead of its time.
A candid, operator-level conversation about building durable biotech companies grounded in biology, shaped by engineering, and informed by scars.
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Fuel performance with Momentous, the cleanest supplements backed by elite science and trusted by top performers. Use code “Siliconfox” for up to 35% off → livemomentous.comDoctors cant make you healthy. Be the CEO of your own health #health #podcast #ceo #wellnessThe Silicon Fox Podcast with Mitchell Leshchiner2026-01-04 | ...AI Before the Doctor. AI Health Copilots and the Future of Medical Intelligence w/ Rob SargsyanThe Silicon Fox Podcast with Mitchell Leshchiner2026-01-04 | In this episode of The Silicon Fox Podcast, we sit down with Robert Sargsyan, founder of Docus AI, to explore a fundamental shift in healthcare: the move from institution-centered medicine to individual-centered intelligence.
We discuss why healthcare has resisted transparency, what it really means to democratize medical intelligence, and whether the future of care starts with doctors or with data.
Robert breaks down AI as a medical partner, not a replacement: what “doctor-in-the-loop” actually looks like, where AI already outperforms legacy systems, where it still fails, and how trust should be defined in an era of probabilistic intelligence.
The conversation expands globally, examining how healthcare inequality changes when diagnosis becomes software, the idea of a “global medical brain,” and the regulatory and cultural challenges of deploying health AI across borders.
We also dive into the future of personalized medicine AI trained on individuals, health digital twins, data ownership, interoperability, and whether public health still matters in a world of perfect personalization.
A grounded, philosophical, and technical conversation about the future of healthcare from systems to souls.
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Fuel performance with Momentous, the cleanest supplements backed by elite science and trusted by top performers. Use code “Siliconfox” for up to 35% off → livemomentous.comIs Biology Becoming Software? The Convergence of Code, Cells, and Capital with Joe H.The Silicon Fox Podcast with Mitchell Leshchiner2025-12-22 | In this episode of The Silicon Fox Podcast, we sit down with Joe Horsman to cut through the noise in modern biotech and health investing and ask a simple question: what actually works, and what’s just well-marketed science?
We dig into the reality behind AI-driven biology, multi-omics, and computational discovery. Joe breaks down where cheaper sequencing truly changed the field, where AI has delivered real biological insight, and where claims fall apart under scrutiny. We explore how to separate breakthroughs from boom-bust cycles, why biology is not software (yet), and what parts of the stack, from discovery to manufacturing, remain the true bottlenecks.
We also unpack how to evaluate health and biotech startups beyond buzzwords. We discuss data quality, reproducibility, validation, regulation, and scale, why novelty is often overvalued, and how durable moats are actually built. The conversation spans platform versus vertical bets, data ownership, lab costs trending toward zero, and what today’s founders consistently underestimate.
Finally, we look ahead at the next decade of health: the shift from sick care to biology-first care, what feels inevitable versus speculative, where AI and omics will create real leverage, and which underhyped areas may define the next generation of biotech companies.
A grounded, technical conversation about the future of health, without the hype.
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Fuel performance with Momentous, the cleanest supplements backed by elite science and trusted by top performers. Use code “Siliconfox” for up to 35% off → livemomentous.comRethinking Early Detection: Proactive whole-body MRI, cancer, and why information is power.The Silicon Fox Podcast with Mitchell Leshchiner2025-12-12 | In this episode of The Silicon Fox Podcast, we sit down with Dr. Dan Durand, physician, President, and Chief Medical Officer of Prenuvo, the world’s largest network of clinics dedicated exclusively to whole-body MRI and proactive diagnostics.
We explore why modern medicine is built to react to disease instead of preserving health, how whole-body MRI is shifting care from emergency rooms to calm outpatient settings, and what actually happens when you scan people who feel perfectly healthy. Dr. Durand breaks down what MRI can reveal long before symptoms appear, how often early-stage cancer and silent pathology are found, and why “incidental findings” may be a feature, not a flaw, of proactive care.
We also dive into the future of prevention: multi-omic baselining, AI copilots for radiologists, body composition analytics, and a world where individuals own deep, longitudinal data about their bodies. Finally, we tackle the hardest questions head-on, including the psychology of knowing, overdiagnosis concerns, and why having more information can give people agency not just over how they live, but how they prepare for what comes next.
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Get $300 off your first Prenuvo MRI Scan! $300 off → Prenuvo.com/SILICONFOXYou Dont Need Surgery: Rethinking Surgery Necessity and the Emergence of Value Based CareThe Silicon Fox Podcast with Mitchell Leshchiner2025-12-04 | In this episode of The Silicon Fox Podcast, we sit down with Dr. Ryan Grant, neurosurgeon and founder of Vori Health, who is leading a radical shift in how we think about surgery, pain, and musculoskeletal care.
We unpack why nearly half of spine and orthopedic surgeries are unnecessary, how traditional fee-for-service incentives push patients toward the operating room, and the immense human and financial cost of treating symptoms instead of solving root causes. Dr. Grant breaks down why back pain is so misunderstood, what actually drives long-term recovery, and how virtual-first, value-based care is changing the game.
We also dive into the future of musculoskeletal health: personalized care pathways that combine physical therapy, metabolic support, lifestyle changes, and real-time data to prevent surgery before it’s even considered and why this shift could save billions while restoring health and mobility for millions.
Sponsors: USE CODE “siliconfox20” for 20% off your first SiPhox Health test → siphoxhealth.com/programs
Fuel performance with Momentous, the cleanest supplements backed by elite science and trusted by top performers. Use code “Siliconfox” for up to 35% off → livemomentous.comHormone Tracking: How Continuous monitoring is evolving w/ Marina Pavlovic RivasThe Silicon Fox Podcast with Mitchell Leshchiner2025-11-29 | In this episode of The Silicon Fox Podcast, we sit down with Marina Pavlovic Rivas, co-founder and CEO of Eli Health.
We unpack why hormone health, a critical yet nearly invisible foundation of wellness, has been systematically ignored by modern medicine, how hormonal dysregulation silently undermines everything from stress resilience to metabolic health, sleep, mood, and performance, and why traditional lab snapshots fail to catch the real story.
We also dive into the future of truly personalized, preventative health: the hormone-centric biomarkers we should monitor long before symptoms arise, how real-time hormonal data gives you control over stress, recovery, fertility, and performance, and why widespread adoption of tools like Hormometer could shift the paradigm from reactionary care to proactive, data-driven wellness.
Sponsors: USE CODE “siliconfox20” for 20% off your first SiPhox Health test → siphoxhealth.com/programsMedicine is Broken: The real cause of chronic disease w/ Dr. Robert LufkinThe Silicon Fox Podcast with Mitchell Leshchiner2025-11-21 | In this episode of The Silicon Fox Podcast, we sit down with Dr. Robert Lufkin, a physician, researcher, and systems-thinking pioneer who has become one of the loudest voices calling out the failures of modern medicine.
We break down why our healthcare system is built to treat symptoms instead of root causes, how chronic disease became the defining epidemic of our time, and why metabolic dysfunction sits at the center of everything from diabetes to Alzheimer’s. Dr. Lufkin explains why insulin resistance remains massively overlooked in clinical practice, what medical training gets dangerously wrong, and how imaging can detect disease years before standard labs ever change.
We also dive into the future of prevention and performance: the biomarkers we should be tracking a decade before symptoms, the lifestyle and environmental levers that actually reverse chronic conditions, and how AI, continuous data, and systems biology could finally shift medicine from sick-care to true health-care.
Sponsors: USE CODE “siliconfox20” for 20% off your first SiPhox Health test → siphoxhealth.com/programs
Give your brain and body smarter fuel with Kenetik — a clean, ready-to-drink ketone shot for energy, focus, and endurance. Get 20% off using code "KCP-Ketones" → drinkkenetik.com/discount/KCPBiological Age Data: Genetics, methylation, and cutting edge research with Dr. Adiv JohnsonThe Silicon Fox Podcast with Mitchell Leshchiner2025-11-14 | In this episode of The Silicon Fox Podcast, we sit down with Dr. Adiv Johnson, a leading researcher at the frontier of biological age, genetics, and methylation science.
We break down what your biological age actually measures, how methylation clocks work under the hood, and what current science gets right, and wrong, about predicting longevity. Dr. Johnson unpacks the cutting-edge research behind aging biomarkers, why genetics only tells part of the story, and how lifestyle, environment, and molecular signatures shape the rate at which we age.
We also dive into the future of personalized health: real-time biological age tracking, interventions that actually move the needle, and what the next decade of longevity science will look like as measurement evolves from lab snapshots to continuous molecular monitoring.
Sponsors: USE CODE “siliconfox20” for 20% off your first SiPhox Health test → siphoxhealth.com/programs
Give your brain and body smarter fuel with Kenetik — a clean, ready-to-drink ketone shot for energy, focus, and endurance. Get 20% off using code "KCP-Ketones" → drinkkenetik.com/discount/KCPCulture In Healthcare Startups with Jim DonnellyThe Silicon Fox Podcast with Mitchell Leshchiner2025-11-06 | In this episode of The Silicon Fox Podcast, we sit down with Jim Donnelly, founder of HumanHut and a pioneer at the intersection of culture, wellness, and entrepreneurship.
We explore how great health companies are built from the inside out—why culture isn’t just a “nice to have,” but the true operating system behind behavior change and lasting impact. Jim breaks down how physical wellness experiences are evolving, what most founders get wrong about human connection in healthcare, and how to build environments that make people feel better before they ever buy anything.
We also dive into the new economics of wellness, how space and psychology intertwine, and what it really takes to scale science-backed health experiences without losing soul or authenticity.
Sponsors: USE CODE “siliconfox20” for 20% off your first SiPhox Health test → siphoxhealth.com/programs
Give your brain and body smarter fuel with Kenetik — a clean, ready-to-drink ketone shot for energy, focus, and endurance. Get 20% off using code "KCP-Ketones" → drinkkenetik.com/discount/KCP-KetonesSleep is not a one size fits all #podcast #sleep #health #wellnessThe Silicon Fox Podcast with Mitchell Leshchiner2025-11-05 | ...Straws that reduce sleep apnea #podcast #sleep #jawline #healthThe Silicon Fox Podcast with Mitchell Leshchiner2025-11-05 | ...Biomarker Breakdown: CreatinineThe Silicon Fox Podcast with Mitchell Leshchiner2025-10-30 | In this episode of The Silicon Fox Podcast, we break down creatinine, one of the key biomarkers used to measure kidney function, hydration status, and recovery efficiency. Learn how this simple molecule produced as a byproduct of muscle metabolism reveals deep insights into your body’s filtration capacity, electrolyte balance, and overall metabolic stress.
We explore how creatinine levels change with training intensity, dehydration, protein intake, and sleep, and why tracking these trends can help you prevent overtraining, optimize recovery, and protect long-term health. You’ll also learn the difference between creatinine and creatine, how to interpret your results, and practical ways to maintain optimal levels through nutrition, hydration, and performance strategies.
USE CODE: siliconfox20 for 20% off your first order — siphoxhealth.com/programsInvest in your sleep w/ Grayson JudgeThe Silicon Fox Podcast with Mitchell Leshchiner2025-10-24 | In this episode of The Silicon Fox Podcast, we sit down with Grayson Judge, co-founder of Supermoon, to unpack how sleep is becoming the next great frontier of human performance, health, and longevity.
We explore the most misunderstood truths about sleep, the biological levers that actually move the needle beyond melatonin and magnesium, and why the 8-hour rule might soon look like a relic of the past.
Grayson shares his perspective on the missing infrastructure between sleep data and behavior change, what it takes to build inevitable health companies, and why the future of recovery might replace medication for chronic disease.
We also dive into the coming era of programmable sleep, from lucid-dreaming APIs to AI-driven optimization, and how sleep could redefine both personal performance and population health over the next decade.
USE CODE: “siliconfox20” for 20% off your first SiPhox Health test → siphoxhealth.com/programsAIs impact on human value #ai #health #wellness #writingThe Silicon Fox Podcast with Mitchell Leshchiner2025-10-22 | ...Will AI create durable companies in healthcare today? #podcast #startup #fitness #aiThe Silicon Fox Podcast with Mitchell Leshchiner2025-10-16 | ...Longevity Festivals & Building Communities through Health with Sean HoessThe Silicon Fox Podcast with Mitchell Leshchiner2025-10-16 | In this episode of The Silicon Fox Podcast, we sit down with Sean Hoess, co-founder of the Eudēmonia Summit and long-time architect of global wellness communities, to unpack how connection itself is becoming the new biomarker for health.
We explore the how and why behind building communities that truly move people, from the psychology of belonging to the design principles that turn ideas into thriving ecosystems.
Sean shares what he’s learned from years of cultivating purpose-driven gatherings around wellness, music, and human performance, and how the next evolution of community will merge health, technology, and meaning in unexpected ways.
We also look ahead at the future of collective wellbeing: what the data says about social connection and longevity, why “health through community” might outperform any supplement or wearable, and how founders and creators can build movements that outlive their own momentum.
USE CODE: “siliconfox20” for 20% off your first SiPhox Health test → siphoxhealth.com/programsWellness vs Clinical Health #podcast #health #fitness #startupThe Silicon Fox Podcast with Mitchell Leshchiner2025-10-15 | ...Inside the $4.5 Trillion Problem: Investing, Longevity, and the Future of Healthtech with Eric BerryThe Silicon Fox Podcast with Mitchell Leshchiner2025-10-09 | In this episode of The Silicon Fox Podcast, we sit down with Eric Berry, investor and partner at Averin, to decode how top venture minds are rethinking healthcare from the ground up.
We dive deep into how to underwrite timing risk in healthcare, what founders consistently get wrong about system incentives, and the common DNA across companies that truly scale in this $4.5T industry.
Eric shares his perspective on vertical vs horizontal AI, the real definition of value-based care, and how data becomes powerful enough to transform from a feature into a full company.
We also explore the frontier of longevity and early detection, what makes a company fundable in aging, and the coming collision of payers vs. providers as AI and precision medicine reshape incentives.
USE CODE: “siliconfox20” for 20% off your first SiPhox Health test → siphoxhealth.com/programsHealth Habit: Protein IntakeThe Silicon Fox Podcast with Mitchell Leshchiner2025-09-25 | In this episode, we break down protein intake not just as a muscle-building macronutrient, but as a foundational lever for metabolism, longevity, and daily energy.
You’ll learn:
💪 Why protein isn’t just for athletes — but crucial for aging, recovery, and blood sugar control
🍗 How much protein you actually need per day based on your goals (hint: it’s probably more than you think)
⏱️ The best timing, distribution, and types of protein to support muscle protein synthesis and fat loss
⚖️ The risks of too little protein — especially as we age
🥩 Debunking common myths about protein and kidney damage, longevity tradeoffs, and plant vs animal sources
In this episode, we dive into melatonin, not just as a sleep aid, but as a master regulator of circadian rhythm, hormone signaling, and cellular repair.
You’ll learn:
🧬 Why melatonin is one of the body’s most powerful antioxidants, and not just for sleep
⏰ How light exposure, meal timing, and habits block or boost natural melatonin production
💊 Whether supplementing with melatonin helps or hurts your long-term health
🚫 The dark side of over-the-counter melatonin: dosage mismatches, hormonal disruption, and dependency
🌙 Sleep hacks rooted in biology, not just products
We also explore emerging science on melatonin’s roles in immunity, anti-aging, and metabolic health, and what habits actually enhance your body’s ability to produce it naturally.
👉 USE CODE: siliconfox20 for 20% OFF your first SiPhox Health order: siphoxhealth.com/programsBiomarker Breakdown: Testosterone-to-Cortisol RatioThe Silicon Fox Podcast with Mitchell Leshchiner2025-09-12 | In this episode of The Silicon Fox Podcast, we break down the testosterone-to-cortisol (T:C) ratio, one of the most powerful biomarkers for understanding stress, recovery, and performance. Discover how the balance between these two hormones influences muscle growth, metabolism, mood, resilience, and long-term health. We also cover how to track and optimize your T:C ratio with evidence-based strategies for training, recovery, and lifestyle.